d-Amino acids: new clinical pathways for brain diseases

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(12), P. 1014 - 1028

Published: Sept. 26, 2023

Language: Английский

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Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 85 - 85

Published: Jan. 1, 2025

Antipsychotic medications are a vast class of drugs used for the treatment psychotic disorders such as schizophrenia. Although numerous compounds have been developed since their introduction in 1950s, several patients do not adequately respond to current treatments, or they develop adverse reactions that cause discontinuation. Moreover, past few decades, discoveries pathophysiology opened way experimenting with novel alternative mechanisms action, some them showing promising results early trials. The scope this review was summarize antipsychotics developed, experimental status, and action. In particular, we analyzed main classes investigational antipsychotics, monoamine, glutamate, acetylcholine, cannabinoid receptor modulators, enzyme inhibitors, ion channel mixed modulators. addition, safety profiles effects these were carefully evaluated, considering relevance aspects patients’ drug adherence quality life, especially long-term treatment. Lastly, tried understand which greater potential be approved by principal regulatory agencies next years if could diseases other than disorders.

Language: Английский

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Food additives for the central nervous system, useful or harmful? An evidence-based review

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 8, 2025

Objectives This review examines how food additives impact the central nervous system (CNS) focusing on effects of sugars, artificial sweeteners, colorings, and preservatives.

Language: Английский

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Increase in luteinizing hormone is linked to reduction in depression in patients with dementia: Secondary analysis of a randomized clinical trial of benzoate

Psychiatry and Clinical Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Data S1. Table S1 Geriatric Depression Scale (GDS) score and luteinizing hormone concentration between sodium benzoate placebo groups in 97 patients with dementia. S2A. 35 male S2B. 62 female S3. Generalized linear models to predict change after treatment using (LH) at baseline LH from endpoint among treated patients. S4. 49 dementia the GDS of ≥5. S5A. S5B. Please note: The publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed corresponding author article.

Language: Английский

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Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 275 - 275

Published: March 7, 2025

1) Introduction Cognitive enhancers, also known as nootropics, aim to improve cognitive functions, such memory and attention. Despite their potential benefits, the challenges include scientific validation, ethical considerations, regulatory hurdles. This bibliometric study analyzes literature from Scopus identify key trends, influential authors, research gaps, providing guidance for future research. 2) Methods employs a review methodology gather data database on Neuroaid, analyzing it using Biblioshiny VOSviewer software. The focus was Ginkgo Biloba niche-theme enhancer agent based data, both quantitative qualitative analyses. 3) Results discussion biloba, 'maidenhair tree’ order Ginkgoales, appeared 290 million years ago. Chinese Japanese culture has been cultivated thousands of years. tree is valued its resilience therapeutic properties, often used in traditional medicine respiratory blood circulation issues. 4) Conclusions enhancers aims provide comprehensive systematic existing literature, highlighting gaps. findings this will contribute better understanding current state inform conducted December 2024.

Language: Английский

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Differential relationships of NMDAR hypofunction and oxidative stress with cognitive decline

Psychiatry Research, Journal Year: 2023, Volume and Issue: 326, P. 115288 - 115288

Published: June 10, 2023

Language: Английский

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Differential Impacts of Endogenous Antioxidants on Clinical Symptoms and Cognitive Function in Acute and Chronic Schizophrenia Patients

The International Journal of Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 26(8), P. 576 - 583

Published: July 7, 2023

Impaired antioxidant defense is implicated in the pathophysiology of schizophrenia, and superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) are 3 first-line endogenous antioxidants. Various cognitive functions decline differently during schizophrenia course. The characteristic roles antioxidants clinical profiles acute chronic phases require study.We recruited 311 patients with including 92 acutely exacerbated who had been off antipsychotics for at least 2 weeks 219 stable on medication months. Blood SOD, CAT, GSH levels; symptoms; 9 test scores were measured.Blood CAT levels higher than patients, whereas SOD similar to one another. Higher correlated less positive symptoms, better working memory problem solving phase, negative general psychopathology, global assessment function, function (in speed processing, attention, solving) period. phase memory, verbal learning influenced neither nor manifestations.This study showed that blood affected different domains between stages state, but none. Further studies needed explore underlying mechanisms.

Language: Английский

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Intra-uterus phthalate exposure, ROS formation and altered mitochondrial D-loop methylation pattern at birth as potential triggers and markers of Alzheimer’s disease

Medical Hypotheses, Journal Year: 2024, Volume and Issue: 187, P. 111355 - 111355

Published: April 18, 2024

Language: Английский

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Physical Compatibility of Reduced Glutathione for Injection With 44 Intravenous Drugs During Simulated Y-site Administration

Clinical Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Sex- and dose-dependent catalase increase and its clinical impact in a benzoate dose-finding, randomized, double-blind, placebo-controlled trial for Alzheimer's disease

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 245, P. 173885 - 173885

Published: Oct. 9, 2024

Language: Английский

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