Midwifery, Journal Year: 2025, Volume and Issue: unknown, P. 104384 - 104384
Published: March 1, 2025
Language: Английский
The Lancet Diabetes & Endocrinology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
83
Osteoarthritis and Cartilage, Journal Year: 2024, Volume and Issue: 32(4), P. 452 - 459
Published: Feb. 12, 2024
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, predominant use of body mass index (BMI) to define obesity in OA research associated with uncertainties and limitations. These include inability discern fat muscle mass, account sex-differences distribution, or identify adiposityrelated health impairments. A focus on BMI may influence weight bias clinical practice impact disparities access effective treatments. To ensure that our understanding approaches improve outcomes individuals at risk continues advance next decade, future will need consider alternative measures beyond identification align evolving science. researchers must be aware issues stigma work minimize negative generalizations based BMI.
Language: Английский
Citations
20
Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)
Published: March 19, 2024
Abstract The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions exchange recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT STEP-HFpEF) bempedoic acid (CLEAR Outcomes), the advances they represent in reducing risk of major adverse cardiovascular events (MACE), improving metabolic outcomes, treating obesity-related heart failure with preserved ejection fraction (HFpEF). A broad audience endocrinologists, diabetologists, cardiologists, nephrologists primary care physicians participated online guideline updates management disease (CVD) diabetes, (HF) chronic kidney (CKD); type 1 diabetes (T1D) its comorbidities; CKD SGLT2 inhibitors non-steroidal mineralocorticoid receptor antagonists (nsMRAs); treatment obesity GLP-1 dual GIP/GLP-1 agonists. association nonalcoholic steatohepatitis (NASH; dysfunction-associated steatohepatitis, MASH) cancer possible treatments these complications were also explored. It is generally assumed that diseases equally effective all patients. However, discussed at Summit, this assumption may not be true. Therefore, it important to enroll patients from diverse racial ethnic groups clinical analyze patient-reported assess efficacy, develop innovative approaches tailor medications those who benefit most minimal side effects. Other keys successful comorbidities, dementia, entail use continuous glucose monitoring (CGM) technology implementation appropriate patient-physician communication strategies. 10th Summit will December 5–6, 2024 ( http://www.cvot.org ).
Language: Английский
Citations
9
Obesity Science & Practice, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 8, 2025
ABSTRACT Objective Obesity is a disease with severe health impacts on individuals and economic society, yet healthcare practitioners (HCPs) policy makers often fail to address it. This survey was conducted examine current global obesity care perceptions influencing delivery among HCPs decision (HC DMs). Methods A cross‐sectional design 1200 (primary providers, endocrinologists, cardiologists, nurses) 414 HC DMs from eight countries across five continents. Respondents' of obesity, characteristics patient populations, management practices, obesity‐related policies were collected. Surveys administered online June–July 2023. All respondent data anonymized. Results Among HCPs, 26.4% 29.0% considered chronic disease, 44.6% reported that recorded as in patients' medical records. The pattern responses consistent professional roles. approaches focused lifestyle concerns. appeared overestimate the provision for affected patients. Conclusion These results corroborate prior findings many do not consider which hinders initiation appropriate treatment, also highlight challenges management, including gaps guidelines accessibility healthcare. may help guide education outreach by authorities well HCPs.
Language: Английский
Citations
1
JMIR Pediatrics and Parenting, Journal Year: 2025, Volume and Issue: 8, P. e67213 - e67213
Published: Jan. 24, 2025
Abstract Background Obesity rates among Saudi adolescents are increasing, with regional variations highlighting the need for tailored interventions. School-based health programs in Arabia limited and often emphasize weight body size, potentially exacerbating image dissatisfaction. There is knowledge on feasibility of non–weight-centric educational their effects behaviors image. Objectives This study aimed to (1) assess prevalence obesity using BMI-for-age z score (BAZ) fat percentage adolescents; (2) evaluate key behaviors, cardiovascular fitness, literacy; (3) impact a low-intensity, intervention designed improve macronutrients metabolic diseases, while examining its safety discrepancies. Methods A quasi-experimental, pre-post trial parallel, nonequivalent control group design was conducted 95 (58 boys 37 girls; mean age 16.18, SD 0.53 years) from 2 public high schools Medina City, Arabia. Participants were randomly assigned either weight-neutral Macronutrient + Non-Communicable Diseases Health Education or group. Anthropometry (BAZ percentage), physical activity, eating measured at baseline. Independent t tests χ ² compare differences, 2-way mixed ANOVA used effect macronutrient total 69 participants completed postintervention assessments. Results The overweight based BAZ 37.9% (36/95), 50.5% (48/95) classified as overfat obese percentage. Students normal status significantly more likely have had prior exposure education related diseases than students higher ( P =.02). improved macronutrient-metabolic F 1,64 =23.452; <.001), large size (partial η²=0.268). no significant change students’ pre- =.70), supporting these programs. demonstrated strong feasibility, recruitment rate 82.6% retention 72.6%. Conclusions reveals adolescents, particularly when improvement nonimpact suggest that can foster better outcomes without Region-specific strategies prioritize over weight-centric messaging should be considered address both concerns adolescents.
