Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and healthcare

hLife, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Melatonin supplementation: new insights into health and disease

Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(2)

Published: April 25, 2025

Language: Английский

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Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis

BioData Mining, Journal Year: 2024, Volume and Issue: 17(1)

Published: Feb. 28, 2024

Abstract Purpose Epistasis, the interaction between two or more genes, is integral to study of genetics and present throughout nature. Yet, it seldom fully explored as most approaches primarily focus on single-locus effects, partly because analyzing all pairwise higher-order interactions requires significant computational resources. Furthermore, existing methods for epistasis detection only consider a Cartesian (multiplicative) model terms. This likely limiting epistatic can evolve produce varied relationships genetic loci, some complex not linearly separable. Methods We new algorithms coefficients standard regression models that permit many terms loci efficient memory usage. The are given two-way three-way may be generalized higher order epistasis. Statistical tests also provided. an matrix based algorithm permutation testing offer proof experimental evidence look at have main effects justified. Given efficiency algorithm, we applied method rat data set mouse set, with least 10,000 1,000 samples each, using XOR explore body mass index. Results reveals although found exhibit statistical overlap in rats, pairs mostly distinct. Further, greater both sets almost mice identified XOR. In involved under enriched biologically relevant pathways. Conclusion Our results species show would been undetected if one was applied, providing should implemented occur living systems.

Language: Английский

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Association between hedonic hunger and body mass index in adults: A systematic review and meta-analysis

Appetite, Journal Year: 2024, Volume and Issue: 199, P. 107395 - 107395

Published: May 7, 2024

Language: Английский

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Melatonin reduces IL‐33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(2)

Published: Feb. 1, 2023

Chronic rhinosinusitis (CRS) is a chronic mucosal inflammation of the nasal cavity and sinuses. It classified into CRS without polyps with (CRSwNP). CRSwNP has high recurrence, especially massive eosinophil infiltration which mediated by type 2 inflammatory response. Melatonin hormone secreted pineal gland, it powerful antioxidant anti-inflammatory effects in addition to regulating biological rhythms. There are no studies on melatonin for treatment CRS, so we aimed explore whether could be used CRS. In this study, treat cell model Subsequently, MTT assay was performed examine viability human epithelial cells (HNEpCs), reactive oxygen species (ROS) kit detect ROS production, malondialdehyde (MDA) MDA content culture supernatant, an apoptosis Western blot analysis apoptosis. The expressions Nrf2, HO-1, IL-33, TSLP, IL-25 were detected analysis. improved HNEpCs, reduced lipopolysaccharide-induced ROS, content, inhibited their More importantly, expression IL-33 important phenomenon CRSwNP. protects HNEpCs from damage reduces TSLP HNEpCs.

Language: Английский

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The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and treatment options

Obesity Reviews, Journal Year: 2022, Volume and Issue: 23(10)

Published: June 29, 2022

Summary Obesity is associated with changes in the resolution of acute inflammation that contribute to clinical complications. The exact mechanisms underlying unresolved obesity are not fully understood. Adipocyte death leads pro‐inflammatory adipose tissue macrophages, stimulating additional adipocyte apoptosis. Thus, a complex and tightly regulated process inhibit maintain homeostasis after apoptosis needed health. In normal condition, specialized phagocytic (efferocytosis) performs this function, clearing necrotic apoptotic cells (ACs) controlling inflammation. For efficient continued efferocytosis, phagocytes must internalize multiple ACs physiological conditions handle excess metabolic burden tissue. obesity, control lost can be an important hallmark disease. regard, deficiency efferocytosis delayed result ongoing inflammation, immune system dysfunction, insulin resistance obesity. Hence, clearance by M2 macrophages could limit long‐term ensue complications, such as cardiovascular disease diabetes. This review elaborates upon molecular identify regulators improve reduce obesity‐related use pharmacological agents regular exercise.

