Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 3, 2024
Abstract
Background
Previous
studies
have
reported
an
association
between
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
and
risk
of
severe
bacterial
infections.
However,
the
magnitude
whether
this
varies
with
severity
MASLD
remains
uncertain.
We
performed
a
meta-analysis
observational
to
quantify
infections
requiring
hospital
admission.
Methods
systematically
searched
PubMed,
Scopus,
Web
Science
Embase
from
database
inception
April
1,
2024,
using
predefined
keywords
identify
examining
amongst
individuals
without
MASLD.
was
diagnosed
biopsy,
imaging,
or
International
Classification
Diseases
codes.
Meta-analysis
random-effects
modelling.
Results
identified
six
cross-sectional
two
prospective
aggregate
data
on
~
26.6
million
individuals.
significantly
associated
higher
odds
(pooled
ratio
1.93,
95%CI
1.44–2.58;
I2
=
93%).
showed
that
MAFLD
increased
developing
incident
hazard
1.80,
1.62-2.0;
89%).
This
across
MASLD,
especially
fibrosis
2.42,
1.89–2.29;
92%).
These
results
remained
significant
after
adjusting
for
age,
sex,
obesity,
diabetes,
other
potential
confounders.
Sensitivity
analyses
did
not
modify
these
findings.
The
funnel
plot
reveal
any
publication
bias.
Conclusions
shows
