Emerging Treatment Options for Peanut Allergy

Allergies, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5

Published: Feb. 19, 2025

Peanut allergy, a significant public health issue, poses challenges due to its potential for life-threatening anaphylaxis and profound impact on quality of life. Traditional management approaches, including allergen avoidance epinephrine administration, are effective in mitigating acute symptoms but do not address the underlying allergy or long-term disease burden. Recent advances immunotherapy biologics, as well innovative technologies such gene editing microbiome modulation, have introduced promising pathways desensitization sustained unresponsiveness. This review provides comprehensive exploration emerging therapies peanut oral, sublingual, epicutaneous immunotherapy, biologic agents, gene-editing techniques, novel drug therapies. We discuss their mechanisms, clinical efficacy, associated challenges, emphasizing these innovations revolutionize treatment. Despite progress, barriers adverse reactions, cost, limited access remain. Addressing through further research standardization could transform future management.

Language: Английский

Baked Egg Oral Immunotherapy: Current State in Pediatric Age

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3203 - 3203

Published: Sept. 22, 2024

Hen’s egg allergy is one of the most common food allergies in Western world, with an increase recent years. It affects about 9.5% pediatric population, and onset often occurs before first year life. The occurrence spontaneous oral tolerance acquisition varies among studies, but it generally high by school age. Nowadays, allergen immunotherapy may represent only therapeutic strategy able to modify natural history hen’s allergy. Specifically, many children tolerate baked eggs. Food processing, specifically temperatures, alters allergenicity proteins causing conformational changes epitopes, which makes them less allergenic. This review aims discuss scientific evidence field egg-allergic children, a meticulous examination pertinent literature surrounding subject matter.

Language: Английский