Fish Evo‐Devo: Moving Toward Species‐Specific and Knowledge‐Based Interactome

Journal of Experimental Zoology Part B Molecular and Developmental Evolution, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

ABSTRACT A knowledge‐based interactome maps interactions among proteins and molecules within a cell using experimental data, computational predictions, literature mining. These interactomes are vital for understanding cellular functions, pathways, the evolutionary conservation of protein interactions. They reveal how regulate growth, differentiation, development. Transitioning to functionally validated is crucial in developmental biology (Evo‐Devo), especially non‐model species, uncover unique regulatory networks, novelties, reliable gene interaction models. This enhances our complex trait evolution across species. The European Evo‐Devo 2024 conference Helsinki hosted first fish‐specific symposium, highlighting growing interest fish Advances genome annotation, editing, imaging, molecular screening expanding research. High‐throughput data have enabled deduction networks. next steps involve creating species‐specific interactomes, validating them functionally, integrating additional deepen Evo‐Devo. short review aims address logical this transition, as well necessities limitations journey.

Language: Английский

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Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Abstract Background Sexual maturation in Atlantic salmon entails a transition energy utilization, regulated by genes and environmental stimuli sex-specific manner. Males require less energy, the form of adiposity, to mature typically younger than females. Maturation age is also influenced sex-dependent fashion vgll3 genotype ( vestigial-like 3 ), co-factor Hippo pathway. The underlying molecular processes age, their interplay with adiposity genotypes, remain unclear. Methods To elucidate mechanisms sex- genotype-specific differences, we investigated association early (E) late (L) alleles transcription > 330 involved regulation pathway sexual maturation, related signals brain, adipose, gonads. Results strongest effect was observed adipose for females brain males, highlighting expression differences genotype. Genes ovarian development showed increased vgll3*EE compared vgll3*LL Moreover, males exhibited reduced markers pre-adipocyte differentiation lipolysis yet enhanced adipocyte lipid storage. Brain gene further hormones lipids, as well tight junction assembly. Conclusions Overall, these patterns point towards greater storage slower utilization males. These results suggest Hippo-dependent may be important mediators sex salmon.

Language: Английский

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The hippo pathway: a molecular bridge between environmental cues and pace of life

BMC Ecology and Evolution, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Abstract The pace of life (POL) is shaped by a complex interplay between genetic and environmental factors, influencing growth, maturation, lifespan across species. Hippo signaling pathway, key regulator organ size cellular homeostasis, has emerged as central integrator cues that modulate POL traits. In this review, we explore how the pathway links factors—such temperature fluctuations dietary energy availability—to molecular mechanisms governing metabolic balance, hormonal signaling, reproductive timing. Specifically, highlight regulatory interactions sensors (AMPK, mTOR, SIRT1 DLK1-Notch), well signals (IGF-1, kisspeptin, leptin, cortisol, thyroid sex steroids), which together orchestrate life-history traits, including growth rates, sexual with particular emphasis on their role in Furthermore, consider its potential coordinator POL-related processes, such telomere dynamics epigenetic mechanisms, within broader network. By integrating insights from biology eco-evolutionary perspectives, propose future directions to dissect pathway’s regulation taxa. Understanding these will provide new perspectives organisms adaptively adjust strategies response variability.

Language: Английский

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Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review

Calcified Tissue International, Journal Year: 2025, Volume and Issue: 116(1)

Published: April 3, 2025

Language: Английский

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