Co-occurrence of Periodontitis and Diabetes-Related Complications

Journal of Dental Research, Journal Year: 2023, Volume and Issue: 102(10), P. 1088 - 1097

Published: July 14, 2023

Periodontitis is a common finding among people with diabetes mellitus (DM) and has been cited as DM complication. Whether how periodontitis relates to other diabetes-related complications yet be explored. This study aims examine the clustering of explore pathways linking risk factors. Using data from participants across 3 cycles National Health Nutrition Examination Survey (NHANES) (n = 2,429), we modeled direct indirect factors complications, latent construct comprising periodontitis, cardiovascular diseases, proteinuria, hypertension. Covariates included age, sex, socioeconomic status (SES), smoking, physical activity, healthy diet, alcohol consumption, hemoglobin A1c (HbA1c), dyslipidemia, body mass index (BMI). Sensitivity analyses were performed considering overweight/obesity restricting sample individuals without DM. clustered forming dubbed complications. In NHANES III, higher HbA1c levels BMI, older regular activity directly associated variable addition, diet BMI had total effect on Although SES demonstrated no in was observed using 2011-2014 cycles. analysis showed consistent results. Periodontal tissue breakdown seems co-occur multiple may therefore serve valuable screening tool for well-known

Language: Английский

---

Air Pollution as a Risk Indicator for Periodontitis

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 443 - 443

Published: Feb. 2, 2023

Air pollutants can influence local and systemic inflammation, oxidative stress microbiome composition. Therefore, air pollution may potentially represent an unexplored modifiable risk indicator for periodontitis. The aim of the current cross-sectional study was to investigate epidemiological association between outdoor periodontitis in a representative sample South Korean population.A total 42,020 individuals, which were 35.2 million Koreans, examined. mean annual levels particulate matter 10 μm (PM10), ozone, sulfur dioxide (SO2), nitrogen (NO2) humidity, studied. Periodontitis defined according Community Periodontal Index (CPI ≥ 3). Simple multiple regression analyses using four different models applied.Every 5-μg/m3 increase PM10 (OR = 1.17; 95% confidence interval-CI: 1.11-1.24) 0.005 ppm ozone 1.4; CI: 1.00-1.30) positively associated with prevalence. Conversely, every 5% humidity 0.94; 0.90-0.99) 0.003 NO2 0.93; 0.89-0.96) inversely occurrence.In this nationally population several found be occurrence. Hence, present results suggest that new

Language: Английский

---

Dysregulation of CXCL1 Expression and Neutrophil Recruitment in Insulin Resistance and Diabetes-Related Periodontitis in Male Mice

Diabetes, Journal Year: 2023, Volume and Issue: 72(7), P. 986 - 998

Published: April 14, 2023

Insulin resistance and hyperglycemia are risk factors for periodontitis poor wound healing in diabetes, which have been associated with selective loss of insulin activation the PI3K/Akt pathway gingiva. This study showed that mouse gingiva due to deletion smooth muscle fibroblast receptor (SMIRKO mice) or systemic metabolic changes induced by a high-fat diet (HFD) HFD-fed mice exacerbated periodontitis-induced alveolar bone loss, preceded delayed neutrophil monocyte recruitment impaired bacterial clearance compared their respective controls. The immunocytokines, CXCL1, CXCL2, MCP-1, TNFα, IL-1β, IL-17A, exhibited maximal expression male SMIRKO Targeted overexpression CXCL1 adenovirus normalized prevented both models resistance. Mechanistically, enhanced lipopolysaccharide-induced production human gingival fibroblasts (GFs), via Akt NF-κB activation, were reduced GFs from mice. These results provided first report signaling can enhance endotoxin-induced modulate recruitment, suggesting as new therapeutic direction diabetes. Article Highlights mechanism increased risks tissues diabetes is unclear. We investigated how action modulates progression upregulated chemoattractant, receptors activation. Enhancing resistance-induced delays neutrophils periodontitis. Targeting dysregulation potentially may also improve

Language: Английский

---

Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 21, 2024

Language: Английский

---

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 27, 2024

Abstract The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease humans, immune cells accumulate oral mucosa promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression osteogenic such as osteoblasts periodontal ligament cells. However, detailed mechanism underlying immune–bone periodontitis is not fully understood. Here, we performed single-cell RNA-sequencing analysis on mouse lesions showed that neutrophil–osteogenic crosstalk involved periodontitis-induced loss. displayed marked infiltration neutrophils, silico analyses suggested neutrophils interacted with through cytokine production. Among cytokines expressed oncostatin M (OSM) potently induced RANKL primary osteoblasts, deletion OSM significantly ameliorated Epigenomic data identified OSM-regulated enhancer region cells, mice lacking this decreased loss while maintaining physiological metabolism. These findings shed light regulation during bacterial infection, highlighting novel osteoimmune crosstalk.

Language: Английский

---