Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial DOI Creative Commons
Alper Yüzbaşıoğlu, Cennet Neslihan Eroğlu

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

Alveolar osteitis is a type of small-scale osteomyelitis the alveolar bone that occurs after tooth extraction, etiology which remains unknown, and alternative methods are being investigated for its treatment. The aim this study was to compare effectiveness advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), Alveogyl (butamben, idoform, eugenol), have shown success in treatment osteitis, with pentoxifylline (PTX) determine whether PTX could be an osteitis. This included 80 healthy volunteers diagnosed extraction sockets their mandibular first, second, third molars. patients were divided into four groups, 20 each group: A-PRF, PBM, PTX, Alveogyl. After physiological saline irrigation, treated according respective group. followed up on 2nd, 4th, 7th, 14th days. Primary outcomes pain assessment evaluation soft tissue healing. Pain assessed via visual analog scale (VAS), healing evaluated Landry Healing Index (LHI), granulation measured. Age sex used as variables. data analyzed ANOVA post hoc tests groups. There no statistically significant difference mean VAS score between groups (p > 0.05). However, degree reduction increased following order: In LHI data, there scores favored preoperatively PBM at 2nd week < Statistically differences observed measurements preoperative day, well Days 4 7, favor Day 7 greatest increase A-PRF group, whereas change did not produce healing, although periods when it showed results similar those PBM. score, terms age within time followed. findings indicate has efficacy wound analgesic properties used, does offer advantages. Compared other methods, provided better particularly regarding retrospectively registered clinical trial registry number TCTR20231014003 14.10.2023.

Language: Английский

Histomorphometric and immunohistochemical assessment of treated dentin matrix delivered by platelet-rich fibrin for socket preservation in rabbit model DOI Creative Commons

Eman M. Sedek,

Nesma Khalil, Mohamed M. Abdul-Monem

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

This study aimed to test treated dentine matrix (TDM) with platelet-rich fibrin (PRF) for socket preservation, following tooth extraction compared synthetic grafting material Nanobone (NB) PRF. Study was conducted on New Zealand rabbits (n = 40). Bilateral first lower premolar performed, one side left empty and the other filled in group 20). In 20), TDM/PRF while NB/ After three months, were euthanized, area examined using haematoxylin eosin (H&E) Goldner Masson trichrome stains. One-way ANOVA post-hoc tests used histomorphometric analysis. Immunohistochemical analysis of osteopontin carried out. Histological NB/PRF groups showed a higher level new bone formation comparison control PRF groups. