Galactose‐α‐1,3‐galactose‐presenting bacterial families are associated with resistance to experimental avian malaria infection DOI Creative Commons
Robert Noble, T. R. KELLY, Christine R. Lattin

et al.

Journal of Avian Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

The gut microbiome can contribute to host health through defense against pathogens. However, links between the and resistance infection have been primarily investigated in humans lab‐bred rodents, so we do not know what extent this relationship exists wild animals. To fill knowledge gap, used an experimental malaria inoculation with Plasmodium relictum wild‐caught house sparrows Passer domesticus (n = 18) examine interactions of avian infection. Before after inoculation, collected blood samples quantify circulating parasitemia fecal evaluate amplification sequencing V4 region bacterial 16S rRNA gene. We found that alpha diversity (species richness evenness) beta (community composition) were significantly different infected resistant prior or during identified several indicator ASVs occurred at higher prevalence proportional abundance malaria‐resistant sparrows, most which from family Lactobacillaceae is hypothesized confer inducing production anti‐α‐Gal antibodies. Future studies should experimentally manipulate composition causally investigate specific taxa

Language: Английский

Galactose‐α‐1,3‐galactose‐presenting bacterial families are associated with resistance to experimental avian malaria infection DOI Creative Commons
Robert Noble, T. R. KELLY, Christine R. Lattin

et al.

Journal of Avian Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

The gut microbiome can contribute to host health through defense against pathogens. However, links between the and resistance infection have been primarily investigated in humans lab‐bred rodents, so we do not know what extent this relationship exists wild animals. To fill knowledge gap, used an experimental malaria inoculation with Plasmodium relictum wild‐caught house sparrows Passer domesticus (n = 18) examine interactions of avian infection. Before after inoculation, collected blood samples quantify circulating parasitemia fecal evaluate amplification sequencing V4 region bacterial 16S rRNA gene. We found that alpha diversity (species richness evenness) beta (community composition) were significantly different infected resistant prior or during identified several indicator ASVs occurred at higher prevalence proportional abundance malaria‐resistant sparrows, most which from family Lactobacillaceae is hypothesized confer inducing production anti‐α‐Gal antibodies. Future studies should experimentally manipulate composition causally investigate specific taxa

Language: Английский

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