Language: Английский

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Melatonin ameliorates myocardial infarction in obese diabetic individuals: The possible involvement of macrophage apoptotic factors

Journal of Pineal Research, Journal Year: 2022, Volume and Issue: 74(2)

Published: Dec. 2, 2022

Abstract In recent days, the hike in obesity‐mediated epidemics across globe and prevalence of obesity‐induced cardiovascular disease has become one chief grounds for morbidity mortality. This epidemic‐driven detrimental events cardiac tissues start with altered distribution metabolism pattern high‐density lipoprotein low‐density (LDL) leading to cholesterol (oxidized LDL) deposition on arterial wall atherosclerotic plaque generation, followed by vascular spasms infarction. Subsequently, obesity‐triggered metabolic malfunctions induce free radical generation which may further trigger pro‐inflammatory signaling nuclear factor kappa‐light‐chain‐enhancer activated B cells transcriptional factor, thus inducing interferon‐gamma, tumor necrosis factor‐alpha, inducible nitric oxide synthase. terrifying cardiomyopathy can be aggravated type 2 diabetes mellitus, thereby making obese diabetic patients prone toward development myocardial infarction (MI) or stroke comparison their nondiabetic counterparts. The accelerated oxidative stress response induced cardiomyocyte hypertrophy, apoptosis individuals, causing progression athero‐thrombotic disease. Being an efficient antioxidative anti‐inflammatory indolamine, melatonin effectively inhibits lipid peroxidation, reactions, resolving radical‐induced damages along maintaining antioxidant reservoir preserve integrity. Prolonged treatment maintains balanced body weight serum total concentration inhibiting synthesis promoting catabolism. Additionally, promotes macrophage polarization state, providing a proper shield during recovery period. Therefore, protective role homeostasis blocking rupture could targeted as possible therapeutic strategy management acute MI. review aimed at orchestrating efficacy ameliorating irrevocable damage obesity–diabetes correlation.

Language: Английский

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Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation

Published: Feb. 20, 2024

Sleep fragmentation (SF) can increase inflammation and production of reactive oxygen species (ROS), leading to metabolic dysfunction. SF is associated with adipose tissue insulin resistance. Several studies suggested that melatonin may have beneficial effects by activating AMP-activated protein kinase (AMPK). However, it unclear whether affects the AMPK signaling pathway in SF-induced Therefore, we hypothesize induces impairment white (WAT), as well altered intracellular homeostasis. We further these conditions could be improved treatment. conducted an experiment using adult male C57BL/6 mice, which were divided into three groups: control, SF, treatment (SF+Mel). The mice housed chambers, while SF+Mel received daily oral melatonin. After 12 weeks, glucose tolerance test, inflammation, assessments performed. showed increased weight gain, impaired regulation, decreased WAT compared controls. Melatonin significantly outcomes mitigating dysfunction, downregulation tissue. therapeutic efficacy against cardiometabolic impairments due its ability restore homeostatic pathways.

Language: Английский

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Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 470 - 470

Published: March 7, 2024

Sleep fragmentation (SF) can increase inflammation and production of reactive oxygen species (ROS), leading to metabolic dysfunction. SF is associated with adipose tissue insulin resistance. Several studies have suggested that melatonin may beneficial effects due activating AMP-activated protein kinase (AMPK). However, it unclear whether affects the AMPK signaling pathway in SF-induced Therefore, we hypothesize induces impairment white (WAT), as well altered intracellular homeostasis. We further these conditions could be improved by treatment. conducted an experiment using adult male C57BL/6 mice, which were divided into three groups: control, SF, treatment (SF+Mel). The mice housed chambers, while SF+Mel received daily oral melatonin. After 12 weeks, glucose tolerance tests, assessments performed. showed increased weight gain, impaired regulation, inflammation, decreased WAT compared controls. Melatonin significantly outcomes mitigating dysfunction, downregulation tissue. therapeutic efficacy against cardiometabolic impairments its ability restore homeostatic pathways.

Language: Английский

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Investigation of the effect of Cadmium chloride applied during pregnancy on the morphological parameters of mouse offspring and the protective role of melatonin

Journal of Hazardous Materials Advances, Journal Year: 2022, Volume and Issue: 9, P. 100222 - 100222

Published: Dec. 23, 2022

Heavy metals are the main risk factor for impaired fetal development. Cadmium accumulated in tissues can restrict growth and Melatonin is an antioxidant has a therapeutic effect. The aim of this study to determine effects exposure Chloride during pregnancy mice on birth weight pups, number morphological parameters pups investigate protective role melatonin against these effects. Seven groups (n:6) were created with Swiss Albino mice. chloride administered i.p. orally. weighed day they born. Tail length, length between two temporal regions, femur crown rump measured. Different variables compared among by analysis variance followed Duncan's test, differences considered statistically significant when p < 0.05. lowest body was found group that given orally (p 0.05). increased mean tail, inter temporal, femoral values decreased where route, but it highest orally, value route. premature birth, led decrease caused change Orally had positive effect reproduction, prevented Chloride-induced loss increase length. We opinion additional long-term studies subject needed.

Language: Английский

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