Journal of Periodontal Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Aim
Periodontitis
and
peri‐implantitis
are
chronic
inflammatory
diseases
characterized
by
the
destruction
of
supporting
tissues.
Despite
some
similarities,
it
is
essential
to
understand
differences
in
how
these
elicit
unique
host
responses
within
oral
tissues,
including
production
selected
matrix
metalloproteinases
(MMPs)
mediators
involved
tissue
remodelling.
The
aim
this
study
was
evaluate
levels
proteolytic
enzymes
MMP‐1,
MMP‐2,
MMP‐3,
as
well
osteopontin
(OPN),
pentraxin‐3
(PTX3),
thymic
stromal
lymphopoietin
(TSLP)
crevicular
fluid
samples
collected
from
healthy,
periodontitis‐affected,
sites.
Methods
Gingival
(GCF)
peri‐implant
(PICF)
were
healthy
diseased
teeth
implant
sites
163
patients.
OPN,
PTX3,
TSLP
determined
using
commercially
available
immunoassays.
A
linear
mixed
model
procedure
adopted
for
multilevel
analyses,
biomarker
outcome
variable
compare
two
types
diagnostic
accuracy
biomarkers
evaluated
Youden's
index
estimate
sensitivity,
specificity
area
under
curve
(AUC).
Results
higher
at
with
periodontitis
compared
implants.
No
significant
observed
measured
markers
between
diagnosed
those
peri‐implantitis.
highest
potential
found
MMP‐2
(AUC
=
0.74)
0.72).
AUC
(0.82)
tooth
OPN.
Conclusions
findings
indicate
that
enzyme
cytokine
might
be
both
peri‐implantitis,
whereas
proinflammatory
OPN
may
serve
a
periodontitis.
Further
studies
required
confirm
utility
explore
their
clinical
applications.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 1, 2024
Peri-implantitis,
a
complex
condition
that
can
lead
to
dental
implant
failure,
is
characterized
by
inflammatory
destruction
resulting
from
immune
dysregulation.
Oral
microbial
dysbiosis
and
foreign
body
stimulation
are
the
main
factors
contributing
such
dysregulation,
impairing
cell
function
triggering
an
response.
Immune
dysregulation
plays
critical
role
in
pathophysiology
of
peri-implantitis,
impacting
balance
T
subsets,
production
factors,
immune-related
molecular
signaling
pathways.
Understanding
relationship
between
peri-implantitis
crucial
for
developing
targeted
strategies
clinical
diagnosis
individualized
treatment
planning.
This
review
explores
similarities
differences
microenvironment
oral
bacterial
infections
rejection,
analyzes
relevant
pathways,
identifies
new
key
targets
innovative
immunotherapeutic
drugs
effective
personalized
modalities
peri-implantitis.
Additionally,
it
addresses
challenges
potential
directions
translating
immunotherapy
into
practice
offering
insights
bridge
gaps
current
literature
pave
way
future
research.
Drug Development Research,
Journal Year:
2024,
Volume and Issue:
85(2)
Published: March 13, 2024
Abstract
Neutrophils
are
a
crucial
component
of
the
innate
immune
system
and
play
pivotal
role
in
various
physiological
processes.
From
physical
perspective,
hitchhiking
is
considered
phenomenon
efficient
transportation.
The
combination
neutrophils
hitchhikers
has
given
rise
to
effective
delivery
systems
both
vivo
vitro,
thus
become
novel
approach
disease
treatment.
This
article
provides
an
overview
innovative
feasible
application
as
drug
carriers.
It
explores
mechanisms
underlying
neutrophil
function,
elucidates
mechanism
mediated
by
neutrophil‐hitchhiking,
discusses
potential
applications
this
strategy
treatment
cancer,
diseases,
inflammatory
other
medical
conditions.
Clinical Implant Dentistry and Related Research,
Journal Year:
2024,
Volume and Issue:
26(3), P. 631 - 641
Published: March 31, 2024
Abstract
Objective
The
aim
of
this
study
was
to
detect
and
compare
the
tissular
expression
neutrophil
extracellular
traps
(NETs)
in
peri‐implant
periodontal
samples
patients
with
peri‐implantitis,
periodontitis,
controls.
