Post-stroke osteoporosis: Mechanisms, treatments, and recent advances DOI
Zongbing Liu, Xiaoguang Liu, Congcong Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 59 - 67

Published: Sept. 1, 2024

Post-stroke osteoporosis (PSO) is a common complication encountered in patients after stroke, characterized by rapid decline bone mass and disruption of microarchitecture, which significantly elevates the risk fracture. The pathogenesis PSO multifaceted, encompassing factors, such as oxidative stress, inflammatory responses, neurological damage, extended immobilization, hormonal imbalances, culminating dysregulation metabolism. Treatment strategies encompass pharmacological interventions, nutritional supplementation, physical exercise, rehabilitative training. Emerging therapies, stem cell therapy exosome therapy, are being explored for their potential to promote cellular regeneration modulate responses treatment PSO. Future therapeutic approaches should integrate comprehensive understanding multifactorial develop tailored plans, aiming optimize efficacy improve patients’ quality life.

Language: Английский

Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis DOI Creative Commons

Yinuo Fan,

Zhiwen Chen, Haixing Wang

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 26, 2025

Abstract The death of osteoblasts induced by glucocorticoid (GC)-mediated oxidative stress plays a crucial role in the development steroid-induced osteonecrosis femoral head (SIONFH). Improving bone formation driven has shown promising outcomes prognosis SIONFH. Isovitexin demonstrated antioxidant properties, but its therapeutic effects on GC-induced and SIONFH remain unexplored. In this study, we analyzed clinical samples obtained from patients using proteomic bioinformatic approaches. We found an imbalance mitochondrial homeostasis ferroptosis-induced impairment osteogenic capacity Subsequently, investigated cause-and-effect relationship between mitochondria ferroptosis, as well regulatory mitophagy maintaining controlling ferroptosis. then identified critical involvement SIRT3 modulating Furthermore, molecular docking co-immunoprecipitation confirmed strong interaction BNIP3. Strikingly, restoring expression significantly inhibited pathological mediated BNIP3/NIX pathway. Additionally, discovered that Isovitexin, promoting expression, effectively regulated mitophagy, preserved osteoblasts, suppressed restored capacity, leading to remarkable improvements These findings reveal mechanisms highlight potential targeting strategy suppress mitophagy-mediated ferroptosis against

Language: Английский

Citations

1
Analysis of Animal Models of Traumatic Osteonecrosis of the Femoral Head Based on Blood Supply: A Literature Review DOI Creative Commons

Linbao Wang,

Yuhao Luo, Xing Qiu

et al.

Orthopaedic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

ABSTRACT Traumatic osteonecrosis of the femoral head (TONFH) refers to ischemic is resulting from an acute mechanical interruption blood supply head. The early diagnosis and optimal treatment have been central focuses research continue undergo improvement. Reliable animal models are essential for advancing into disease. This review aims provide a comprehensive overview tetrapod (rats, rabbits, dogs, sheep) bipod (emus, ostriches), as well various modeling methods (traumatic hip dislocation, dissection round ligament ligature neck, neck fracture (FNF), reduction internal fixation after fracture, highly selective disruption anterior‐superior retinacular vessels). examines advantages, disadvantages, applicability each model. Based on flow analysis, it proposes more reliable direction TONFH modeling: simulating partial injury in context FNF.

Language: Английский

Citations

0
Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine DOI
Qin Jian,

Ziyi Luo,

Xu Yang

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106687 - 106687

Published: Jan. 23, 2025

Language: Английский

Citations

0
Identification and validation of endoplasmic reticulum stress-related genes in patients with steroid-induced osteonecrosis of the femoral head DOI Creative Commons
Tingyu Wu, Weipeng Shi,

Yinxue Zhou

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 16, 2024

Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating condition caused by long-term corticosteroid use, leading to impaired blood flow and bone cell death. The disruption cellular processes promotion apoptosis endoplasmic reticulum stress (ERS) implicated in pathogenesis SONFH. We identified ERS-associated genes SONFH investigated their potential as therapeutic targets. analysed GSE123568 GEO dataset identify differentially expressed (DEGs) related ERS conducted Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses, hub protein-protein interaction (PPI) evaluated functions gene set analysis (GSEA). constructed mRNA-miRNA networks, therapeutics, assessed immune infiltration. performed cross-validation using GSE74089, qRT-PCR on clinical samples from patients with controls, receiver operating characteristic (ROC) curve assess diagnostic performance genes. 195 ERS-related SONFH, which were primarily involved oxidative stress, responses, metabolic pathways. PPI network suggested CXCL8, STAT3, IL1B, TLR4, PTGS2, TLR2, CASP1, CYBB, CAT, HOMX1 be key genes, shown GSEA biological pathways metabolism, modulation, integrity. also 261 microRNAs (miRNAs) well drugs such dibenziodolium N-acetyl-L-cysteine that modulated inflammatory responses Twenty-two subtypes showed significant correlations, positive correlation between activated mast cells Tregs, had fewer dendritic than controls. CYBB TLR4 correlations M1 macrophages CD8 T cells, respectively. Cross-validation confirmed upregulation CASP1 validating bioinformatics findings. An ROC top 10 show promise biomarkers for discovered miRNAs, including hsa-miR-23, influence these therapeutics simvastatin. Immune profiling indicated altered among types. Validation TLR2 potential. findings suggest markers targets

