Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(2), P. 255 - 255
Published: Jan. 30, 2023
A
high-fat
diet
is
one
of
the
causative
factors
obesity.
The
dietary
profile
fatty
acids
also
an
important
variable
in
developing
obesity,
as
saturated
are
more
obesogenic
than
monounsaturated
and
polyunsaturated
acids.
Overweight
obesity
inseparably
connected
with
excess
adipose
tissue
body,
characterized
by
hypertrophy
hyperplasia
fat
cells,
which
increases
risk
metabolic
syndrome.
Changes
observed
within
hypertrophic
adipocytes
result
elevated
oxidative
stress,
unfolded
protein
accumulation,
increased
endoplasmic
reticulum
(ER)
stress.
One
processes
involved
preservation
cellular
homeostasis
autophagy,
defined
intracellular
lysosome-dependent
degradation
system
that
serves
to
recycle
available
macromolecules
eliminate
damaged
organelles.
In
activation
autophagy
process
appears
be
regulated
different
types
This
review
describes
role
summarizes
current
understanding
effects
unsaturated
modulation
adipocytes.
Lipids in Health and Disease,
Journal Year:
2020,
Volume and Issue:
19(1)
Published: July 9, 2020
Abstract
Obesity
exhibits
a
correlation
with
metabolic
inflammation
and
endoplasmic
reticulum
stress,
promoting
the
progression
of
disease
such
as
diabetes,
hyperlipidemia,
hyperuricemia
so
on.
Adipose
tissue
macrophages
(ATMs)
are
central
players
in
obesity-associated
diseases.
Macrophages
involved
lipid
energy
metabolism
mitochondrial
function
adipocytes.
Macrophage
polarization
is
accompanied
by
shifting
between
glycolysis
oxidative
phosphorylation.
Here,
this
review
focuses
on
macrophage
linked
to
functional
phenotypes
an
emphasis
adipose
physiological
pathophysiological
processes.
In
particular,
interplay
ATMs
adipocytes
metabolism,
glycolysis,
OXPHOS,
iron
handing
even
interactions
nervous
system
have
been
reviewed.
Overall,
understanding
protective
pathogenic
roles
can
potentially
provide
strategies
prevent
treat
obesity-related
disorders.
Antioxidants,
Journal Year:
2019,
Volume and Issue:
8(1), P. 28 - 28
Published: Jan. 18, 2019
In
the
veterinary
sector,
many
papers
deal
with
relationships
between
inflammation
and
oxidative
stress.
However,
few
studies
investigate
mechanisms
of
action
oxidised
molecules
in
regulation
immune
cells.
Thus,
authors
often
assume
that
these
events,
sometime
leading
to
stress,
are
conserved
among
species.
The
aim
this
review
is
draw
state-of-the-art
current
knowledge
about
role
dietary
antioxidant
compounds
cell
functions
suggest
some
perspectives
for
future
investigations
animals
interest.
Food & Function,
Journal Year:
2021,
Volume and Issue:
12(11), P. 4768 - 4782
Published: Jan. 1, 2021
Excess
body
weight,
including
overweight
and
obesity,
is
one
of
the
major
factors
influencing
human
health,
plays
an
important
role
in
global
burden
disease.
Carotenoids
serve
as
precursors
vitamin
A-related
retinoids,
are
considered
to
have
potential
effects
on
many
diseases.
However,
influence
carotenoids
people
with
excess
weight
unclear.
This
meta-analysis
was
conducted
assess
or
obese
subjects
utilizing
available
evidence.
We
searched
PubMed,
Medline,
Cochrane
Library,
Web
Science
EMBASE
databases
up
September
2020.
Random
models
were
used
calculate
standard
mean
differences
(SMDs)
odds
ratios
(ORs)
their
95%
confidence
intervals
(95%
CIs).
A
total
seven
randomized
controlled
trials
eight
observational
studies
met
inclusion
criteria
contained
28
944
data
multiple
carotenoid
subgroups,
lycopene,
astaxanthin,
cryptoxanthin,
α-carotene,
β-carotene.
In
all
included
Randomized
Controlled
Trial
(RCT),
intervention
duration
20
days
at
shortest
16
weeks
longest,
range
doses
1.2-60
mg
d-1.
Our
study
found
that
insufficiency
serum
a
risk
factor
for
obesity
(OR
=
1.73,
CI
[1.57,
1.91],
p
<
0.001).
Moreover,
supplementation
significantly
associated
reductions
(SMD
-2.34
kg,
[-3.80,
-0.87]
0.001),
mass
index
decrease
(BMI,
SMD
-0.95
kg
cm-2,
[-1.88,
-0.01]
0.001)
waist
circumference
losses
(WC,
-1.84
cm,
[-3.14,
-0.54]cm,
summary,
show
promising
subjects.
Additional
from
large
clinical
needed.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(43), P. 13893 - 13903
Published: Oct. 20, 2022
The
antiobesity
efficacy
and
underlying
mechanisms
of
polysaccharides
extracted
from
Fu
brick
tea
(FBTP)
were
investigated.
An
8-week
administration
FBTP
dose-dependently
inhibited
increases
in
body
weight
weights
the
epididymal-,
retroperitoneal-
inguinal-white
adipose
tissues
stimulated
beige-fat
development
brown
tissue-derived
nonshivering
thermogenesis
high-fat
diet-induced
obese
mice.
protected
against
obesity-associated
abnormality
serum
adiponectin
leptin,
indicating
its
positive
regulation
energy
metabolism.
reversed
gut
dysbiosis
by
enriching
beneficial
bacteria,
for
example,
Lactobacillus,
Parabacteroides,
Akkermansia,
Bifidobacterium,
Roseburia.
Results
fecal
microbiota
transplantation
further
confirmed
that
FBTP-induced
microbial
shifts
contributed
to
browning
thermogenesis,
thereby
alleviating
host
adiposity,
glucose
homeostasis,
dyslipidemia,
related
hepatic
steatosis.
Our
study
demonstrates
great
potential
with
prebiotic-like
activities
preventing
obesity
metabolic
complications
via
microbiota-derived
enhancement
fat
burning
expenditures.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(2), P. 255 - 255
Published: Jan. 30, 2023
A
high-fat
diet
is
one
of
the
causative
factors
obesity.
The
dietary
profile
fatty
acids
also
an
important
variable
in
developing
obesity,
as
saturated
are
more
obesogenic
than
monounsaturated
and
polyunsaturated
acids.
Overweight
obesity
inseparably
connected
with
excess
adipose
tissue
body,
characterized
by
hypertrophy
hyperplasia
fat
cells,
which
increases
risk
metabolic
syndrome.
Changes
observed
within
hypertrophic
adipocytes
result
elevated
oxidative
stress,
unfolded
protein
accumulation,
increased
endoplasmic
reticulum
(ER)
stress.
One
processes
involved
preservation
cellular
homeostasis
autophagy,
defined
intracellular
lysosome-dependent
degradation
system
that
serves
to
recycle
available
macromolecules
eliminate
damaged
organelles.
In
activation
autophagy
process
appears
be
regulated
different
types
This
review
describes
role
summarizes
current
understanding
effects
unsaturated
modulation
adipocytes.