The hippo pathway: a molecular bridge between environmental cues and pace of life
BMC Ecology and Evolution,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 24, 2025
Abstract
The
pace
of
life
(POL)
is
shaped
by
a
complex
interplay
between
genetic
and
environmental
factors,
influencing
growth,
maturation,
lifespan
across
species.
Hippo
signaling
pathway,
key
regulator
organ
size
cellular
homeostasis,
has
emerged
as
central
integrator
cues
that
modulate
POL
traits.
In
this
review,
we
explore
how
the
pathway
links
factors—such
temperature
fluctuations
dietary
energy
availability—to
molecular
mechanisms
governing
metabolic
balance,
hormonal
signaling,
reproductive
timing.
Specifically,
highlight
regulatory
interactions
sensors
(AMPK,
mTOR,
SIRT1
DLK1-Notch),
well
signals
(IGF-1,
kisspeptin,
leptin,
cortisol,
thyroid
sex
steroids),
which
together
orchestrate
life-history
traits,
including
growth
rates,
sexual
with
particular
emphasis
on
their
role
in
Furthermore,
consider
its
potential
coordinator
POL-related
processes,
such
telomere
dynamics
epigenetic
mechanisms,
within
broader
network.
By
integrating
insights
from
biology
eco-evolutionary
perspectives,
propose
future
directions
to
dissect
pathway’s
regulation
taxa.
Understanding
these
will
provide
new
perspectives
organisms
adaptively
adjust
strategies
response
variability.
Language: Английский
Genetic and telomeric variability: Insights from a tropical avian hybrid zone
Molecular Ecology,
Journal Year:
2024,
Volume and Issue:
33(18)
Published: Aug. 27, 2024
Abstract
Telomere
lengths
and
telomere
dynamics
can
correlate
with
lifespan,
behaviour
individual
quality.
Such
relationships
have
spurred
interest
in
understanding
variation
their
within
between
populations.
Many
studies
identified
how
environmental
processes
influence
dynamics,
but
the
role
of
genetic
is
much
less
well
characterized.
To
provide
a
novel
perspective
on
telomeric
relates
to
variability,
we
longitudinally
sampled
individuals
across
narrow
hybrid
zone
(
n
=
127
samples),
wherein
two
Manacus
species
characterized
by
contrasting
genome‐wide
heterozygosity
interbreed.
We
measured
66)
population
3)
differences
and,
among
hybrids,
amount
admixture
using
RADseq‐generated
SNPs.
tested
for
dynamics.
then
examined
covaried
Hybrid
exhibited
longer
telomeres,
average,
than
adjacent
parental
No
were
observed.
Within
relatively
low
heterozygosity,
higher
was
associated
shorter
telomeres
rates
shortening—a
pattern
that
apparent
other
All
these
independent
sex,
despite
life
histories
male
female
manakins.
Our
study
highlights
comparisons
reveal
interrelationships
naturally
occurring
hybridization
relate
Language: Английский
Early‐life telomere length predicts life‐history strategy and reproductive senescence in a threatened wild songbird
Molecular Ecology,
Journal Year:
2023,
Volume and Issue:
32(14), P. 4031 - 4043
Published: May 12, 2023
Abstract
Telomeres
are
well
known
for
their
associations
with
lifespan
and
ageing
across
diverse
taxa.
Early‐life
telomere
length
can
be
influenced
by
developmental
conditions
has
been
shown
positively
affect
lifetime
reproductive
success
in
a
limited
number
of
studies.
Whether
these
effects
caused
change
lifespan,
rate
or
perhaps
most
importantly
senescence
is
unclear.
Using
long‐term
data
on
female
breeding
from
threatened
songbird
(the
hihi,
Notiomystis
cincta
),
we
show
that
the
early‐life
individuals
predicts
presence
future
key
traits:
clutch
size
hatching
success.
In
contrast,
fledging
not
associated
length,
which
may
due
to
added
influence
biparental
care
at
this
stage.
does
predict
species.
Females
therefore
allocation
strategy
depending
early
conditions,
hypothesise
reflected
length.
Our
results
offer
new
insights
role
telomeres
play
individual
fitness
suggest
used
as
predictor
life
history
Language: Английский