Materials
Methods
An
observational
performed
on
Peri‐implant
and/or
clinical
examinations
were
each
participant.
Tissue
collected
during
tooth/implant
extraction
for
reasons.
Electron
microscopy
analysis,
Picro‐Sirius
red
staining,
immunohistochemical
(CD15),
immunofluorescence
(citrullinated
H3
myeloperoxidase)
techniques
NET‐related
structures
degree
connective
tissue
destruction,
between
groups.
Results
Sixty‐four
included
study:
28
26
10
controls,
a
total
51
implants,
teeth,
control
teeth.
Neutrophil
release
nuclear
content
observed
transmission
electron
microscopy.
Immunohistochemical
analysis
showed
greater
CD15
both
peri‐implantitis
periodontitis
compared
controls
(
p
<
0.001),
presented
lower
levels
collagen
=
0.044;
0.001)
0.001).
Immunofluorescence
citH3
than
one
found
0.003)
0.048).
Conclusions
A
presence
involvement
neutrophils,
as
well
destruction
cases
peri‐implantitis.
higher
markers
mucosal
Interdisciplinary cancer research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
chapter
will
discuss
the
effectiveness
of
predictive
biomarkers
in
predicting
risk
mandibular
osteoradionecrosis
(ORN)
patients
with
head
and
neck
cancers
(HNC)
who
undergo
radiotherapy
(RT)
or
concurrent
chemoradiotherapy
(CCRT).
Furthermore,
it
explore
role
these
pathogenesis
ORN.
Blood-borne
biomarkers,
such
as
neutrophils,
monocytes,
lymphocytes,
platelets,
hemoglobin
(Hb),
albumin,
before
RT
CCRT
have
potential
to
predict
an
increased
ORN
following
treatment.
Various
aspects
pathogenesis,
hypoxia,
vascular
thrombosis,
inflammation,
fibrosis,
been
linked
biological
indicators.
Specific
hemoglobin-to-platelet
ratio
(HPR),
pan-immune-inflammation
value
(PIV),
host
index
(H-index)
proven
effective
incidence
While
exact
functions
cytokines
chemokines
are
not
yet
established,
they
believed
play
critical
roles
development
Predictive
accurately
forecast
HNC
undergoing
CCRT.
Hence,
can
help
categorize
according
their
level
implement
better
preventive
measures.
Journal of Periodontal Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Aim
Periodontitis
and
peri‐implantitis
are
chronic
inflammatory
diseases
characterized
by
the
destruction
of
supporting
tissues.
Despite
some
similarities,
it
is
essential
to
understand
differences
in
how
these
elicit
unique
host
responses
within
oral
tissues,
including
production
selected
matrix
metalloproteinases
(MMPs)
mediators
involved
tissue
remodelling.
The
aim
this
study
was
evaluate
levels
proteolytic
enzymes
MMP‐1,
MMP‐2,
MMP‐3,
as
well
osteopontin
(OPN),
pentraxin‐3
(PTX3),
thymic
stromal
lymphopoietin
(TSLP)
crevicular
fluid
samples
collected
from
healthy,
periodontitis‐affected,
sites.
Methods
Gingival
(GCF)
peri‐implant
(PICF)
were
healthy
diseased
teeth
implant
sites
163
patients.
OPN,
PTX3,
TSLP
determined
using
commercially
available
immunoassays.
A
linear
mixed
model
procedure
adopted
for
multilevel
analyses,
biomarker
outcome
variable
compare
two
types
diagnostic
accuracy
biomarkers
evaluated
Youden's
index
estimate
sensitivity,
specificity
area
under
curve
(AUC).
Results
higher
at
with
periodontitis
compared
implants.
No
significant
observed
measured
markers
between
diagnosed
those
peri‐implantitis.
highest
potential
found
MMP‐2
(AUC
=
0.74)
0.72).
AUC
(0.82)
tooth
OPN.
Conclusions
findings
indicate
that
enzyme
cytokine
might
be
both
peri‐implantitis,
whereas
proinflammatory
OPN
may
serve
a
periodontitis.
Further
studies
required
confirm
utility
explore
their
clinical
applications.
