Prenatal polycyclic aromatic hydrocarbons exposure and child growth and adiposity: A longitudinal study
Environmental Research,
Journal Year:
2025,
Volume and Issue:
268, P. 120756 - 120756
Published: Jan. 4, 2025
Language: Английский
Subtypes of Gestational Diabetes Mellitus Are Differentially Associated With Newborn and Childhood Metabolic Outcomes
Meredith Osmulski,
No information about this author
Yuanzhi Yu,
No information about this author
Alan Kuang
No information about this author
et al.
Diabetes Care,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
OBJECTIVE
Subtypes
of
gestational
diabetes
mellitus
(GDM)
based
on
insulin
sensitivity
and
secretion
have
been
described.
We
addressed
the
hypothesis
that
GDM
subtypes
are
differentially
associated
with
newborn
child
anthropometric
glycemic
outcomes.
RESEARCH
DESIGN
AND
METHODS
Newborn
(age
11–14
years)
outcomes
were
examined
in
7,970
4,160
mother-offspring
dyads,
respectively,
who
participated
Hyperglycemia
Adverse
Pregnancy
Outcome
Study
(HAPO)
Follow-Up
Study.
was
classified
as
insulin-deficient
(insulin
<25th
percentile
preserved
sensitivity),
insulin-resistant
secretion),
or
mixed-defect
(both
percentile).
Regression
models
for
included
adjustment
field
center,
maternal
BMI,
other
pregnancy
covariates.
Child
also
age,
sex,
family
history
diabetes.
RESULTS
Compared
mothers
normal
glucose
tolerance,
all
three
birth
weight
sum
skinfolds
>90th
percentile.
Insulin-resistant
higher
risk
cord
C-peptide
levels
neonatal
hypoglycemia.
hypoglycemia
childhood
obesity
(odds
ratio
[OR]
1.53,
95%
CI
1.127–2.08).
The
child-impaired
tolerance
(OR
2.21,
1.50–3.25)
3.01,
1.47–6.19).
CONCLUSIONS
Better
characterizing
individuals
could
help
identify
at-risk
offspring
to
offer
targeted,
preventative
interventions
early
life.
Language: Английский
Multisystem Interconnected Lifestyle Framework: A Holistic Approach to Examining the Lifestyle Determinants of Obesity in Early Childhood
Journal of Nutrition Education and Behavior,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
report
proposes
the
multisystem
interconnected
lifestyle
(MIL)
framework
to
describe
how
behaviors
(i.e.,
sleep,
stress,
activity,
diet)
work
together
create
profiles
of
young
children's
obesogenic
risk.
argues
that
considering
collectively
within
and
across
days
more
accurately
captures
complexity
obesity
The
MIL
builds
on
social
ecological
models
situate
behavior
connections
contexts
lives.
potentiates
next
generation
research,
reflecting
a
holistic
understanding
engagement
could
inform
effective
targeted
education
intervention
approaches.
Language: Английский
A Callout for Obesity Prevention Trials in Early Childhood
Richard E. Boles,
No information about this author
Ihuoma Eneli
No information about this author
PEDIATRICS,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Rapid
weight
gain
in
infancy
and
early
childhood
are
risk
factors
for
obesity
subsequent
years.1
There
several
reasons
this
pattern
of
gain,
some
occurring
before
during
the
pregnancy
(eg,
high
pre-pregnancy
[body
mass
index
>30],
excessive
gestational
diabetes,
epigenetic
programming
fetus
pregnancy),
others
feeding
behaviors
that
neglect
infant
hunger
satiety
cues,
social
environmental
such
as
low
socioeconomic
status
adiposity
rebound).1
This
has
led
to
a
call
maternal
child
interventions
from
prenatal
period
(first
1000
days)
prevent
obesity.
Several
randomized
controlled
trials
have
demonstrated
critical
can
excess
birth
preschool,
with
short-term
success
(ie,
generally
less
than
3
years),
although
reports
longer-term
outcomes
by
preschool
age
limited.2–4The
study
Kim
et
al
issue
Pediatrics
examines
whether
positive
effects
Starting
Early
Program
(StEP),
an
prevention
program
delivered
within
primary
care
setting
third
trimester
until
was
33
months,
on
trajectory
prevalence
2
years
sustained
into
years.5
The
also
sought
investigate
prior
findings
StEP
trial—the
effect
support/drivers
health
assessed
at
baseline
dose
intervention
child's
weight—endured
ages
4
5
years.Their
were
consistent
most
childhood,
treatment
preventing
but
not
sustained.4
However,
adjusted
logistic
regression
analysis,
participants
group
higher
attendance
(11–15
sessions)
vs
lower
(0–10
had
statistically
significant
or
age,
encouraging
signal.5Since
United
States
Preventive
Services
Task
Force
recommendation
26
contact
hours
over
6
12
months
necessary
lifestyle
older
children
(≥
years)
clinically
reduction
weight,6
there
been
considerable
debate
field
about
practicality
meeting
practice,
cadence
manner
(in
person,
telehealth,
telephone)
which
should
be
delivered,
variability
response
depending
characteristics
population
white
minoritized
populations
status).
Compared
much
amount
recommended
(≥26
hours)
changes
among
who
already
obesity,
possibility
families
attend
fewer
sessions
is
particularly
appealing.
