Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Feb. 26, 2024
Invasive
fungal
super-infection
(IFSI)
is
an
added
diagnostic
and
therapeutic
dilemma.
We
aimed
to
develop
assess
a
nomogram
of
IFSI
in
patients
with
healthcare-associated
bacterial
infection
(HABI).
An
ambispective
cohort
study
was
conducted
ICU
HABI
from
tertiary
hospital
China.
Predictors
were
selected
by
both
the
least
absolute
shrinkage
selection
operator
(LASSO)
method
two-way
stepwise
method.
The
predictive
performance
two
models
built
logistic
regression
internal-validated
compared.
Then
external
validity
assessed
web-based
deployed.
Between
Jan
1,
2019
June
30,
2023,
12,305
screened
14
ICUs,
whom
372
(3.0%)
developed
IFSI.
Among
strains
causing
IFSI,
most
common
C.albicans
(34.7%)
decreasing
proportion,
followed
C.tropicalis
(30.9%),
A.fumigatus
(13.9%)
C.glabrata
(10.1%)
increasing
proportions
year
year.
Compared
LASSO-model
that
included
five
predictors
(combination
priority
antimicrobials,
immunosuppressant,
MDRO,
aCCI
S.aureus),
discriminability
stepwise-model
improved
6.8%
after
adding
more
COVID-19
microbiological
test
before
antibiotics
use
(P<0.01).And
showed
similar
derivation
(the
area
under
curve,
AUC=0.87)
validation
cohorts
(AUC=0.84,
P=0.46).
No
significant
gaps
existed
between
proportion
actual
diagnosed
frequency
predicted
(P=0.16,
0.30
0.35,
respectively).
incidence
appeared
be
temporal
rising,
our
externally
validated
will
facilitate
development
targeted
timely
prevention
control
measures
based
on
specific
risks
Microbiological Research,
Journal Year:
2023,
Volume and Issue:
280, P. 127592 - 127592
Published: Dec. 27, 2023
Plant
growth-promoting
rhizobacteria,
such
as
Bacillus
spp.,
establish
beneficial
associations
with
plants
and
may
inhibit
the
growth
of
phytopathogenic
fungi.
However,
these
bacteria
are
subject
to
multiple
biotic
stimuli
from
their
competitors,
causing
stress
modifying
development.
This
work
is
a
study
an
in
vitro
interaction
between
two
model
microorganisms
socioeconomic
relevance,
using
population
dynamics
transcriptomic
approaches.
Co-cultures
velezensis
83
fungus
Colletotrichum
gloeosporioides
09
were
performed
evaluate
metabolic
response
under
conditions
non-nutritional
limitation.
The
bacterial
was
associated
induction
stress-resistant
phenotype,
characterized
by
lower
specific
rate,
but
antimicrobial
production
capacity.
About
12%
co-cultured
B.
coding
sequences
differentially
expressed,
including
up-regulation
general
(sigB
regulon),
down-regulation
alternative
carbon
sources
catabolism
(glucose
preference).
Defense
strategies
determining
factor
order
preserve
long-term
viability
its
population.
Mostly,
presence
does
not
affect
expression
antibiosis
genes,
except
for
those
corresponding
surfactin/bacillomycin
D
production.
Indeed,
genes
growth,
regardless
fungus.
behavior
resembles
strategy
used
classical
Greek
phalanx
formation:
sacrificing
rate
versatility,
resources
can
be
redistributed
defense
(stress
resistant
phenotype)
while
maintaining
attack
(antibiosis
capacity).
presented
results
first
characterization
molecular
phenotype
at
transcriptome
level
biological
control
agent
caused
phytopathogen
without
nutrient
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1650 - 1650
Published: Aug. 12, 2024
The
unresolved
challenges
in
the
development
of
highly
efficient,
stable
and
controlled
synthetic
microbial
consortia,
as
well
use
natural
are
very
attractive
for
science
technology.
However,
consortia
management
should
be
done
with
knowledge
how
not
only
to
accelerate
but
also
stop
action
such
"little
pots".
Moreover,
there
a
lot
activity
which
suppressively
controlled.
processes,
catalyzed
by
various
microorganisms
being
complex
slowed
down
or
completely
cancelled,
typical
environment
(biocorrosion,
landfill
gas
accumulation,
biodegradation
building
materials,
water
sources
deterioration
etc.),
industry
(food
biotechnological
production),
medical
practice
(vaginitis,
cystitis,
intestinal
dysbiosis,
etc.).
search
ways
suppress
functioning
heterogeneous
each
these
areas
is
relevant.
purpose
this
review
summarize
general
trends
studies
regarding
targets
new
means
influence
used.
analysis
features
applied
approaches
solving
main
problem
confirms
possibility
obtaining
combined
effect,
selective
on
individual
components
consortia.
Of
particular
interest
role
viruses
suppressing
different
compositions.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Feb. 26, 2024
Invasive
fungal
super-infection
(IFSI)
is
an
added
diagnostic
and
therapeutic
dilemma.
We
aimed
to
develop
assess
a
nomogram
of
IFSI
in
patients
with
healthcare-associated
bacterial
infection
(HABI).
An
ambispective
cohort
study
was
conducted
ICU
HABI
from
tertiary
hospital
China.
Predictors
were
selected
by
both
the
least
absolute
shrinkage
selection
operator
(LASSO)
method
two-way
stepwise
method.
The
predictive
performance
two
models
built
logistic
regression
internal-validated
compared.
Then
external
validity
assessed
web-based
deployed.
Between
Jan
1,
2019
June
30,
2023,
12,305
screened
14
ICUs,
whom
372
(3.0%)
developed
IFSI.
Among
strains
causing
IFSI,
most
common
C.albicans
(34.7%)
decreasing
proportion,
followed
C.tropicalis
(30.9%),
A.fumigatus
(13.9%)
C.glabrata
(10.1%)
increasing
proportions
year
year.
Compared
LASSO-model
that
included
five
predictors
(combination
priority
antimicrobials,
immunosuppressant,
MDRO,
aCCI
S.aureus),
discriminability
stepwise-model
improved
6.8%
after
adding
more
COVID-19
microbiological
test
before
antibiotics
use
(P<0.01).And
showed
similar
derivation
(the
area
under
curve,
AUC=0.87)
validation
cohorts
(AUC=0.84,
P=0.46).
No
significant
gaps
existed
between
proportion
actual
diagnosed
frequency
predicted
(P=0.16,
0.30
0.35,
respectively).
incidence
appeared
be
temporal
rising,
our
externally
validated
will
facilitate
development
targeted
timely
prevention
control
measures
based
on
specific
risks