Language: Английский

Citations

3
Paeonol regulates autophagy through the PI3K-AKT-mTOR signaling pathway to inhibit apoptosis of osteocytes DOI
Shuwei Gong,

Aixian Tian,

Silvia Lang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177427 - 177427

Published: Feb. 1, 2025

Language: Английский

Citations

0
Traditional Chinese medicine Youguiyin decoction ameliorate glucocorticoid-induced osteonecrosis in rat by modulating ROS/PHD2/HIF-1α oxidative stress signaling pathway in bone marrow mesenchymal stem cells DOI Creative Commons
Hongzhong Xi, Hao Chen,

Jiahao Fu

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 3, 2025

Abstract Background The incidence of osteonecrosis is increasing annually due to the widespread use glucocorticoids. Recent evidence suggests a significant association between glucocorticoid-induced and oxidative stress. Youguiyin (YGY) decoction, classic formula traditional Chinese medicine, has been widely used for prevention osteonecrosis. However, its underlying pharmacological mechanisms are still not fully understood. Methods UPLC-Q-TOF–MS network pharmacology were elucidate material basis YGY decoction mechanism treatment anti-oxidative stress bone-enhancing effects in vivo detected by hematoxylin–eosin (HE) staining, serum metabolomics, enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), Western Blot (WB). Rat bone marrow mesenchymal stem cells (BMSCs) induced with dexamethasone (DXMS) 24 h, followed medicated h. Significantly up- down-regulated genes RNA sequencing. Oxidative levels ROS fluorescence. Alizarin red S staining was detect osteogenic effects. WB ELISA expression proteins related ROS/PHD2/HIF-1a pathway. Results application significantly promoted repair antagonized excess reactive oxygen species (ROS) generation glucocorticoid-associated femoral head (GA-ONFH) rats. In addition, DXMS-induced production differentiation BMSCs. We also found that attenuated while PHD2 increased, HIF-1α decreased RUNX2 increased. Conclusion These results provide compelling vitro may play role promoting targeting mediation ROS/PHD2/HIF-1α signaling pathway, thus providing new theoretical clinical Graphical

Language: Английский

Citations

0
Glucose-Dependent Insulinotropic Polypeptide Inhibits AGE-Induced NADPH Oxidase-Derived Oxidative Stress Generation and Foam Cell Formation in Macrophages Partly via AMPK Activation DOI Open Access
Michishige Terasaki, Hironori Yashima, Yusaku Mori

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9724 - 9724

Published: Sept. 8, 2024

Glucose-dependent insulinotropic polypeptide (GIP) of the incretin group has been shown to exert pleiotropic actions. There is growing evidence that advanced glycation end products (AGEs), senescent macromolecules formed at an accelerated rate under chronic hyperglycemic conditions, play a role in pathogenesis atherosclerotic cardiovascular disease diabetes. However, whether and how GIP could inhibit AGE-induced foam cell formation macrophages, initial step atherosclerosis remains be elucidated. In this study, we address these issues. We found AGEs increased oxidized low-density-lipoprotein uptake into reactive oxygen species (ROS) generation

Language: Английский

Citations

2
Post-stroke osteoporosis: Mechanisms, treatments, and recent advances DOI
Zongbing Liu, Xiaoguang Liu, Congcong Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 59 - 67

Published: Sept. 1, 2024

Post-stroke osteoporosis (PSO) is a common complication encountered in patients after stroke, characterized by rapid decline bone mass and disruption of microarchitecture, which significantly elevates the risk fracture. The pathogenesis PSO multifaceted, encompassing factors, such as oxidative stress, inflammatory responses, neurological damage, extended immobilization, hormonal imbalances, culminating dysregulation metabolism. Treatment strategies encompass pharmacological interventions, nutritional supplementation, physical exercise, rehabilitative training. Emerging therapies, stem cell therapy exosome therapy, are being explored for their potential to promote cellular regeneration modulate responses treatment PSO. Future therapeutic approaches should integrate comprehensive understanding multifactorial develop tailored plans, aiming optimize efficacy improve patients’ quality life.

Language: Английский

Citations

0