Effects of repetitive transcranial magnetic stimulation on inhibitory control in first-episode schizophrenia: behavioral and neural mechanisms DOI Creative Commons

Sihang Yu,

Shuai Wang, Hang Sun

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 4, 2024

Background Inhibitory control deficits are a core feature of cognitive impairment in schizophrenia, associated with abnormal activation key brain networks. Repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) may help improve inhibitory control, but its specific effects schizophrenia remain uncertain. Methods This study involved 150 participants divided into Real-rTMS, Sham-rTMS, and healthy groups. was assessed using dual-choice oddball task, task-based functional resonance imaging (fMRI) employed to examine neural activity. The Real-rTMS group received active over DLPFC, Sham placebo stimulation. Results exhibited significant improvements both reaction times accuracy compared group, indicating enhanced control. fMRI data showed that activity regions such as cerebellum, insula, thalamus, normalized patterns closely resembling those observed controls. Additionally, revealed restoration further enhancement negative like middle frontal gyrus superior temporal gyrus, which helped reduce interference from irrelevant stimuli. Conclusion rTMS DLPFC improves by modulating positive patterns. These findings highlight dual mechanism through enhances offering promising intervention for schizophrenia. Future research should explore long-term this modulation on broader functions.

Language: Английский

Advanced Intervention Effects of Pulsed and Steady Transcranial Photobiomodulation on Sleep, Mood, and EEG Signal Regulation DOI Open Access
Xuran Zhang,

Xiaojing Miao,

Hui Jiang

et al.

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

ABSTRACT Background Transcranial photobiomodulation (tPBM) enhances cognitive and emotional states. We compared continuous‐wave (CW) pulsed‐wave (PW) tPBM effects on 24 healthy males. Method Participants received 630 nm at 95 mW/cm 2 for 10 min: Sham, CW, or PW (500 Hz). Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State‐Trait Anxiety Inventory (STAI) assessing anxiety), Visual Analog (VAS) stress), Beck Depression Inventory‐II (BDI‐II) evaluating depressive symptoms), 32‐channel EEG baseline, treatment, rest phases. Results Paired t ‐tests showed significantly improved sleepiness, anxiety, stress, depression scores post‐intervention ( p < 0.05). ANOVA analyses indicated increased Alpha Gamma band power versus baseline Conclusion may improve outcomes modulate brain activity, offering therapeutic insights.

Language: Английский

Citations

0
Effects of repetitive transcranial magnetic stimulation on inhibitory control in first-episode schizophrenia: behavioral and neural mechanisms DOI Creative Commons

Sihang Yu,

Shuai Wang, Hang Sun

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 4, 2024

Background Inhibitory control deficits are a core feature of cognitive impairment in schizophrenia, associated with abnormal activation key brain networks. Repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) may help improve inhibitory control, but its specific effects schizophrenia remain uncertain. Methods This study involved 150 participants divided into Real-rTMS, Sham-rTMS, and healthy groups. was assessed using dual-choice oddball task, task-based functional resonance imaging (fMRI) employed to examine neural activity. The Real-rTMS group received active over DLPFC, Sham placebo stimulation. Results exhibited significant improvements both reaction times accuracy compared group, indicating enhanced control. fMRI data showed that activity regions such as cerebellum, insula, thalamus, normalized patterns closely resembling those observed controls. Additionally, revealed restoration further enhancement negative like middle frontal gyrus superior temporal gyrus, which helped reduce interference from irrelevant stimuli. Conclusion rTMS DLPFC improves by modulating positive patterns. These findings highlight dual mechanism through enhances offering promising intervention for schizophrenia. Future research should explore long-term this modulation on broader functions.

Language: Английский

Citations

1