Heerman
al,
comparable
low-income
Hispanic
mothers
young
children,
found
mode
delivery
does
all
need
occur
face-to-face
visits,
easing
burden
participation
families.7
We
more
studies
affirm
right
intensity
prevention,
determine
delivery,
identify
key
targets
bolster
durability
programs
children.In
examining
their
secondary
outcomes,
only
support
defined
"the
number
people
participant
turn
to"
moderator.
Interestingly,
analysis
yielded
diametrically
opposed
control
group.
average
weight-for-age
z-scores
(WFAz)
reported
(≥2
people)
pregnancy,
whereas
WFAz
scores
(<2
people).
In
case,
construct
relation
unclear.
For
instance,
what
seeking
when
turning
others?
And
how
relate
developing
childhood?
Other
drivers
(SDoH)—marital
status,
food
insecurity,
housing,
financial
challenges—were
significant,
though
power
may
reduced
given
dichotomous
nature
these
variables.
Composite
combine
each
variables
create
sensitive
continuous
variable,
psychometric
evaluations
required
validate
approach.The
loss
follow-up
(∼42%)
occurred
subgroups
raising
concerns
attrition
bias.
interpretation
would
strengthened
describing
differences
interest
confounders,
dose,
race/ethnicity,
birthweight
between
retained
lost
4-
5-year
visits).
These
data
points
collected
visit
available
participants.
Also,
height
measures
obtained
trained
staff
use
outcome
instead
body
index,
commonly
used
measure,
confusing.
limitation
potentially
inaccurate
similarly
applicable
assessing
prevalence,
since
based
index.Even
limitations
hinder
relevance
study,
strengths.
very
intensive
embedded
settings,
helpful
scalability
our
ability
reach
families.
SDoH
moderate
growth
provide
additional
study.
Finally,
considering
recent
attention
treating
around
medications
like
glucagon-like
peptide-1,
once
again
reminds
us
importance
part
armamentarium
tackling
pediatric
Language: Английский
Transgender healthcare: metabolic outcomes and cardiovascular risk
Diabetologia,
Journal Year:
2024,
Volume and Issue:
67(11), P. 2393 - 2403
Published: July 3, 2024
Language: Английский
Secular trends in frailty among community-dwelling 75–95-year-old cohorts over three decades in Helsinki, Finland
Age and Ageing,
Journal Year:
2024,
Volume and Issue:
53(8)
Published: Aug. 1, 2024
Abstract
Background
Frailty
Index
(FI)
reflects
health,
functioning
and
well-being
of
older
people.
It
is
valuable
to
compare
how
frailty
has
changed
over
time
in
ageing
cohorts.
This
study
aims
examine
trends
among
75–95-year-old
men
women
three
decades.
Methods
The
Helsinki
Ageing
Study
started
1989
includes
repeated
cross-sectional
postal
surveys
every
10
years
examining
community-dwelling
cohorts
people
(75,
80,
85,
90
95
years).
FI
comprises
the
same
36
items
each
cohort.
Results
mean
was
0.22
(SD
0.12),
0.25
0.15),
0.26
0.15)
0.23
1989,
1999,
2009
2019,
respectively
(P
for
linearity
crude
values
.11).
Adjusted
age
sex,
four
differed
their
2019
cohort
having
lowest
FI.
sex-adjusted
difference
seen
75-,
80-,
85-
90-year-olds
but
not
95-year-olds.
decreased
more
than
<.001,
P
sex
<.01,
interaction
=
.19).
Conclusions
prevalence
individuals
aged
75,
85
years—but
those
years—has
significantly
last
positive
trend
may
have
important
implications
health
policies
societies
with
increasing
longevity.
Language: Английский
A randomized controlled trial to test the efficacy of a brief Triple P discussion group to increase healthy feeding practices and reduce risk factors for infant obesity
Journal of Pediatric Psychology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Objective
Test
the
efficacy
of
a
brief
2-hr
parenting
intervention
in
increasing
protective
factors
against
and
reducing
risk
for
infant
obesity.
Method
A
2
(Baby
Healthy
Living
Triple
P
vs.
care-as-usual)
×
3
(baseline,
postintervention,
6-month
follow-up)
design
was
used.
Eighty-two
parents
4-
to
18-month-old
infants
meeting
at
least
two
early
childhood
obesity
(e.g.,
parent/child
overweight,
low
education
level)
were
randomized
(n
=
42)
or
control
group
40).
Parents
questionnaires
child
weight
status
measured.
Results
showed
an
effect
on
primary
outcome,
feeding
practices
(restrictive:
d
0.44,
95%
CI
[−0.01,0.88],
pressuring:
0.11,
[−0.32,0.54],
nonresponsive
behaviors:
(d
0.32,
[−0.11,0.75]),
secondary
beliefs
0.29,
[−0.14,0.73]).
No
beneficial
impact
found
other
outcomes
(responsiveness
feeding:
quantity
0.50,
[−0.03,1.03])
nutritive
0.52,
[−0.03,1.07],
mealtime
environment:
0.35,
[−0.78,0.08],
self-efficacy
responsive
0.21,
[−0.22,0.64]),
(parental
self-efficacy:
0.08,
[−0.50,0.35]),
parent
emotional
eating
0.01,
[−0.43,0.43]),
food
restraint
0.42,
[−0.85,0.02]),
body
satisfaction
[−0.43,0.43])
[−0.54,0.32]).
Conclusions
Promising
though
limited
support
demonstrated
brief,
low-intensity
program
help
prevention
risk.
Language: Английский