Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Obesity is a heritable disease, but its genetic basis incompletely understood. Canine population history facilitates trait mapping. We performed canine genome-wide association study for body condition score, measure of obesity, in 241 Labrador retrievers. Using cross-species approach, we showed obesity genes are also associated with rare and common forms humans. The lead was within the gene DENN domain containing 1B (DENND1B). Each copy alternate allele ~7% greater fat. demonstrate role this regulating signaling trafficking melanocortin 4 receptor, critical controller energy homeostasis. Thus, genetics identified mechanisms relevant to both dogs

Language: Английский