From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies DOI Creative Commons
James A. Wiseman, Kreesan Reddy, Birger Victor Dieriks

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102640 - 102640

Published: Dec. 1, 2024

This review provides an in-depth analysis of the complex role alpha-synuclein (α-Syn) in development α-synucleinopathies, with a particular focus on its structural diversity and resulting clinical variability. The ability α-Syn to form different strains or polymorphs undergo various post-translational modifications significantly contributes wide range symptoms observed disorders such as Parkinson's disease (PD), dementia Lewy bodies (DLB), multiple system atrophy (MSA), well lesser-known non-classical α-synucleinopathies. interaction between genetic predispositions environmental factors further complicates α-synucleinopathic pathogenesis, influencing disease-specific onset progression. Despite their common pathological hallmark accumulation, presentation progression α-synucleinopathies differ significantly, posing challenges for diagnosis treatment. intricacies pathology highlight critical need deeper understanding biological functions interactions within neuronal environment develop targeted therapeutic strategies. precise point at which aggregation transitions from being byproduct initial triggers active independent driver - through propagation acceleration pathogenic processes remains unclear. By examining across contexts, we illuminate dual both marker mediator disease, offering insights that could lead innovative approaches managing

Language: Английский

From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies DOI Creative Commons
James A. Wiseman, Kreesan Reddy, Birger Victor Dieriks

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102640 - 102640

Published: Dec. 1, 2024

This review provides an in-depth analysis of the complex role alpha-synuclein (α-Syn) in development α-synucleinopathies, with a particular focus on its structural diversity and resulting clinical variability. The ability α-Syn to form different strains or polymorphs undergo various post-translational modifications significantly contributes wide range symptoms observed disorders such as Parkinson's disease (PD), dementia Lewy bodies (DLB), multiple system atrophy (MSA), well lesser-known non-classical α-synucleinopathies. interaction between genetic predispositions environmental factors further complicates α-synucleinopathic pathogenesis, influencing disease-specific onset progression. Despite their common pathological hallmark accumulation, presentation progression α-synucleinopathies differ significantly, posing challenges for diagnosis treatment. intricacies pathology highlight critical need deeper understanding biological functions interactions within neuronal environment develop targeted therapeutic strategies. precise point at which aggregation transitions from being byproduct initial triggers active independent driver - through propagation acceleration pathogenic processes remains unclear. By examining across contexts, we illuminate dual both marker mediator disease, offering insights that could lead innovative approaches managing

Language: Английский

Citations

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