Spinal Cord Microglia in the Development of Touch

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(43), P. e1200242024 - e1200242024

Published: Oct. 23, 2024

Adaptive interactions with environmental stressors are crucial to survival and heavily reliant on detection perception of somatosensory modalities such as noxious innocuous touch, pressure, itch, proprioception. These processes hinge somatotopic, spatial, temporal patterning in the peripheral nervous system (PNS) central (CNS) during neurogenesis, synaptogenesis, postnatal circuit refinement. Perturbation development has been shown disrupt normal tactile processing, resulting touch avoidance, anxiety, cognitive dysfunction, aberrant social behaviors seen patients diagnosed neurodevelopmental conditions autism spectrum disorder (ASD; Tasnim et al., 2024). However, mechanisms underlying homeostatic spinal cord not well known.⇓ Figure 1. Microglial phagocytosis A-fiber synapses dorsal horn early (P1–3) influences mature synaptic density sensitivity touch. A , Typical leads a reduction cutaneous receptive field size B Tmem16f conditional knock-out (cKO) pups exhibit reduced microglial terminals laminae I-II (left). Adults retain extraneous VGLUT1+ synapses, large hindpaw fields specific dynamic hyporesponsive wide range (WDR) neurons encoding both static (right). Created BioRender (Eschenbacher Immature neuronal circuits have numerous superfluous connections between predominantly excitatory that spontaneous low-threshold firing properties. Consequently, these hyperexcitability, which is refined by targeted restructuring form sensitive tolerant enough perceive react stimuli properties intensities (Fig. 1 A; Abraira Ginty, 2013; Koch Fitzgerald, 2013). Although research into refinement brain activity-dependent synapse modification carried out microglia (Durán Laforet Schafer, … Correspondence should be addressed Kayla M. Eschenbacher at kaylae{at}genetics.utah.edu.

Language: Английский

Role of Neural Circuits in Cognitive Impairment

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Dec. 7, 2024

Language: Английский