Translational dental research., Journal Year: 2024, Volume and Issue: unknown, P. 100005 - 100005
Published: Dec. 1, 2024
Language: Английский
Periodontology 2000, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 8, 2025
Abstract To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis systemic diseases through bibliometric visual analysis. A search was conducted using Web Science database, covering period 1989 to 2024. The Medical Subject Headings (MeSH) from US National Library Medicine used categorize conditions, focusing on terms unrelated stomatognathic diseases. analysis included keyword co‐occurrence mapping, co‐authorship, bibliographic coupling, co‐citation Quality indicators such as silhouette score, modularity, centrality were considered assess network's quality. research strategy identified 6106 records, which 1519 met inclusion criteria. revealed that 46.73% literature topic published in last 5 years annual publication trend peaked 2023. Nutritional & Metabolic Diseases ( n = 398), Cardiovascular 335), Female Urogenital Pregnancy Complications 244), Musculoskeletal 182) most representative categories associated with periodontitis. co‐cited journals Journal Periodontology 1412), Clinical 1343), Dental Research 940), 2000 849). USA, China, Brazil, Sweden countries contributed number publications. present study growing evaluating association diseases, highlighting negative impact plethora conditions rising translational interest this relationship. With an aging population, is expected affect people coming decades, presenting significant challenges public health. Improved knowledge is, therefore, essential enable more care, preventive strategies, optimal oral health for patients
Language: Английский
Citations
4
npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 2, 2025
Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.
Language: Английский
Citations
3
Periodontology 2000, Journal Year: 2023, Volume and Issue: 96(1), P. 83 - 94
Published: Dec. 15, 2023
Abstract This review aims to critically analyze the pathways of interaction and pathogenic mechanisms linking periodontitis oral bacteria with initiation/progression cancer at different body compartments. A higher risk head neck has been consistently associated periodontitis. relationship explained by local promotion dysbiosis, chronic inflammation, immune evasion, direct (epi)genetic damage epithelial cells periodontal pathobionts their toxins. Epidemiological reports have also studied a possible link between incidence other malignancies distant sites, such as lung, breast, prostate, digestive tract cancers. Mechanistically, involved, including induction systemic inflammatory state spreading carcinogenic potential. Indeed, may promote low‐grade inflammation phenotypic changes in mononuclear cells, leading release free radicals cytokines, well extracellular matrix degradation, which are all involved metastatic processes. Moreover, transient hematogenous spill out or micro‐aspiration/swallowing virulence factors (i.e., lipopolysaccharides, fimbriae), lead non‐indigenous bacterial colonization multiple microenvironments. These events turn replenish tumor‐associated microbiome thus influence molecular hallmarks cancer. Particularly, specific strains (e.g., Porphyromonas gingivalis Fusobacterium nucleatum ) translocate through enteral routes, being implicated esophageal, gastric, pancreatic, colorectal tumorigenesis modulation gastrointestinal antitumor system tumor‐infiltrating T cells) increased expression pro‐inflammatory/oncogenic genes. Ultimately, potential common factors, relevant comorbidities, upstream drivers, gerovulnerability diseases, explaining cannot be disregarded. The evidence analyzed here emphasizes relevance stimulates future research endeavors.
Language: Английский
Citations
39
Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)
Published: Feb. 21, 2024
Abstract Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable regenerative procedures. This review discusses technologies periodontal regeneration, highlighting current limitations future research areas. The search, performed on MEDLINE database, has identified available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure putty), membranes. Biologicals have been critically analyzed in terms of composition, mechanism action, clinical applications. Although certain degree regeneration predictable class II defects, complete defect closure hardly achieved. Moreover, treating III remains challenging. key properties required functional are discussed, none commercially biomaterials possess all ideal characteristics. Therefore, needed promote advancement more effective targeted therapies Lastly, improving design reporting studies suggested strictly adhering Consolidated Standards Reporting Trials (CONSORT) 2010 statement.
