How to manage weight loss in women with obesity and PCOS seeking fertility?

Clinical Endocrinology, Journal Year: 2022, Volume and Issue: 97(2), P. 208 - 216

Published: March 23, 2022

Obesity exacerbates the phenotype of polycystic ovarian syndrome (PCOS) including infertility as well reducing efficacy and access to fertility treatments. Weight management is, therefore, a key component treatment for women with PCOS coexistent obesity. Many describe significant difficulty losing weight options are limited. The first-line is lifestyle interventions though loss any impact on No one dietary strategy can be preferentially recommended based current evidence. While very low energy diets result in evidence Pharmacotherapy, range treatments marked there some improved rates conception spontaneous response assisted reproduction treatment. As pharmacotherapy, data regarding bariatric surgery largely from nonrandomized studies anticipated improve available prevents firm conclusions. Clinicians patients must consider magnitude targeted required timeline when deciding upon personalized strategy. should confident targeting most appropriate early patient's avoid unnecessary delays.

Language: Английский

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The Molecular Basis of Male Infertility in Obesity: A Literature Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 179 - 179

Published: Dec. 22, 2023

The rising incidence of obesity has coincided with levels poor reproductive outcomes. molecular basis for the association infertility in obese males is now being explained through various mechanisms. Insulin resistance, hyperglycemia, and changes serum gonadal concentrations adipokines, like leptin, adiponectin, resistin, ghrelin have been implicated as causes male males. effects hypogonadism form a vicious cycle whereby dysregulation hypothalamic-pituitary-testicular axis-due to effect release multiple mediators, thus decreasing GnRH from hypothalamus-causes decreases LH FSH levels. This leads lower testosterone, which further increases adiposity because increased lipogenesis. Cytokines such TNF-α interleukins, sirtuins, other inflammatory mediators reactive oxygen species are known affect fertility adults. There evidence that parental can be transferred subsequent generations offspring epigenetic marks. Thus, negative expressions linked marks altered previous generations. interesting aspect these reverted by removing triggering factors. These positive modifications also transmitted

Language: Английский

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The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

BMC Women s Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 15, 2023

Abstract Background Obesity is a pressing public health risk issue worldwide. Women, in particular, face higher of obesity. Recent research has highlighted the association between obesity and female sexual dysfunction. Therefore, objective this study to investigate global prevalence dysfunction obese overweight women through systematic review meta-analysis. Methods In study, search was conducted across electronic databases, including PubMed, Scopus, Web Science, Embase, ScienceDirect, Google Scholar. The aimed identify studies published December 2000 August 2022 that reported metabolic syndrome's impact on Results included nine with sample size 1508 women. I 2 heterogeneity index indicated high (I : 97.5). As result, random effects method used analyze data. Based meta-analysis, as 49.7% (95%CI: 35.8–63.5). Furthermore, comprised five involving 1411 test demonstrated 96.6). Consequently, model results. According 26.9% (95% CI: 13.5–46.5). Conclusion results it been being particularly an important factor affecting women's policymakers must acknowledge significance order raise awareness society about its detrimental effect population.

Language: Английский

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Normal weight obesity is associated with lower AFC and adverse IVF outcomes

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Body weight could be classified into underweight, normal and overweight according to percentage of body fat (%BF), obesity (NWO) is defined as a BMI but high %BF. While the impact NWO in women fecundity remain unknow. Therefore, this study aimed investigate associations between %BF reproductive outcomes among

Language: Английский

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Epidemiología de la fertilidad y factores que la afectan

EMC - Ginecología-Obstetricia, Journal Year: 2025, Volume and Issue: 61(1), P. 1 - 12

Published: Feb. 21, 2025

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Menstrual and sexual functions in female patients after sleeve gastrectomy due to obesity: obesity and sexual function

