Transcriptome analysis reveals modulations in glycosylation profiles of the mucosal barrier and their potential interaction with gut microbiota in weaned piglets DOI Creative Commons
Hao Cheng, Hao Li, Yujie Zhao

et al.

Animal nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The current study aims to investigate the potential interaction between glycosylation profiles of Ningxiang breed (NX) and Western Duroc × Landrace Yorkshire (DLY) weaned piglets, their characteristic microbes, employing integrated analyses transcriptomics metagenomics. Twenty-four (12 NX 12 DLY) at 28 days age were transported into an experimental house fed same piglet diet. trail period was 7 days. Results revealed that piglets had a higher growth-to-feed ratio, body weight gain scale, lower pathological score intestinal injury compared with DLY (P < 0.01). displayed elevated mRNA expression levels MUC2 MUC5AC in colonic mucosal tissue than 0.05). Within O-linked glycosylated differentially expressed genes (DEGs), FNTA, GALNT18, POMGNT1, POMGNT2, POMT1 significantly upregulated relative Conversely, C1GALT2, GALNT1, KMT2C, OGT downregulated KMT2C gene hardly transcriptome piglets. At phylum taxonomic level, abundance Firmicutes, while Proteobacteria. genus Lactobacillus, whereas Collinsella, Enterococcus Escherichia. results correlation differential bacteria O-chain DEG showed GALNT1 KMT2 associated Lactobacillus_pontis positive (R = 0.67). Through comparative analysis functions, this highlights role reduced genes, involved protein glycan reactions, impairing barrier function Furthermore, members Lactobacillus Prevotella genera may actively contribute regulation colon profiles.

Language: Английский

Molecular Microbiology of Microbiomes DOI
Pierre Santucci

Molecular Microbiology, Journal Year: 2024, Volume and Issue: 122(3), P. 271 - 272

Published: Sept. 1, 2024

Language: Английский

Citations

0
Carbohydrate Research Mini-review Relationships between bacteria and the mucus layer DOI
Inka Brockhausen,

Dylan Falconer,

Sara Sara

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 546, P. 109309 - 109309

Published: Nov. 10, 2024

Language: Английский

Citations

0
Transcriptome analysis reveals modulations in glycosylation profiles of the mucosal barrier and their potential interaction with gut microbiota in weaned piglets DOI Creative Commons
Hao Cheng, Hao Li, Yujie Zhao

et al.

Animal nutrition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The current study aims to investigate the potential interaction between glycosylation profiles of Ningxiang breed (NX) and Western Duroc × Landrace Yorkshire (DLY) weaned piglets, their characteristic microbes, employing integrated analyses transcriptomics metagenomics. Twenty-four (12 NX 12 DLY) at 28 days age were transported into an experimental house fed same piglet diet. trail period was 7 days. Results revealed that piglets had a higher growth-to-feed ratio, body weight gain scale, lower pathological score intestinal injury compared with DLY (P < 0.01). displayed elevated mRNA expression levels MUC2 MUC5AC in colonic mucosal tissue than 0.05). Within O-linked glycosylated differentially expressed genes (DEGs), FNTA, GALNT18, POMGNT1, POMGNT2, POMT1 significantly upregulated relative Conversely, C1GALT2, GALNT1, KMT2C, OGT downregulated KMT2C gene hardly transcriptome piglets. At phylum taxonomic level, abundance Firmicutes, while Proteobacteria. genus Lactobacillus, whereas Collinsella, Enterococcus Escherichia. results correlation differential bacteria O-chain DEG showed GALNT1 KMT2 associated Lactobacillus_pontis positive (R = 0.67). Through comparative analysis functions, this highlights role reduced genes, involved protein glycan reactions, impairing barrier function Furthermore, members Lactobacillus Prevotella genera may actively contribute regulation colon profiles.

Language: Английский

Citations

0