Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5889 - 5889
Published: Aug. 5, 2023
Nanoemulsion
is
a
new
multi-component
drug
delivery
system;
the
selection
of
different
oil
phases
can
give
it
special
physiological
activity,
and
play
role
"medicine
pharmaceutical
excipients
all-in-one".
In
this
paper,
we
used
glycyrrhizic
acid
as
natural
surfactant,
Blumea
balsamifera
(BB)
tea
tree
(TTO)
mixed
phase,
to
obtain
green
functional
composite
nanoemulsion.
Using
average
particle
size
polydispersion
index
(PDI)
evaluation
criteria,
effects
ratio,
content,
concentration,
ultrasonic
time
on
nanoemulsion
were
systematically
investigated.
The
stability
physicochemical
properties
biological
activities
BB-TTO
NEs
prepared
via
optimum
formulation
characterized.
optimal
prescription
was
BB:
TTO
=
1:1,
5%
0.7%
acid,
5
min
ultrasonication
time.
mean
size,
PDI,
zeta
potential
160.01
nm,
0.125,
-50.94
mV,
respectively.
showed
non-significant
changes
in
after
centrifugation,
dilution,
120
days
storage.
These
nanoemulsions
found
exhibit
antibacterial
anti-inflammatory
activities.
minimal
inhibitory
concentration
(MIC)
against
Escherichia
coli,
Staphylococcus
aureus,
Pseudomonas
aeruginosa
2975
μg/mL,
5950
A
lower
level
inflammatory
cell
infiltration
proportion
fibrosis
synovial
tissue
AIA
rats
treated
with
NEs.
findings
demonstrate
that
produced
study
have
significant
for
usage
areas.
Microbiology Spectrum,
Journal Year:
2023,
Volume and Issue:
11(3)
Published: May 18, 2023
Plants
are
no
longer
considered
standalone
entities;
instead,
they
harbor
a
diverse
community
of
plant
growth-promoting
rhizobacteria
(PGPR)
that
aid
them
in
nutrient
acquisition
and
can
also
deliver
resilience.
Host
plants
recognize
PGPR
strain-specific
manner;
therefore,
introducing
untargeted
might
produce
unsatisfactory
crop
yields.
Consequently,
to
develop
microbe-assisted
Hypericum
perforatum
L.
cultivation
technique,
31
were
isolated
from
the
plant's
high-altitude
Indian
western
Himalayan
natural
habitat
vitro
characterized
for
multiple
attributes.
Among
rhizobacterial
isolates,
26
produced
0.59
85.29
μg
mL-1
indole-3-acetic
acid
solubilized
15.77
71.43
inorganic
phosphate;
21
63.12
99.92%
siderophore
units,
15
exhibited
103.60
1,296.42
nmol
α-ketobutyrate
mg-1
protein
h-1
1-aminocyclopropane-1-carboxylate
deaminase
(ACCD)
activity.
Based
on
superior
attributes,
eight
statistically
significant
multifarious
further
evaluated
an
planta
growth-promotion
assay
under
poly
greenhouse
conditions.
treated
with
Kosakonia
cowanii
HypNH10
Rahnella
variigena
HypNH18
showed,
by
amounts,
highest
photosynthetic
pigments
performance,
eventually
leading
biomass
accumulation.
Comparative
genome
analysis
comprehensive
mining
unraveled
their
unique
genetic
features,
such
as
adaptation
host
immune
system
specialized
metabolites.
Moreover,
strains
several
functional
genes
regulating
direct
indirect
mechanisms
through
acquisition,
phytohormone
production,
stress
alleviation.
In
essence,
current
study
endorsed
cogent
candidates
H.
highlighting
exclusive
genomic
signatures,
which
suggest
unison,
compatibility,
multifaceted
beneficial
interactions
support
excellent
performance
observed
trial.
IMPORTANCEHypericum
(St.
John's
wort)
herbal
preparations
among
top-selling
products
treat
depression
worldwide.
A
portion
overall
supply
is
sourced
wild
collection,
prompting
rapid
decline
stands.
Crop
seems
lucrative,
although
cultivable
land
its
existing
rhizomicrobiome
well
suited
traditional
crops,
sudden
introduction
create
soil
microbiome
dysbiosis.
Also,
conventional
domestication
procedures
increased
reliance
agrochemicals
reduce
diversity
associated
plants'
ability
interact
microorganisms,
production
alongside
harmful
environmental
effects.
Cultivating
crop-associated
reconcile
concerns.
combinatorial
vitro,
vivo
silico
prediction
traits,
here
we
recommend
two
perforatum-associated
PGPR,
HypNH18,
extrapolate
bioinoculants
sustainable
cultivation.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5889 - 5889
Published: Aug. 5, 2023
Nanoemulsion
is
a
new
multi-component
drug
delivery
system;
the
selection
of
different
oil
phases
can
give
it
special
physiological
activity,
and
play
role
"medicine
pharmaceutical
excipients
all-in-one".
In
this
paper,
we
used
glycyrrhizic
acid
as
natural
surfactant,
Blumea
balsamifera
(BB)
tea
tree
(TTO)
mixed
phase,
to
obtain
green
functional
composite
nanoemulsion.
Using
average
particle
size
polydispersion
index
(PDI)
evaluation
criteria,
effects
ratio,
content,
concentration,
ultrasonic
time
on
nanoemulsion
were
systematically
investigated.
The
stability
physicochemical
properties
biological
activities
BB-TTO
NEs
prepared
via
optimum
formulation
characterized.
optimal
prescription
was
BB:
TTO
=
1:1,
5%
0.7%
acid,
5
min
ultrasonication
time.
mean
size,
PDI,
zeta
potential
160.01
nm,
0.125,
-50.94
mV,
respectively.
showed
non-significant
changes
in
after
centrifugation,
dilution,
120
days
storage.
These
nanoemulsions
found
exhibit
antibacterial
anti-inflammatory
activities.
minimal
inhibitory
concentration
(MIC)
against
Escherichia
coli,
Staphylococcus
aureus,
Pseudomonas
aeruginosa
2975
μg/mL,
5950
A
lower
level
inflammatory
cell
infiltration
proportion
fibrosis
synovial
tissue
AIA
rats
treated
with
NEs.
findings
demonstrate
that
produced
study
have
significant
for
usage
areas.