Archives of Gynecology and Obstetrics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Purpose Obesity is a systemic condition that increasingly common. negatively affects sexual function and menstrual regularity. Therefore, losing excess weight important for women's health. Methods The change in body mass index (BMI) loss (EWL) of sexually active female patients who underwent laparoscopic sleeve gastrectomy (LSG) were evaluated by general surgeon. preoperative postoperative periods compared gynecologist using the survey method patterns, dysmenorrhea complaints, if any, with Female Sexual Function Scale (FSFI). Results study included 55 mean ± standard deviation BMI on day operation 45.32 5.82 kg/m2. In first year, significantly reduced to 27.88 1.99 ( p < 0.001). percentage EWL at end 1 year was 73.09 19.74 after LSG. median (range) FSFI score 26.30 (22.70–27.70). One LSG, improved 34.50 (30.20–35.30) Compared period before surgery, frequency intercourse increased from two-to-three times week Conclusion Women's desires are fundamental human right contribute well-being. Thus, it treat dysfunction. results present demonstrate significant improvement dysfunctions LSG an effective procedure may be recommended obese women dysfunction problems. Graphical abstract

Language: Английский

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Dietary supplementation of male mice with inorganic, organic or nanoparticle selenium preparations: evidence supporting a putative gut-thyroid-male fertility axis

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 25, 2025

Selenium (Se) is linked to physiological homeostasis. Male mice (n = 8/group) were fed control (AIN93G) or diets enriched in sodium selenite (NaSe, 5.6 ppm), methylselenocysteine (Met, 4.7 diphenyl diselenide (DPDS, 14.2 nanoselenium (NanoSe, 2.7 ppm); dietary Se ascertained by inductively-coupled plasma mass spectrometry. At 4 weeks testes, sperm, thyroids, blood and stool collected assess histoarchitecture, circulating hormones (thyroxine, T4; triiodothyronine, T3; thyroid stimulating hormone, TSH) gut microbiome (16S rRNAV3-V4 amplicon sequencing). Supplemented NaSe, Met, NanoSe increased testosterone testis glutathione peroxidases (GPx-1/4) while testicular superoxide dismutase catalase slightly the group indicating a selective antioxidant response. Overall, NaSe enhanced male reproductive factors. All thyroids isolated from Se-supplemented contained marginal vacuoles lower follicle area vs control. Nano-Se thyroidiodothyronine deiodinase-1 (DIO1) expression however, GPx-1/4 remained unchanged. DPDSl T3/T4 ratio, TSH was Microbiome analyses showed that most efficacious altering composition (judged α-diversity, Shannon index taxon richness) diet greatest overall change α-diversity. Dietary supplementation, particularly encapsulated NanoSe, may improve fertility factors enhancing gut-thyroid-fertility axis.

Language: Английский

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Immunological effects of GLP-1 analogs on female reproduction: therapeutic perspectives for infertility and recurrent pregnancy loss

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 169, P. 104538 - 104538

Published: May 8, 2025

Language: Английский

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Patient perceptions of body mass index restrictions limiting fertility care for women with high body mass index

Reproductive BioMedicine Online, Journal Year: 2023, Volume and Issue: 47(2), P. 103210 - 103210

Published: April 9, 2023

Language: Английский

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Effectiveness of non-pharmaceutical intervention on sperm quality: a systematic review and network meta-analysis

Aging, Journal Year: 2023, Volume and Issue: 15(10), P. 4253 - 4268

Published: May 17, 2023

Infertility affects about 10% of the world's population and has been recognized by WHO as a global public health problem. The aim this network meta-analysis was to investigate efficacy non-pharmaceutical interventions on sperm quality. All randomized clinical trials (RCTs) from PubMed, MEDLINE, Embase, China national knowledge infrastructure (CNKI), Wanfang database, Cochrane Library databases evaluating effectiveness semen parameters using meta-analyses. Results ω-3 fatty acid, lycopene, acupuncture, vitamin suggested evident advantages in improving concentration (MD, 9.93 (95% CI, 7.21 12.65)), 8.79 2.67 14.91)), 5.40 2.32 8.49)) 3.82 0.70 6.94) respectively). Acupuncture significant advantage over placebo total motility 17.81 10.32 25.29)), effect lycopene obviously greater than that 19.91 2.99 36.83)). Lycopene, Coenzyme Q10 (CoQ10), forward 8.64 1.15 16.13), MD, 5.28 2.70 7.86), 3.95 3.23 4.67), 3.50 2.21 4.79)) 2.38 0.96 3.80) This review establishes interventions, particularly exercise, acids, CoQ10, zinc, vitamins, selenium, carnitine, or foods rich these supplements, profitably improve quality may be used treat male infertility.

Language: Английский

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