Plant‐derived extracellular vesicles: Current status and challenges for developing a new paradigm in therapeutics development DOI Creative Commons

Hannah Jo,

Su Jin Kang,

Gun-Hee Kim

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Extracellular vesicles (EVs) are nano‐sized surrounded by a lipid bilayer containing bioactive materials, including proteins, nucleic acids, lipids, and metabolites. They function as messengers secreted cells, playing crucial role in cell‐to‐cell communication. Plant‐derived extracellular (P‐EVs), plant being investigated therapeutic agents drug delivery carriers due to their high biocompatibility, productivity, effective cellular delivery, exerting effects through physiological pathways. However, methods for EV production directly from plants P‐EV identification components have not yet been established. A comprehensive understanding of the potential biodistribution P‐EVs is essential application systemic therapeutics carriers. This review covers recent separating explores identification. It also summarizes intrinsic applications engineered P‐EVs. Finally, it provides tailored strategies examining according route administration analyzing application. Given diversity distinctiveness plants, development using shows great promise anticipated create new paradigm therapeutics.

Language: Английский

Plant‐derived extracellular vesicles: Current status and challenges for developing a new paradigm in therapeutics development DOI Creative Commons

Hannah Jo,

Su Jin Kang,

Gun-Hee Kim

et al.

View, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Extracellular vesicles (EVs) are nano‐sized surrounded by a lipid bilayer containing bioactive materials, including proteins, nucleic acids, lipids, and metabolites. They function as messengers secreted cells, playing crucial role in cell‐to‐cell communication. Plant‐derived extracellular (P‐EVs), plant being investigated therapeutic agents drug delivery carriers due to their high biocompatibility, productivity, effective cellular delivery, exerting effects through physiological pathways. However, methods for EV production directly from plants P‐EV identification components have not yet been established. A comprehensive understanding of the potential biodistribution P‐EVs is essential application systemic therapeutics carriers. This review covers recent separating explores identification. It also summarizes intrinsic applications engineered P‐EVs. Finally, it provides tailored strategies examining according route administration analyzing application. Given diversity distinctiveness plants, development using shows great promise anticipated create new paradigm therapeutics.

Language: Английский

Citations

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