Language: Английский
Citations
1
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 10, 2025
Obesity, a surging global health challenge, necessitates effective, accessible and innovative therapeutic models. Here we develop spatiotemporally controllable microneedle (MN) drug delivery platform for sono-gene therapy to fight obesity. The delivers the methoxy polyethylene glycol-polyethyleneimine (mPEG-PEI) modified metal-organic frameworks (MOFs) sonosensitizer clustered regularly interspaced short palindromic repeats-activating (CRISPRa)/CRISPRa-uncoupling protein 1 (UCP1) system intradermally adipocytes. Overall, this is capable of achieving two major strategies "annihilation" "countermeasure": one kill redundant white adipocytes by sonodynamic therapy, other promote browning through release CRISPRa-UCP1 effect. Obese male mice treated with shows significant ameliorate in glucose tolerance insulin sensitivity, successfully achieves weight loss restrains rebound. This study may enable standard treatment paradigm obesity metabolic diseases. needs effective Here, authors show loaded
Language: Английский
Citations
1
Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Language: Английский
Citations
6
Obesity Facts, Journal Year: 2024, Volume and Issue: 17(3), P. 217 - 226
Published: Jan. 1, 2024
Being stigmatized because of one's weight can pose physical, mental, and social challenges. While stigma its consequences are established throughout Europe, North America, Australasia, less is known about in other regions. The objective this study was to identify the extent focus research Latin Asia, Middle East, Africa.
Language: Английский
Citations
5
Journal of Midwifery & Women s Health, Journal Year: 2024, Volume and Issue: 69(3), P. 333 - 341
Published: March 9, 2024
Introduction Weight bias toward individuals with higher body weights permeates health care settings in the United States and has been associated poor weight‐related communication quality of as well adverse outcomes. However, there limited quantitative investigation into weight among perinatal providers. Certified nurse‐midwives (CNMs)/certified midwives (CMs) attend approximately 11% all births States. The aims this study were to measure direction extent CNMs/CMs compare their levels US public other professionals. Methods Through direct postcard distribution, social media accounts, professional networks, email listservs, American Midwifery Certification Board (AMCB)‐certified solicited complete an online survey implicit using Implicit Association Test explicit Antifat Attitudes Questionnaire, Fat Phobia Scale, Preference for Thin People measure. Results A total 2257 participated survey, yielding a completion rate 17.7%. Participants mostly White female, median age 46 years 11 since AMCB certification. More than 70% have some level bias, although lesser compared previously published findings ( P < .01) professionals .01). In subsample comparison female physicians, similar > .05). Midwives also express but at lower Discussion This provides first research documenting national sample Findings can inform educational efforts mitigate setting decrease harm.
Language: Английский
Citations
5
Eating Disorders, Journal Year: 2024, Volume and Issue: 32(6), P. 746 - 762
Published: Aug. 22, 2024
Epidemiologic research has identified numerous interpersonal and individual risk factors for warning signs of emerging eating disorders in adolescents. These findings have informed public health prevention treatment strategies, including translation to clinical recommendations primary care providers (PCPs). A next step this translational work could include a comprehensive approach where PCPs are seen as partners efforts improve population outcomes. great potential implement high-yield interventions that prevent or attenuate the course adolescent disorders. To illustrate potential, we present case highlights missed opportunities PCP prevent, detect, intervene during patient's developing disorder. We then relate two programs utilize partnerships: one trains Strengths-Based Adolescent Healthcare disorder prevention; other adapts Family-Based Treatment early access evidence-based treatment. In addition these promising areas research, needed widen requirements curricula medical training address weight stigma care. Together will help become effective
Language: Английский
Citations
5