Dietary intake of probiotic fermented milk benefits the gut and reproductive health in mice fed with an obesogenic diet DOI

Mohd. Akram,

Syed Azmal Ali, Pradip V. Behare

et al.

Food & Function, Journal Year: 2021, Volume and Issue: 13(2), P. 737 - 752

Published: Dec. 6, 2021

Probiotics have been suggested as alternatives to pharmacological drugs in the treatment of a variety medical problems, including obesity management, which is often linked low sperm production. Also, probiotic fermented products are known boost host immune response, immunosenescence, infection tolerance, and redox homeostasis, but their direct role male fertility has less investigated. This study assessed effect two strains, L. fermentum NCDC 400 rhamnosus 610, fructooligosaccharide (FOS) milk supplementation. We identified significantly reduced oxidative stress markers plasma liver HF diet-fed animals. determined key testicular enzymes steroidogenic pathway genes StAR, P450scc, 17βHSD maintaining testosterone concentration restoring structures. In conclusion, present work illustrated ability both probiotics 610 regulatory agents with beneficial effects on weight loss endogenous substantially improved motility diet-induced (DIO) models. Our findings indicate that supplementation may be an alternative for preventing other related metabolic syndromes.

Language: Английский

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature DOI Creative Commons
Andrew Peel, Anmol Saini, Joshua C. Deluao

et al.

Andrology, Journal Year: 2023, Volume and Issue: 11(8), P. 1635 - 1652

Published: Feb. 15, 2023

Obesity prevalence worldwide is increasing significantly. Whilst maternal obesity has clear detrimental impacts on fertility, pregnancy and foetal outcomes, more recently there been an focus the role of paternal in human fertility. Recent meta-analyses have indicated that men negatively affects basic sperm parameters such as count, concentration motility, increases incidence infertility reduces chances conception. Sperm DNA damage, typically characterised by strand breaks oxidation nucleotides, a specialised marker quality independently associated with recurrent miscarriage, reduced assisted reproduction success increased mutational loads subsequent offspring. Whilst, are still conflicting data humans to association evidence from rodent models clear, indicating male damage. Human often because large heterogeneity amongst studies, use body mass index indicator methods used for detection Furthermore, comorbidities (i.e., heat stress, adipokines, insulin resistance, changes lipids, hypogonadism obstructive sleep apnoea) also damage not always modified obesity, may provide causative link discrepancies studies. In this review, we update literature regarding associations between We further discuss potential reasons outline possible direct indirect mechanisms resulting obesity. Finally, summarise intergenerational through linage how contribute transmission.

Language: Английский

Citations

17
Combination of high-fat diet and cadmium impairs testicular spermatogenesis in an m6A-YTHDF2-dependent manner DOI

Yong-Wei Xiong,

Lulu Tan,

Jin Zhang

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 313, P. 120112 - 120112

Published: Sept. 6, 2022

Language: Английский

Citations

27
Dietary trends and the decline in male reproductive health DOI
Joseph Whittaker

HORMONES, Journal Year: 2023, Volume and Issue: 22(2), P. 165 - 197

Published: Feb. 2, 2023

Language: Английский

Citations

15
Obesity is associated with quality of sperm parameters in men with infertility: a cross-sectional study DOI Creative Commons

Mina Darand,

Zahra Salimi,

Moloud Ghorbani

et al.

Reproductive Health, Journal Year: 2023, Volume and Issue: 20(1)

Published: Sept. 12, 2023

Previous studies examined the effects of obesity on sperm parameters and reported inconsistent results. Thus, present study aimed to evaluate association between quality in infertile men.The cross-sectional evaluated 218 men aged 20-50. To this end, 168-item food frequency questionnaire (FFQ) was utilized dietary intake. The anthropometric biochemical variables were using standard methods. Further, controlled linear regression for potential confounders.The normal morphology had a significant inverse with BMI [adjusted β - 0.074, CI (- 0.141 0.008), P = 0.029] WC 0.026, 0.051 0.001), 0.038]. Additionally, visceral fat marginal 0.065, 0.138 0.079] non-progressive motility 0.241, 0.495 0.014), 0.063].Even though results indicated that obesity, abdominal associations morphology, more mechanism-based should be conducted confirm these findings.

Language: Английский

Citations

13
The Molecular Basis of Male Infertility in Obesity: A Literature Review DOI Open Access
Biji Thomas George, Malay Jhancy, Rajani Dube

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 179 - 179

Published: Dec. 22, 2023

The rising incidence of obesity has coincided with levels poor reproductive outcomes. molecular basis for the association infertility in obese males is now being explained through various mechanisms. Insulin resistance, hyperglycemia, and changes serum gonadal concentrations adipokines, like leptin, adiponectin, resistin, ghrelin have been implicated as causes male males. effects hypogonadism form a vicious cycle whereby dysregulation hypothalamic-pituitary-testicular axis-due to effect release multiple mediators, thus decreasing GnRH from hypothalamus-causes decreases LH FSH levels. This leads lower testosterone, which further increases adiposity because increased lipogenesis. Cytokines such TNF-α interleukins, sirtuins, other inflammatory mediators reactive oxygen species are known affect fertility adults. There evidence that parental can be transferred subsequent generations offspring epigenetic marks. Thus, negative expressions linked marks altered previous generations. interesting aspect these reverted by removing triggering factors. These positive modifications also transmitted

Language: Английский

Citations

13
Clinical factors impacting microdissection testicular sperm extraction success in hypogonadal men with nonobstructive azoospermia DOI Creative Commons
Sandro C. Esteves, Arnold Peter Paul Achermann, Ricardo Miyaoka

et al.

