Long COVID-19–related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

To compare the magnetic resonance imaging (MRI) features of olfactory cleft (OC) and bulbs (OBs) in patients with long COVID-19-related (LCOD) non-COVID-19 postviral dysfunction (NCPVOD) to explore mechanisms underlying persistent dysfunction. This retrospective analysis included diagnosed LCOD or NCPVOD at China-Japan Friendship Hospital between February 2023 July 2024. All underwent psychophysical testing (Sniffin' Sticks), a visual analogue scale (VAS) for function, high-resolution MRI scans pathway. features, including OC opacity, OB morphology, volume, sulcus depth, were compared groups. Correlations findings test scores assessed. Seventy (35 LCOD, 35 NCPVOD). had significantly higher opacity than (p < 0.001). No significant differences found abnormal signals, volume reduction, distances OBs surrounding structures > 0.05). greater right depth = 0.026), negative correlation age (r -0.25, p 0.04). volumes positively correlated TDI VAS scores. exhibited patients, suggesting inflammation may contribute Treating could improve long-term outcomes. reduction was common both

Language: Английский

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Platelet‐Rich Plasma for Treating COVID‐19‐Related Anosmia, Hyposmia, and Parosmia: A Controlled Longitudinal Study

Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

To investigate the effectiveness of platelet-rich plasma (PRP) injection into olfactory clefts coronavirus disease 2019 (COVID-19) patients with persistent anosmia, hyposmia, and parosmia. Controlled study. Multicenter From March 2022 to July 2024, 514 COVID-19 undergoing PRP training versus (controls) for a dysfunction (OD) were consecutively recruited from two medical centers. Subjects evaluated pre- 3 months post-injection disorder questionnaire (ODQ) threshold, discrimination, identification (TDI) test. Olfactory outcomes compared between controls considering type OD (anosmia, parosmia). The group was composed 416 anosmia (N = 111; 26.7%), hyposmia 160; 38.5%), parosmia 145; 34.9%). baseline ODQ significantly higher than those other groups (P .001). increase in TDI subscores total score all subgroups 0.001). reduced post-PRP Patients showed greater reduction scores control group. 3-month negatively influenced by age (rs -0.263; P 0.001) duration -0.213; experienced stronger impact on quality life (QoL), QoL improvement following injections groups.

Language: Английский

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Advances in the study of mechanisms underlying olfactory dysfunction in obstructive sleep apnea:a narrative review

Sleep and Biological Rhythms, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

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Olfactory receptors and human diseases

Cell and Tissue Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Language: Английский

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Unraveling Dysgeusia in SARS-CoV-2 Infection: Clinical and Laboratory Insights from Hospitalized COVID-19 Patients in Romania

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 300 - 300

Published: March 21, 2025

Introduction: Dysgeusia has been regarded as a clinical feature associated with SARS-CoV-2 infection since the onset of pandemic. The initial circulating variants were linked to presence dysgeusia; however, emergence Omicron variant, incidence dysgeusia decreased. aim this study was identify and characteristics patients from pandemic variant. Methods: We conducted retrospective March 2020 December 2021, among adult hospitalized COVID-19 in main infectious diseases hospital Romania. Clinical laboratory data collected interpreted relation or absence dysgeusia. Results: 32.0%, majority cases (44.2%) occurring Beta predominantly observed mild moderate disease. obesity hypertension shown be negatively development (OR = 0.45, OR 0.39, respectively). In dysgeusia, inflammatory changes such lymphopenia significantly less frequently identified 0.22, p < 0.001), increased C-reactive protein 0.12, 0.001) interleukin-1 0.42, 0.002), fibrinogen 0.31, ferritin 0.27, compared without acute respiratory failure higher group (71.2% vs. 28.8%, 0.001). This accompanied by milder management median duration hospitalization that two days shorter. Conclusions: appears correlate both response outcome. context evolving viral variants, which seem lower continuous monitoring who develop disorder remains essential clarify pathophysiologic mechanisms involved assess potential predictor course infection.

Language: Английский

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Neurological Post-Acute Sequelae of COVID-19 in Non-Hospitalized Patients: An Integrative Review

Biological Research For Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

The COVID-19 pandemic has had a significant impact on the global population. infection, caused by SARS-CoV-2, presents with variety of clinical manifestations, from asymptomatic cases to more severe forms, including neurological symptoms, such as fatigue, weakness, brain fog, paresthesias, dysautonomia, anosmia, and dysgeusia. Additionally, disease is associated long COVID syndrome, in which there persistence effects symptoms acute phase. In recent years literature shown relevant data COVID, but still need deepen knowledge about these term manifestations. Thus, present study aimed describe main sequelae resulting SARS-CoV-2 infection non-hospitalized population during phase disease, gathering scientific evidence through an integrative review prevalence patient profile, duration severity sequelae, risk factors, comorbidities, possible nervous system structural damage. PubMed/Medline database was used descriptors and, at end screening process predefined inclusion exclusion criteria, 22 studies were included. A group identified: myalgia, dysgeusia, memory alterations, olfactory dysfunction, dizziness, pain. Most patients presented multiple that lasted for than one year quality life. factors dyslipidemia, age, ethnicity, muscle/ joint pain, sex. This highlights importance further its etiology, diagnosis, follow-up, treatments.

Language: Английский

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A Randomized Controlled Trial of Anodal transcranial Direct Current Stimulation (A-tDCS) and Olfactory Training in persistent COVID-19 anosmia.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Inflammation and olfactory loss are associated with at least 139 medical conditions

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Oct. 11, 2024

Olfactory loss accompanies at least 139 neurological, somatic, and congenital/hereditary conditions. This observation leads to the question of whether these associations are correlations or they ever causal. Temporal precedence prospective predictive power suggest that olfactory is causally implicated in many medical The causal relationship between olfaction with memory dysfunction deserves particular attention because this sensory system has only direct projection centers. Mechanisms may underlie connections conditions include inflammation as well neuroanatomical environmental factors, all listed here also associated inflammation. enrichment shows efficacy for both prevention treatment, potentially mediated by decreasing

Language: Английский

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Factors influencing the time to COVID-19 antigen tests negative conversion among students at a Chinese university: a retrospective analysis

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Language: Английский

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