Relationship between periodontitis and systemic diseases: A bibliometric and visual study
Periodontology 2000,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
To
provide
a
comprehensive
and
updated
mapping
of
observational
studies
assessing
the
relationship
between
periodontitis
systemic
diseases
through
bibliometric
visual
analysis.
A
search
was
conducted
using
Web
Science
database,
covering
period
1989
to
2024.
The
Medical
Subject
Headings
(MeSH)
from
US
National
Library
Medicine
used
categorize
conditions,
focusing
on
terms
unrelated
stomatognathic
diseases.
analysis
included
keyword
co‐occurrence
mapping,
co‐authorship,
bibliographic
coupling,
co‐citation
Quality
indicators
such
as
silhouette
score,
modularity,
centrality
were
considered
assess
network's
quality.
research
strategy
identified
6106
records,
which
1519
met
inclusion
criteria.
revealed
that
46.73%
literature
topic
published
in
last
5
years
annual
publication
trend
peaked
2023.
Nutritional
&
Metabolic
Diseases
(
n
=
398),
Cardiovascular
335),
Female
Urogenital
Pregnancy
Complications
244),
Musculoskeletal
182)
most
representative
categories
associated
with
periodontitis.
co‐cited
journals
Journal
Periodontology
1412),
Clinical
1343),
Dental
Research
940),
2000
849).
USA,
China,
Brazil,
Sweden
countries
contributed
number
publications.
present
study
growing
evaluating
association
diseases,
highlighting
negative
impact
plethora
conditions
rising
translational
interest
this
relationship.
With
an
aging
population,
is
expected
affect
people
coming
decades,
presenting
significant
challenges
public
health.
Improved
knowledge
is,
therefore,
essential
enable
more
care,
preventive
strategies,
optimal
oral
health
for
patients
Language: Английский
Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 7, 2025
This
study
aimed
to
investigate
the
association
between
serum
calcium
levels
and
periodontitis
in
a
U.S.
adult
population,
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2009-2014.
Data
were
analyzed
8,601
participants
aged
over
30
years,
who
categorized
based
on
presence
or
absence
of
periodontitis.
Serum
measured
standardized
NHANES
protocols,
status
was
determined
through
clinical
oral
examinations.
To
assess
relationship
periodontitis,
multivariate
logistic
regression
models
applied
across
three
adjustment.
Additionally,
trend
tests
subgroup
analyses
conducted
explore
associations
different
demographic
subgroups.
A
smoothing
curve
fitting
threshold
effect
analysis
also
performed
examine
potential
nonlinear
relationships.
After
adjusting
multiple
covariates,
highest
quartile
showed
an
18%
reduced
risk
compared
those
lowest
(OR
=
0.82,
95%
CI:
0.71-0.95,
p
0.0083;
for
0.0057).
The
remained
stable
various
Smoothing
indicated
negative
correlation
though
without
significant
inflection
point
at
2.48
mmol/L
(p
0.094).
Elevated
appear
be
associated
with
lower
adults.
These
findings
suggest
that
adequate
intake
may
play
role
prevention,
providing
valuable
insight
guidance
nutritional
preventive
strategies
periodontal
health.
Language: Английский
Host Markers of Periodontal Diseases: Meta‐Analysis of Diagnostic Accuracy Studies
Journal Of Clinical Periodontology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
ABSTRACT
Objective
To
identify
host
markers
with
optimal
diagnostic
performance
for
clinical
implementation
in
the
diagnosis
of
periodontal
diseases
and
prediction
future
disease
progression
and/or
resolution.
Material
Methods
Cross‐sectional
prospective
studies
≥
20
participants
per
group,
reporting
accuracy
(e.g.,
area
under
curve
[AUC])
(focused
question
1
[FQ1]),
periodontitis
progression/relapse
(FQ2)
or
resolution
(FQ3)
were
searched
three
electronic
databases.
Meta‐analyses
estimating
(DA)
individual
grouped
salivary
gingival
crevicular
fluid
(GCF)
independently
performed
whenever
two
more
identified.
Results
Sixty‐one
eligible
identified,
which
13
included
meta‐analyses
FQ1
(discrimination
between
health
periodontitis).
Matrix
metalloproteinase‐8
(MMP‐8)
was
most
reported
biomarker
both
saliva
GCF,
comparable
AUC
(0.70–0.90),
sensitivity
(0.49–0.84)
specificity
(0.62–0.79)
sample
types.
Cytokines
had
good
ability
discrimination
periodontitis/gingivitis
versus
health,
although
they
substantially
less
accurate
gingivitis.
Combinations
cytokines
MMPs
tended
to
increase
overall
but
without
significant
improvement
case
discrimination.
Bone
best
performing
group
(AUC
=
0.91)
when
compared
0.86)
0.77).
GCF
microRNAs
(MiRs)
a
singly
meta‐analysed
biomarkers
demonstrating
0.79.
Conclusion
Reported
on
exhibit
serious
limitations
regarding
validation
standards,
being
main
cause
lack
progress
classification.
Disease‐specific
such
as
bone
showed
better
(from
limited
number
studies)
MMPs.
Language: Английский
Mesaconate from Bacillus subtilis R0179 Supernatant Attenuates Periodontitis by Inhibiting Porphyromonas gingivalis in Mice
Journal of Periodontal Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 19, 2024
ABSTRACT
Aims
This
research
sought
to
assess
the
efficacy
of
Bacillus
subtilis
(
B.
)
R0179
and
explore
potential
metabolites
in
mitigating
experimental
periodontitis
mice
induced
by
Porphyromonas
gingivalis
P.
ATCC
33277.
Methods
was
administered
8‐week‐old
male
C57BL/6J
with
periodontitis.
Oral
load
33277
periodontal
tissue
loss
were
quantified.
The
cell‐free
supernatant
(CFS)
separated
its
anti
‐
effect.
Proteomic
metabolomic
analyses
identified
antibacterial
components
CFS,
further
evaluated
for
anti‐
effects.
Results
significantly
reduced
levels
mitigated
mice.
rather
than
inactivated
cells,
exhibited
activity.
mesaconate
citraconate
as
key
agents.
Disk
diffusion
assays
confirmed
against
,
while
had
no
Mesaconate
showed
a
dose‐dependent
reduction
population
Conclusion
These
findings
highlight
metabolite
promising
candidates
therapeutic
development
inhibiting
effectively.
Language: Английский