Association Between MASLD and Increased Risk of Serious Bacterial Infections Requiring Hospital Admission: Its Early Days DOI Open Access
Zeyu Wang, Dong Wan, Mei‐Dong Xu

et al.

Liver International, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 17, 2024

We would like to acknowledge the contribution of meta-analysis conducted by Mantovani et al. [1], which substantiates significant association between dysfunction-associated steatotic liver disease (MASLD) and an elevated risk serious bacterial infections necessitating hospital admission. With shifts in lifestyle dietary patterns, MASLD has emerged as predominant disease, imposing a substantial social economic burden globally [2]. MAFLD extends beyond hepatic implications, exhibiting close associations with cardiovascular, renal, orthopaedic, endocrine oncological systems [3]. The infection remains insufficiently explored existing literature. This article presents rigorous investigation sample size is pioneering performing examine correlation severe infections. By synthesising data from eight studies, encompassing approximately 26 million individuals, study elucidates relationship findings have generated considerable interest warrant further inquiry. Nevertheless, following points require in-depth exploration. Firstly, figure 1, author combined analyses cross-sectional case–control studies within meta-analysis, could introduce potential bias into results. Secondly, incorporated this (references 18–21), notable age disparity exists group non-MASLD group, older patients higher propensity for developing comparison their younger counterparts [4, 5]. Consequently, variability baseline may substantially influence outcomes analysis. Finally, some included analysis contain duplicate patient data, such those 21 22), both derived Swedish Nationwide population-based cohort overlapping follow-up periods (1969 2017 vs. 1987 2020). overlap contradicts principles literature inclusion meta-analyses affect strongly concur author's article. Given that these factors above might results, we enumerate them reference readers. In conclusion, has, first time, elucidated infections, thereby enhancing awareness risks linked among researchers. Nonetheless, large-sample, multi-centre long-term are necessary substantiate findings. Z.W., D.W., M.X., Y.J. contributed preparation paper. read agreed published version manuscript. all authors' hard work. authors declare no conflicts interest. Data sharing not applicable datasets were or analysed during current study.

Language: Английский

Risk of Serious Bacterial and Non‐Bacterial Infections in People With MASLD DOI Creative Commons
Giovanni Targher, Herbert Tilg, Luca Valenti

et al.

Liver International, Journal Year: 2025, Volume and Issue: 45(4)

Published: March 12, 2025

ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become the most common chronic globally. MASLD is a multisystem where metabolic dysfunction plays key role in development of and its relevant liver‐related morbidities extrahepatic complications, such as cardiovascular disease, kidney certain types cancers. Among least examined MASLD‐related an ever‐increasing number observational studies have reported positive association between risk serious bacterial infections (SBI) requiring hospital admission. This remained significant those statistical analysis was adjusted for age, sex, ethnicity, obesity, type 2 diabetes other comorbidities. Notably, incidence rates SBI were further increased with more advanced MASLD, especially patients cirrhosis, also observed some acute viral infections, including SARS‐CoV‐2 infection, leading to severe COVID‐19. In this narrative review article, we provide overview literature on (a) recent epidemiological data linking non‐bacterial admission, (b) putative underlying mechanisms through which may increase susceptibility both directly immune associated cirrhosis portal hypertension, (c) practical clinical implications growing global population MASLD.

Language: Английский

Citations

1
Visceral Fat, Metabolic Health, and Lifestyle Factors in Obstructive Bronchial Diseases: Insights from Bioelectrical Impedance Analysis DOI Open Access
Sanda Mihaela Popescu, Andreea Mihai, Adina Turcu-Știolică

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1024 - 1024

Published: March 14, 2025

Background/Objectives: This study examines the relationship between visceral fat (VF), metabolic health, and dietary patterns in patients with obstructive bronchial diseases (OBDs) using bioelectrical impedance analysis (BIA). Methods: A total of 75 diagnosed OBD, including chronic pulmonary disease (COPD) and/or asthma, were assessed for VF levels via BIA. Dietary habits evaluated a structured questionnaire to explore their correlation accumulation. Results: The cohort comprised predominantly male participants (66.7%), majority aged 61 70 years (46.7%). Significant gender differences distribution observed, 60% females maintaining normal (1–9) compared only 28% males, while 38% males exhibited very high (15–30; p = 0.003). Body mass index (BMI) showed strong (p < 0.0001), as overweight obese individuals displayed elevated (≥10). Moreover, syndrome (MS) was present 66.7% participants, these exhibiting significantly higher those without MS 0.001). revealed that frequent consumption fast food (r 0.717, 0.001), carbonated drinks 0.366, refined carbohydrates 0.438, 0.001) associated increased Conversely, intake water −0.551, fruits −0.581, vegetables −0.482, correlated lower levels. Lack physical activity also strongly linked accumulation 0.481, further reinforcing role lifestyle factors health. Conclusions: findings underscore significant impact on OBD patients. BMI emerged critical predictors VF, unhealthy sedentary lifestyles exacerbated deposition. Elevated adverse lipid profiles, need modifications managing health among Although no direct association identified forced expiratory volume one second (FEV1), results highlight necessity integrated nutritional interventions management respiratory diseases.

Language: Английский

Citations

0
Response Letter: Association Between MASLD and Increased Risk of Serious Bacterial Infections Requiring Hospital Admission: It's Early Days DOI
Alessandro Mantovani, Giovanni Targher

Liver International, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 17, 2024

The authors have nothing to report.

Language: Английский

Citations

0
Association Between MASLD and Increased Risk of Serious Bacterial Infections Requiring Hospital Admission: Its Early Days DOI Open Access
Zeyu Wang, Dong Wan, Mei‐Dong Xu

et al.

Liver International, Journal Year: 2024, Volume and Issue: 45(1)

Published: Dec. 17, 2024

We would like to acknowledge the contribution of meta-analysis conducted by Mantovani et al. [1], which substantiates significant association between dysfunction-associated steatotic liver disease (MASLD) and an elevated risk serious bacterial infections necessitating hospital admission. With shifts in lifestyle dietary patterns, MASLD has emerged as predominant disease, imposing a substantial social economic burden globally [2]. MAFLD extends beyond hepatic implications, exhibiting close associations with cardiovascular, renal, orthopaedic, endocrine oncological systems [3]. The infection remains insufficiently explored existing literature. This article presents rigorous investigation sample size is pioneering performing examine correlation severe infections. By synthesising data from eight studies, encompassing approximately 26 million individuals, study elucidates relationship findings have generated considerable interest warrant further inquiry. Nevertheless, following points require in-depth exploration. Firstly, figure 1, author combined analyses cross-sectional case–control studies within meta-analysis, could introduce potential bias into results. Secondly, incorporated this (references 18–21), notable age disparity exists group non-MASLD group, older patients higher propensity for developing comparison their younger counterparts [4, 5]. Consequently, variability baseline may substantially influence outcomes analysis. Finally, some included analysis contain duplicate patient data, such those 21 22), both derived Swedish Nationwide population-based cohort overlapping follow-up periods (1969 2017 vs. 1987 2020). overlap contradicts principles literature inclusion meta-analyses affect strongly concur author's article. Given that these factors above might results, we enumerate them reference readers. In conclusion, has, first time, elucidated infections, thereby enhancing awareness risks linked among researchers. Nonetheless, large-sample, multi-centre long-term are necessary substantiate findings. Z.W., D.W., M.X., Y.J. contributed preparation paper. read agreed published version manuscript. all authors' hard work. authors declare no conflicts interest. Data sharing not applicable datasets were or analysed during current study.

Language: Английский

Citations

0