Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase DOI Creative Commons
Yutong Liu, Loren Skudder‐Hill, Wandia Kimita

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Aims To investigate the associations of intra‐pancreatic fat deposition (IPFD) with very‐low‐density lipoprotein (VLDL), intermediate‐density (IDL) and lipase. Materials methods A total 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for quantification IPFD. Blood samples were collected following an 8‐h fasting period. Triglyceride‐rich lipoproteins measured using Lipoprint® system classed as VLDL, IDL‐C, IDL‐B IDL‐A subfractions. Lipoprotein lipase was ELISA. Univariable multivariable linear regression analyses conducted. Results Both IPFD significantly associated levels in most adjusted model. Specifically, each unit increase 0.12‐unit ( p = 0.047) whereas 0.22‐unit 0.015). Neither nor VLDL. Conclusions The relationship triglyceride‐rich differs depending nature lipoproteins. High is increased IDL (specifically, its representative subfraction—IDL‐B), but not Fatty pancreas disease may contribute to increasing risk atherosclerotic CVD through IDL.

Language: Английский

Associations of intra‐pancreatic fat deposition with triglyceride‐rich lipoproteins and lipoprotein lipase DOI Creative Commons
Yutong Liu, Loren Skudder‐Hill, Wandia Kimita

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Abstract Aims To investigate the associations of intra‐pancreatic fat deposition (IPFD) with very‐low‐density lipoprotein (VLDL), intermediate‐density (IDL) and lipase. Materials methods A total 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for quantification IPFD. Blood samples were collected following an 8‐h fasting period. Triglyceride‐rich lipoproteins measured using Lipoprint® system classed as VLDL, IDL‐C, IDL‐B IDL‐A subfractions. Lipoprotein lipase was ELISA. Univariable multivariable linear regression analyses conducted. Results Both IPFD significantly associated levels in most adjusted model. Specifically, each unit increase 0.12‐unit ( p = 0.047) whereas 0.22‐unit 0.015). Neither nor VLDL. Conclusions The relationship triglyceride‐rich differs depending nature lipoproteins. High is increased IDL (specifically, its representative subfraction—IDL‐B), but not Fatty pancreas disease may contribute to increasing risk atherosclerotic CVD through IDL.

Language: Английский

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