Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Feb. 27, 2025

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Creative Commons
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: April 7, 2025

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0
Olfactory projection neuron rewiring in the brain of an ecological specialist DOI Creative Commons

Benedikt R Dürr,

Enrico Bertolini, S. Takagi

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115615 - 115615

Published: April 25, 2025

Language: Английский

Citations

0
Olfactory projection neuron rewiring in the brain of an ecological specialist DOI Creative Commons

Benedikt R. Duerr,

Enrico Bertolini, S. Takagi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Animals′ behaviours can vary greatly between even closely-related species. While changes in the sensory periphery have frequently been linked to species-specific behaviours, very little is known about if and how individual cell types central brain evolve. Here, we develop a set of advanced genetic tools compare homologous neurons Drosophila sechellia – which specialises on single fruit melanogaster . Through systematic morphological analysis olfactory projection (PNs), reveal that global anatomy these second-order conserved. However, high-resolution, quantitative comparisons identify striking case convergent rewiring PNs two distinct pathways critical for D. ′s host location. Calcium imaging labelling pre-synaptic sites evolved demonstrate novel functional connections with third-order partners are formed This work demonstrates peripheral evolution accompanied by highly-selective wiring facilitate ecological specialisation, paves way comparison other throughout nervous system.

Language: Английский

Citations

2
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic preoptic area (POA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas POA for males females both species. We identify four cell types differentially abundant species, which may account based on functions these types. Our data further implicate sex-biased be important sex-specific behavior. Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

2
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Creative Commons
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice (Peromyscus maniculatus and P. polionotus) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both Peromyscus species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression polionotus, monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

1
Timing-dependent effects of elevated maternal glucocorticoids on offspring brain gene expression in a wild small mammal DOI Creative Commons
Sarah E. Westrick, Eva K. Fischer, Freya van Kesteren

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Abstract An increase in maternal stress during offspring development can have cascading, life-long impacts on behavior and physiology, which vary depending the timing of exposure to stressor. By responding stressors through increasing production glucocorticoids (GCs), hypothalamic-pituitary-adrenal (HPA) axis is a key mediator effects – both side mother offspring. At molecular level, are thought be mediated modifying transcription genes, particularly brain. To better understand evolutionary implications effects, more studies needed mechanisms wild populations. test how gene expression brains offspring, we treated free-ranging North American red squirrels ( Tamiasciurus hudsonicus ) with GCs late pregnancy or early lactation collected from around weaning. We used RNA-sequencing measure hypothalamus hippocampus. found small differences between GC-treated control individuals suggesting long-term GC treatment neural transcription. The general patterns regulation across transcriptome were consistent lactation-treated individuals. However, number significantly differentially expressed genes was higher group. These results support idea that affects these dependent timing. Our findings add valuable insight into impact hormones transcriptomics population.

Language: Английский

Citations

0
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice DOI Open Access
Jenny Chen, P. R. K. Richardson, Christopher Kirby

et al.

Published: Nov. 18, 2024

Genetic variation is known to contribute the of animal social behavior, but molecular mechanisms that lead behavioral differences are still not fully understood. Here, we investigate cellular evolution hypothalamic medial preoptic area (MPOA), a brain region plays critical role in across two sister species deer mice ( Peromyscus maniculatus and P. polionotus ) with divergent systems. These exhibit large mating parental care behavior sex. Using single-nucleus RNA-sequencing, build atlas MPOA for males females both species. We identify four cell types differentially abundant species, which may account behavior. Our data further implicate sex-biased be important sex-specific Finally, show remarkable reduction gene expression , monogamous also exhibits reduced sexual dimorphism powerful resource how neuronal traits evolving give rise innate

Language: Английский

Citations

0