A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes

Lipids in Health and Disease, Journal Year: 2020, Volume and Issue: 19(1)

Published: July 9, 2020

Abstract Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of disease such as diabetes, hyperlipidemia, hyperuricemia so on. Adipose tissue macrophages (ATMs) are central players in obesity-associated diseases. Macrophages involved lipid energy metabolism mitochondrial function adipocytes. Macrophage polarization is accompanied by shifting between glycolysis oxidative phosphorylation. Here, this review focuses on macrophage linked to functional phenotypes an emphasis adipose physiological pathophysiological processes. In particular, interplay ATMs adipocytes metabolism, glycolysis, OXPHOS, iron handing even interactions nervous system have been reviewed. Overall, understanding protective pathogenic roles can potentially provide strategies prevent treat obesity-related disorders.

Language: Английский

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Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

Antioxidants, Journal Year: 2019, Volume and Issue: 8(1), P. 28 - 28

Published: Jan. 18, 2019

In the veterinary sector, many papers deal with relationships between inflammation and oxidative stress. However, few studies investigate mechanisms of action oxidised molecules in regulation immune cells. Thus, authors often assume that these events, sometime leading to stress, are conserved among species. The aim this review is draw state-of-the-art current knowledge about role dietary antioxidant compounds cell functions suggest some perspectives for future investigations animals interest.

Language: Английский

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The association between carotenoids and subjects with overweight or obesity: a systematic review and meta-analysis

Food & Function, Journal Year: 2021, Volume and Issue: 12(11), P. 4768 - 4782

Published: Jan. 1, 2021

Excess body weight, including overweight and obesity, is one of the major factors influencing human health, plays an important role in global burden disease. Carotenoids serve as precursors vitamin A-related retinoids, are considered to have potential effects on many diseases. However, influence carotenoids people with excess weight unclear. This meta-analysis was conducted assess or obese subjects utilizing available evidence. We searched PubMed, Medline, Cochrane Library, Web Science EMBASE databases up September 2020. Random models were used calculate standard mean differences (SMDs) odds ratios (ORs) their 95% confidence intervals (95% CIs). A total seven randomized controlled trials eight observational studies met inclusion criteria contained 28 944 data multiple carotenoid subgroups, lycopene, astaxanthin, cryptoxanthin, α-carotene, β-carotene. In all included Randomized Controlled Trial (RCT), intervention duration 20 days at shortest 16 weeks longest, range doses 1.2-60 mg d-1. Our study found that insufficiency serum a risk factor for obesity (OR = 1.73, CI [1.57, 1.91], p < 0.001). Moreover, supplementation significantly associated reductions (SMD -2.34 kg, [-3.80, -0.87] 0.001), mass index decrease (BMI, SMD -0.95 kg cm-2, [-1.88, -0.01] 0.001) waist circumference losses (WC, -1.84 cm, [-3.14, -0.54]cm, summary, show promising subjects. Additional from large clinical needed.

Language: Английский

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Fu Brick Tea Polysaccharides Prevent Obesity via Gut Microbiota-Controlled Promotion of Adipocyte Browning and Thermogenesis

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(43), P. 13893 - 13903

Published: Oct. 20, 2022

The antiobesity efficacy and underlying mechanisms of polysaccharides extracted from Fu brick tea (FBTP) were investigated. An 8-week administration FBTP dose-dependently inhibited increases in body weight weights the epididymal-, retroperitoneal- inguinal-white adipose tissues stimulated beige-fat development brown tissue-derived nonshivering thermogenesis high-fat diet-induced obese mice. protected against obesity-associated abnormality serum adiponectin leptin, indicating its positive regulation energy metabolism. reversed gut dysbiosis by enriching beneficial bacteria, for example, Lactobacillus, Parabacteroides, Akkermansia, Bifidobacterium, Roseburia. Results fecal microbiota transplantation further confirmed that FBTP-induced microbial shifts contributed to browning thermogenesis, thereby alleviating host adiposity, glucose homeostasis, dyslipidemia, related hepatic steatosis. Our study demonstrates great potential with prebiotic-like activities preventing obesity metabolic complications via microbiota-derived enhancement fat burning expenditures.

Language: Английский

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Fatty Acids as Potent Modulators of Autophagy Activity in White Adipose Tissue

Biomolecules, Journal Year: 2023, Volume and Issue: 13(2), P. 255 - 255

Published: Jan. 30, 2023

A high-fat diet is one of the causative factors obesity. The dietary profile fatty acids also an important variable in developing obesity, as saturated are more obesogenic than monounsaturated and polyunsaturated acids. Overweight obesity inseparably connected with excess adipose tissue body, characterized by hypertrophy hyperplasia fat cells, which increases risk metabolic syndrome. Changes observed within hypertrophic adipocytes result elevated oxidative stress, unfolded protein accumulation, increased endoplasmic reticulum (ER) stress. One processes involved preservation cellular homeostasis autophagy, defined intracellular lysosome-dependent degradation system that serves to recycle available macromolecules eliminate damaged organelles. In activation autophagy process appears be regulated different types This review describes role summarizes current understanding effects unsaturated modulation adipocytes.

Language: Английский

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