Association between sleep-related phenotypes and gut microbiota: a two-sample bidirectional Mendelian randomization study

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 2, 2024

Background An increasing body of evidence suggests a profound interrelation between the microbiome and sleep-related concerns. Nevertheless, current observational studies can merely establish their correlation, leaving causality unexplored. Study objectives To ascertain whether specific gut microbiota are causally linked to seven characteristics propose potential strategies for insomnia prevention. Methods The study employed an extensive dataset genetic variations from MiBioGen alliance, encompassing 18,340 individuals. Taxonomic classification was conducted, identifying 131 genera 196 bacterial taxa analysis. Sleep-related phenotype (SRP) data were sourced IEU OpenGWAS project, covering traits such as insomnia, chronotype, snoring. Instrumental variables (IVs) selected based on criteria, including locus-wide significance, linkage disequilibrium calculations, allele frequency thresholds. Statistical methods explore causal relationships, inverse variance weighted (IVW), MR-Egger, median, Mode. Sensitivity analyses, pleiotropy assessments, Bonferroni corrections ensured result validity. Reverse analysis adherence STROBE-MR guidelines conducted bolster study’s rigor. Results Bidirectional Mendelian randomization (MR) reveals causative interplay phenotypes. Notably, outcomes rigorously Bonferroni-corrected examination illuminate correlations amid precise compositions intestinal slumber-associated parameters. Elevated abundance within taxonomic ranks class Negativicutes order Selenomonadales markedly associated with heightened susceptibility severe (OR = 1.03, 95% CI: 1.02–1.05, p 0.0001). Conversely, augmented representation phylum Lentisphaerae stands in concord protracted sleep duration 1.02, 1.01–1.04, 0.0005). Furthermore, exposure genus Senegalimassilia exhibits ameliorate manifestation snoring symptoms 0.98, 0.96–0.99, Conclusion This has unveiled relationship SRPs, bestowing significant latent value upon future endeavors both foundational research clinical therapy.

Language: Английский

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Current Status of Research on the Treatment of Insomnia with Acupuncture

Journal of Contemporary Medical Practice, Journal Year: 2024, Volume and Issue: 6(6), P. 192 - 200

Published: June 30, 2024

Insomnia is a non-organic sleep disorder that currently affects the quality of life people around globe, and has received widespread attention at home abroad. Current treatments such as psychotherapy, medication, physical therapy can improve patients' quality, but they have drawbacks high price, drug resistance, easy to damage skin, whereas acupuncture significant efficacy, few side effects, low ease use in treatment insomnia. Acupuncture widely recognised insomnia, research on different therapies increasing year by year. By searching Chinese Journal Full Text Database (CNKI), Wanfang PubMed Database, relevant clinical randomised controlled trials for insomnia past 6 years were included generalisation summary, aiming provide clinicians with new ideas methods

Language: Английский

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Smartphone application‐delivered cognitive behavioural therapy for insomnia with telephone support for insomnia disorder compared to a waitlist control: a randomised clinical trial

Journal of Sleep Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Summary Although there have been promising findings for smartphone application (app)‐delivered cognitive behavioural therapy insomnia (CBT‐I), previous trials not screened participants rigorously disorder and used therapist support. Based on the above, we aimed to examine effects of app‐delivered CBT‐I with telephone support against a waitlist (WL) in sample disorder. A total 64 were randomised ( n = 32) or WL 32). Smartphone consisted six weekly app modules 15 min per week. At pre‐ post‐treatment, 3‐month follow‐up, assessed symptoms associated correlates consequences. also measures related adherence (therapist support, exercise/module completion), self‐rated perception treatment content, activity, adverse events. significantly outperformed large primary outcome d 2.26) was different most secondary outcomes medium effects. resulted larger proportion remitters (CBT‐I: 64.5–77.4%, WL: 6.5–6.9%) responders 77.4–90.3%, 19.4–24.1%) at post‐treatment compared WL. Treatment high satisfaction, adherence, low attrition, few treatment‐impeding this trial highlights potential delivering exclusively through an efficacy, adherence.

Language: Английский

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