Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(18), P. 5610 - 5623
Published: April 27, 2022
Pu-erh
tea
is
a
healthy
beverage
rich
in
phytochemicals,
and
its
effect
on
the
risk
of
inducing
circadian
rhythm
disorders
(CRD)
unclear.
In
this
study,
mice
were
given
water
or
0.25%
(w/v)
for
7
weeks,
followed
by
40
day
disruption
light/dark
cycle.
CRD
caused
dysregulation
neurotransmitter
secretion
clock
gene
oscillations,
intestinal
inflammation,
microbes
metabolites.
boosted
indole
5-hydroxytryptamine
pathways
tryptophan
metabolism
via
gut-liver-brain
axis.
Furthermore,
metabolites
(e.g.,
IAA,
Indole,
5-HT)
enhanced
hepatic
glycolipid
down-regulated
oxidative
stress
improving
brain
hormone
release.
Tryptophan
bile
acids
also
promoted
liver
lipid
inhibited
inflammation
(MyD88/NF-κB)
enterohepatic
circulation.
Collectively,
has
potential
to
prevent
promoting
5-HT
signaling
interactions
BMC Gastroenterology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 12, 2025
Imbalance
in
the
gut
microbiota
is
a
key
factor
pathogenesis
of
non-alcoholic
fatty
liver
disease
(NAFLD)
and
fibrosis.
The
Dietary
Index
for
Gut
Microbiota
(DI-GM)
integrates
potential
relationship
between
diet
diversity.
This
study
aims
to
investigate
association
DI-GM
risk
NAFLD
fibrosis,
providing
theoretical
support
dietary
intervention
strategies.
utilized
data
from
NHANES
2017–2020,
including
6,181
eligible
adult
participants.
fibrosis
was
assessed
using
quartiles,
multivariate
logistic
regression,
restricted
cubic
spline
(RCS)
analysis.
Subgroup
analysis
performed
explore
predictive
role
different
populations.
All
analyses
were
weighted
ensure
representativeness
results.
negatively
associated
with
risks
As
scores
increased,
significantly
decreased
(52.81%,
43.16%,
40.40%,
31.98%,
p
<
0.05;
17.52%,
9.04%,
7.21%,
6.78%,
0.05).
Multivariate
regression
revealed
that,
unadjusted
model
(Model
1),
each
unit
increase
DI-GM,
by
6.9%
(OR
=
0.931,
95%
CI:
0.886–0.979,
0.001),
while
15.6%
0.844,
0.757–0.941,
In
quartile
analysis,
individuals
highest
(Q4)
had
58%
lower
compared
those
lowest
(Q1)
0.42,
0.219–0.806,
0.001).
results
remained
significant
even
after
adjusting
covariates.
RCS
showed
that
nonlinear
inflection
points
at
2
5,
indicating
enhanced
protective
effects.
reveals
negative
highlighting
healthy
patterns
prevention
management
through
modulation,
basis
interventions.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(11), P. 3808 - 3808
Published: Oct. 26, 2021
In
well-developed
countries,
people
have
started
to
pay
additional
attention
preserving
healthy
dietary
habits,
as
it
has
become
common
knowledge
that
neglecting
them
may
easily
lead
severe
health
impairments,
namely
obesity,
malnutrition,
several
cardiovascular
diseases,
type-2
diabetes,
cancers,
hypertensions,
and
inflammations.
Various
types
of
functional
foods
were
developed
are
enriched
with
vitamins,
probiotics,
prebiotics,
fibers
in
order
develop
a
balanced
diet
improve
the
general
consumers.
Numerous
kinds
fiber
found
nature,
but
they
often
noticeable
undesired
impact
on
sensory
features
or
digestive
system.
This
led
development
modified
fibers,
which
little
no
taste
added
to.
At
same
time,
possess
all
benefits
similar
those
such
regulating
gastrointestinal
microbiota
composition,
increasing
satiety,
improving
metabolic
parameters
human.
following
review,
evidence
supporting
prebiotic
properties
starches,
particularly
resistant
starches
their
derivatives,
dextrins,
was
assessed
deliberated,
allowed
drawing
an
interesting
conclusion
subject.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
63(18), P. 3236 - 3253
Published: Oct. 26, 2021
While
the
incidence
of
obesity
keeps
increasing
in
both
adults
and
children
worldwide,
its
complications
remain
major
threatens
to
human
health.
Over
past
decades,
accumulating
evidence
has
demonstrated
importance
microorganisms
their
metabolites
pathogenesis
related
diseases.
There
also
is
a
significant
body
validating
efficacy
microbial
based
therapies
for
managing
various
In
this
review,
we
collected
key
information
pertinent
obesity-related
bacteria,
fermentation
substrates
generated
by
studies
involving
humans
and/or
mice.
We
then
briefly
described
possible
molecular
mechanisms
which
cause
or
inhibit
with
focus
on
metabolites.
Lastly,
summarized
advantages
disadvantages
utilization
probiotics,
plant
extracts,
exercise
controlling
obesity.
speculated
that
new
targets
combined
approaches
(e.g.
diet
exercise)
could
lead
more
precise
prevention
alleviation
future
clinical
research
implications.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(18), P. 5610 - 5623
Published: April 27, 2022
Pu-erh
tea
is
a
healthy
beverage
rich
in
phytochemicals,
and
its
effect
on
the
risk
of
inducing
circadian
rhythm
disorders
(CRD)
unclear.
In
this
study,
mice
were
given
water
or
0.25%
(w/v)
for
7
weeks,
followed
by
40
day
disruption
light/dark
cycle.
CRD
caused
dysregulation
neurotransmitter
secretion
clock
gene
oscillations,
intestinal
inflammation,
microbes
metabolites.
boosted
indole
5-hydroxytryptamine
pathways
tryptophan
metabolism
via
gut-liver-brain
axis.
Furthermore,
metabolites
(e.g.,
IAA,
Indole,
5-HT)
enhanced
hepatic
glycolipid
down-regulated
oxidative
stress
improving
brain
hormone
release.
Tryptophan
bile
acids
also
promoted
liver
lipid
inhibited
inflammation
(MyD88/NF-κB)
enterohepatic
circulation.
Collectively,
has
potential
to
prevent
promoting
5-HT
signaling
interactions