Language: Английский
Citations
15
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 8, 2025
Golgi Protein 73 (GP73) is a Golgi-resident protein that highly expressed in primary tumor tissues. Initially identified as an oncoprotein, GP73 has been shown to promote development, particularly by mediating the transport of proteins related epithelial-mesenchymal transition (EMT), thus facilitating cell EMT. Though our previous review summarized functional roles intracellular signal transduction and its various mechanisms promoting EMT, recent studies have revealed plays crucial role regulating immune microenvironment. can modulate signaling pathways influence cytokine chemokine networks, resulting inflammation caused viral bacterial infection or diseases, leading microenvironment deteriorated. Additionally, extracellular also regulate target cells binding their cell-surface receptors entering acceptor cells, thereby development. In this review, we aim summarize findings, providing insights for future investigations on potential therapeutic ameliorating chronic
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research clinical attention. Although ferroptosis cuproptosis have emerged as areas in medical field, their precise roles pathogenesis periodontitis remain unclear. We aim to systematically summarize current on periodontal disease investigate glutathione pathway autophagy connecting during periodontitis. Further, we propose that homeostatic imbalance copper iron, driven by pathogens, may contribute elevated oxidative stress, representing potential unifying link between involved This article presents comprehensive overview molecular mechanisms underlying periodontitis, offering novel theoretical insights into its therapeutic targets.
Language: Английский
Citations
1
Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1482 - 1482
Published: July 19, 2024
Head and neck cancers (HNCs) constitute a wide range of malignancies originating from the epithelial lining upper aerodigestive tract, including oral cavity, pharynx, larynx, nasal paranasal sinuses, salivary glands. Although lymphomas affecting this region are not conventionally classified as HNCs, they may occur in lymph nodes or mucosa-associated lymphoid tissues within head neck. Oncogenic viruses play crucial role HNC onset. Human papillomavirus (HPV) is extensively studied for its association with oropharyngeal cancers; nevertheless, other oncogenic also contribute to development. This review provides an overview epidemiology, pathogenesis, advancements detection methods associated recognizing HPV's well-established while exploring additional viral connections. Notably, Epstein-Barr virus linked nasopharyngeal carcinoma lymphomas. herpesvirus 8 implicated Kaposi's sarcoma, Merkel cell polyomavirus subsets HNCs. Additionally, hepatitis examined their potential Understanding contributions area critical refining therapeutic approaches. underlines interaction between region, highlighting necessity ongoing research elucidate mechanisms enhance clinical outcomes.
Language: Английский
Citations
7
Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 24, 2024
Abstract Inflammation is a complex physiological process that plays pivotal role in many if not all pathological conditions, including infectious as well inflammatory diseases, like periodontitis and autoimmune disorders. Inflammatory response to periodontal biofilms tissue destruction associated with the release of mediators. Chronic inflammation can promote development cancer. Persistence mediators crucial this process. Quantification monitoring severity relation cancer essential. Periodontitis mainly quantified based on extent attachment loss and/or pocket probing depth, addition bleeding probing. In recent years, studies started investigate indices association diseases. To date, only few reviews have been published focusing relationship between blood cell count, indices, periodontitis. This review presents comprehensive overview different systemic their methods measurement, clinical applications outlines basis underlying cellular molecular mechanisms parameters described. Key are commonly utilized periodontology such neutrophil lymphocyte ratio. platelet ratio, distribution width, plateletcrit, red monocyte delta index, immune index also used hospital settings will be discussed. The roles limitations, diseases treatment
Language: Английский
Citations
7
Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1451 - 1451
Published: July 17, 2024
Aggregatibacter actinomycetemcomitans (A. actinomycetecomitans) is a Gram-negative bacterial species that an essential component of the oral microbiota. Due to its aggregative properties, it plays role in pathogenesis human diseases. The presence surface proteins Fim, Briae, and microvesicles enables bacterium adhere epithelial tooth’s surface. leukotoxin A (LtxA), which important pathogenicity bacterium, has been associated with both periodontitis etiology rheumatoid arthritis (RA). A. actinomycetecomitans also several other systemic diseases complications, such as endocarditis different abscesses. In addition A, possesses virulence factors, including bacteriocins, chemotaxis inhibitory cytotoxic Fc-binding proteins, immunosuppressive lipopolysaccharide collagenase, fibroblast antibiotic resistance determinants, adhesins, invasive factors inhibit function polymorphonuclear leukocytes. ability induce macrophages secrete interleukins IL-1, IL-1β, tumor necrosis factor (TNF) considerable importance. primary etiologic periodontal disease biofilm colonized by anaerobic bacteria. Among these, occupies place facultative bacterium. addition, many contribute potential cause cancer. This article provides overview association various diseases, oncogenic potential, treatment options for infections caused actinomycetecomitans.
Language: Английский
Citations
6
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997
Published: Aug. 28, 2024
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.
Language: Английский
Citations
6