Association Between Recurrent Aphthous Ulcers and Oral Biodiversity: A Systematic Review and Meta‐Analysis

Journal of Evidence-Based Medicine, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 19, 2025

ABSTRACT Objective This study aimed to investigate the relationship between recurrent aphthous ulcers (RAU) and dysbiosis of oral microbiota. Methods A systematic search was conducted across several databases, including Cochrane Library, PubMed, Web Science Core Collection, Embase, Scopus, CBM, CNKI, WanFang, VIP, identify relevant studies from inception library until September 20, 2024. All included were evaluated for quality using Newcastle–Ottawa scale. These assessed diversity abundance microorganisms in patients with RAU comparison healthy individuals. Results synthesized via random‐effects meta‐analysis ( I 2 statistic heterogeneity). Mean differences (MD) 95% confidence intervals (CI) applied evaluate pooled effects outcomes. The review registered PROSPERO (CRD42024615516). total 10 involving 343 348 controls this study, 7 these utilized conduct a quantitative assessment. showed that terms alpha diversity, saliva samples collected exhibited significantly lower Chao 1 index (MD = –41.22, CI –64.34 –18.09, p < 0.01), ulcerated sites mucosa demonstrated higher when compared within 27.48, 2.98 51.97, 0.03). Conclusions Significant controls, along variations beta relative taxa, indicate microbial may play crucial role development RAU.

Language: Английский

The relationship between smoking and recurrent aphthous stomatitis: A Mendelian randomization study

Tobacco Induced Diseases, Journal Year: 2025, Volume and Issue: 23(January), P. 1 - 10

Published: Jan. 15, 2025

INTRODUCTION Existing research suggests an association between smoking and the incidence of recurrent aphthous stomatitis (RAS); however, causal relationship remains ambiguous.We employed Mendelian randomization (MR) to clarify potential risk developing RAS.METHODS We utilized genome-wide study (GWAS) sequencing data related from Finnish database as instrumental variables (IVs) GWAS for RAS UK Biobank (UKB) outcome perform a two-sample MR analysis.The selection IVs was rigorously controlled according three principal assumptions relevance, independence, exclusivity.The primary analytical methods were inverse variance weighting (IVW) weighted median (WM), supplemented by MR-Egger, simple mode, mode techniques infer causality RAS.Sensitivity analyses conducted using MR-PRESSO, Cochran's Q, MR-Egger intercept ensure robustness findings.RESULTS The findings IVW WM suggest elevated (IVW: OR=1.003; 95% CI: 1.0002-1.005,p=0.033;WM: 1.00006-1.007,p=0.044).Compared non-smokers, smokers have 0.3% increase in RAS.Furthermore, sensitivity analysis did not reveal any inconsistencies that would contradict results.CONCLUSIONS Our provide preliminary evidence RAS, which may contribute deeper understanding underlying mechanisms.Further is needed confirm these results explore their implications clinical practice.

Language: Английский

Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 3, 2024

Background Burning mouth syndrome (BMS) is a chronic idiopathic facial pain with intraoral burning or dysesthesia. BMS patients regularly suffer from anxiety/depression, and the association of psychiatric symptoms has received considerable attention in recent years. The aims this study were to investigate potential interplay between BMS.

Language: Английский