Intra-tumoral bacteria in breast cancer and intervention strategies

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115516 - 115516

Published: Jan. 1, 2025

Language: Английский

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Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 9, 2025

Breast cancer (BC) is one of the leading causes death and morbidity among women worldwide. Epidemiologic evidence shows that risk BC other chronic diseases decreases as proportion whole plant foods increases, while animal (fish, meat, poultry, eggs, seafood, dairy products) non–whole (e.g., refined grains, added sugars, French fries) in diet decreases. Whole include fruits, vegetables, roots, tubers, legumes, nuts, seeds from which no edible part has been removed to food added. A lowers insulin resistance, inflammation, excess body fat, cholesterol, insulin-like growth factor 1 sex hormone bioavailability; it also increases estrogen excretion, induces favorable changes gut microbiota, may favorably affect mammary microbiota composition decrease early menarche, all contributing reduced incidence, recurrence, mortality. This review explores connection between a mortality well potential mechanisms involved. Additionally, this compared with dietary approaches recommended for BC. seems optimal pattern overall disease prevention exclusively consists which, based on existing evidence, lead best health outcomes.

Language: Английский

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Oral microbiota: the overlooked catalyst in cancer initiation and progression

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 13, 2025

The advancement of high-throughput sequencing technology in recent decades has led to a greater understanding the components oral microbiota, providing solid foundation for extensive research this field. microbiota plays an important role individual’s overall health. It been shown be significantly correlated with chronic human diseases, including diabetes, rheumatoid arthritis, cardiovascular disease, periodontal and Alzheimer’s disease. Furthermore, tumor occurrence development are closely related microbiome. Specific bacteria, such as Fusobacterium nucleatum ( F. ), Porphyromonas gingivalis P. Streptococcus , Streptomyces Prevotella Fibrophagy gingivalis, play critical roles cancer development. various oncogenic mechanisms, bacterial inflammation, immunological suppression, growth mediated by toxins, antiapoptotic activity, carcinogenic effects. This paper reviews progression systematically elucidates molecular mechanisms which dysbiosis influences tumorigenesis progression. information can provide theoretical basis exploring treatment strategies offer new insights prevention.

Language: Английский

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Interactions between the tumor microbiota and breast cancer

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 24, 2025

Breast cancer is the most common malignancy in women worldwide. Changes microbiota and their metabolites affect occurrence development of breast cancer; however, specific mechanisms are not clear. Gut microbes influence by regulating tumor immune response, estrogen metabolism, chemotherapy, immunotherapy effects. It was previously thought that there were no microorganisms tissue, but it now can outcome disease. This review builds on existing research to comprehensively analyze role gut intratumoral metastasis cancer. We also explore potential function as biomarkers for prognosis therapeutic highlighting need further clarify causal relationship between hope provide new ideas directions methods treatment.

Language: Английский

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Fusobacterium nucleatum elicits subspecies-specific responses in human neutrophils

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 10, 2024

as a Gram-negative anaerobe plays key bridging role in oral biofilms. It is involved periodontal and extraoral diseases, the most prominent being colorectal cancer. Five subspecies are recognised:

Language: Английский

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