The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards DOI Creative Commons
Mats Olsson, Emily Miller, Nicky Rollings

et al.

Evolution, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten their main repair system in ectotherms - telomerase – replaces lost nucleotide complexes ((T2AG3)n vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance its effects on lifespan-reproductive tradeoffs the wild. In sand lizards (Lacerta agilis), we show higher female investments into reproduction results corresponding shortening males have less frequent profound than females; contributing factor this may be males’ levels. To manipulate access maintenance, exploit pseudo-experimental opportunity analyze ‘onboard’ resources long-term using drop tails with fat nutrient deposits when attacked by predators. Females due regrown often profoundly elongate telomeres. Adult most TL elongation live longest, females highest lifetime reproductive success most, whereas success. This suggests ongoing evolution resource-constrained maintenance.

Language: Английский

Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quail DOI Creative Commons
Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus

et al.

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(8)

Published: April 2, 2024

Resources are needed for growth, reproduction and survival, organisms must trade off limited resources among competing processes. Nutritional availability in is sensed monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form adaptive plasticity when individuals encounter constraints their energy budget. Despite fundamental importance this process evolutionary biology, how nutritional limitation regulated through expression genes governing pathway its consequential effects on fitness remain understudied, particularly birds. We used dietary restriction to simulate resource depletion examined body mass, Japanese quails (Coturnix japonica). Quails were subjected feeding at 20%, 30% 40% levels ad libitum 2 weeks. All restricted groups exhibited reduced whereas reductions number mass eggs observed only under more severe restrictions. Additionally, led decreased mTOR insulin-like growth factor 1 (IGF1), ribosomal protein S6 kinase (RPS6K1) autophagy-related (ATG9A ATG5) upregulated. The pattern which responded was similar mass. Regardless treatment, proportionally higher reproductive investment associated with individual variation These findings reveal connection between intake related pathway.

Language: Английский

Citations

4
The hippo pathway: a molecular bridge between environmental cues and pace of life DOI Creative Commons
Ehsan Pashay Ahi,

Bineet Panda,

Craig R. Primmer

et al.

BMC Ecology and Evolution, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Abstract The pace of life (POL) is shaped by a complex interplay between genetic and environmental factors, influencing growth, maturation, lifespan across species. Hippo signaling pathway, key regulator organ size cellular homeostasis, has emerged as central integrator cues that modulate POL traits. In this review, we explore how the pathway links factors—such temperature fluctuations dietary energy availability—to molecular mechanisms governing metabolic balance, hormonal signaling, reproductive timing. Specifically, highlight regulatory interactions sensors (AMPK, mTOR, SIRT1 DLK1-Notch), well signals (IGF-1, kisspeptin, leptin, cortisol, thyroid sex steroids), which together orchestrate life-history traits, including growth rates, sexual with particular emphasis on their role in Furthermore, consider its potential coordinator POL-related processes, such telomere dynamics epigenetic mechanisms, within broader network. By integrating insights from biology eco-evolutionary perspectives, propose future directions to dissect pathway’s regulation taxa. Understanding these will provide new perspectives organisms adaptively adjust strategies response variability.

Language: Английский

Citations

0
The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards DOI Creative Commons
Mats Olsson, Emily Miller, Nicky Rollings

et al.

Evolution, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten their main repair system in ectotherms - telomerase – replaces lost nucleotide complexes ((T2AG3)n vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance its effects on lifespan-reproductive tradeoffs the wild. In sand lizards (Lacerta agilis), we show higher female investments into reproduction results corresponding shortening males have less frequent profound than females; contributing factor this may be males’ levels. To manipulate access maintenance, exploit pseudo-experimental opportunity analyze ‘onboard’ resources long-term using drop tails with fat nutrient deposits when attacked by predators. Females due regrown often profoundly elongate telomeres. Adult most TL elongation live longest, females highest lifetime reproductive success most, whereas success. This suggests ongoing evolution resource-constrained maintenance.

Language: Английский

Citations

0