Fertility and Sterility, Journal Year: 2024, Volume and Issue: 122(4), P. 636 - 647

Published: June 22, 2024

To explore factors influencing microdissection testicular sperm extraction (micro-TESE) success in hypogonadal men with nonobstructive azoospermia (NOA).

Language: Английский

Citations

5
Perfluorooctane sulfonate (PFOS) disrupts testosterone biosynthesis via CREB/CRTC2/StAR signaling pathway in Leydig cells DOI
Lianglin Qiu, Hongxia Wang,

Tianyi Dong

et al.

Toxicology, Journal Year: 2020, Volume and Issue: 449, P. 152663 - 152663

Published: Dec. 24, 2020

Language: Английский

Citations

36
Semen damage contributed over 50 % to air-pollutant-induced infertility: A prospective cohort study of 3940 men in China DOI
Ying Guo, Qing Chen, Yu Zhan

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 885, P. 163532 - 163532

Published: April 23, 2023

Language: Английский

Citations

13
Male obesity is associated with sperm telomere shortening and aberrant mRNA expression of autophagy-related genes DOI Creative Commons
Pourya Raee, Zahra Shams Mofarahe, Hamid Nazarian

et al.

Basic and Clinical Andrology, Journal Year: 2023, Volume and Issue: 33(1)

Published: May 24, 2023

Obesity is regarded a global public health crisis. It has been implicated in variety of problems, but when it comes to male fertility, how and what extent obesity affects are poorly understood. Accordingly, semen samples from 32 individuals with (body mass index (BMI) ≥ 30 kg/m2) normal weight (BMI: 18.5-25 were obtained. Here, for the first time, we examined association between obesity, relative sperm telomere length (STL) autophagy-related mRNA levels such as Beclin1, AMPKa1, ULK1, BAX, BCL2. Each group was also evaluated conventional parameters, apoptotic changes, DNA fragmentation (DFI), chromatin maturation, reactive oxygen species (ROS) levels.Based on our findings, there marked reduction STL compared normal-weight group. We found significant negative correlation age, BMI, DFI, percentage immature chromatin, intracellular ROS patients obesity. In group, only negatively correlated DFI levels. Regarding expression, considerable upregulation BCL2 be associated decline volume, total count, progressive motility, viability comparison individuals. Furthermore, considerably higher percentages late-stage apoptosis, elevated levels.According shortening aberrant expression. should emphasized that may an indirect consequence due oxidative stress condition. Nevertheless, further investigation required more comprehensive understanding.RéSUMé: CONTEXTE: L’obésité est considérée comme une crise mondiale de santé publique. Elle été impliquée dans divers problèmes ; mais quand il s’agit la fertilité masculine, comment et quelle mesure l’obésité affecte cette restent mal compris. En conséquence, des échantillons sperme hommes obèses (indice masse corporelle (IMC) kg/m²) ayant un poids (IMC : 18,5 à 25 ont recueillis. A examiné étude, pour première fois, l’association entre l’obésité, longueur télomères spermatozoïdes (LTS), les taux d’ARNm liés l’autophagie tels que BAX Chaque groupe également évalué paramètres conventionnels du sperme, changements apoptotiques spermatozoïdes, l’indice l’ADN maturation chromatine niveaux d’espèces réactives l’oxygène (ROS). RéSULTATS: Il y eut réduction marquée LTS chez par rapport ceux normal. Nous avons trouvé corrélation négative significative l’âge, l’IMC, le pourcentage avec intracellulaires obèses. Dans d’hommes normal, n’était corrélée négativement qu’avec intracellulaires. ce qui concerne l’expression l’ARNm, avait régulation positive considérable ULK1 s’est avérée être associée baisse volume nombre mobilité viabilité aux outre, était pourcentages considérablement plus élevés immature, d’apoptose stade avancé, ROS. CONCLUSION: Selon nos résultats, au raccourcissement expression aberrante l’autophagie. convient souligner peut conséquence indirecte en raison oxydatif associé maladie. Néanmoins, études approfondies sont nécessaires compréhension complète.

Citations

11
Trends in sperm quality by computer-assisted sperm analysis of 49,189 men during 2015–2021 in a fertility center from China DOI Creative Commons

Yanquan Li,

Tingting Lu,

Zhengmu Wu

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 12, 2023

Background Sperm quality, including semen volume, sperm count, concentration, and total progressive motility (collectively, “semen parameters”), has declined in the recent decades. Computer-assisted analysis (CASA) provides kinematic parameters, temporal trends of which remain unclear. Our objective is to examine trend both parameters Shanghai, China, years. Methods This retrospective study analyzed 49,819 men attending our reproductive center by using CASA during 2015–2021. The sample was divided into two groups: samples that surpassed WHO guideline (2010) low reference limits (“above limit” group, ARL; n = 24,575) did not (“below BRL; 24,614). One-way variance, Kruskal–Wallis test, independent t -test, covariance were used assess differences among groups. Year, age, abstinence time included multiple linear regression model ARL group adjust confounders depict quality. Results Among all BRL groups, age subjects increased Semen volume count showed tendency with years sample, subgroup or time, whereas velocities on contrary. adjusting for confirmed these trends. (β1= −0.162; CI: −0.172, −0.152), −9.97; −10.813, −9.128), concentration (β1 −0.535; −0.772, −0.299), −1.751; −1.830, −1.672), −1.12; −0.201, −0.145) decreased year, curvilinear line velocity (VCL) 3.058; 2.912, 3.203), straight (VSL) 2.075; 1.990, 2.161), average path (VAP) 2.305; 2.224, 2.386) over (all p < 0.001). In addition, VCL, VSL, VAP significantly time. Conclusion declined, We propose that, although motion increased, suggesting a possible compensatory mechanism male fertility.

Language: Английский

Citations

11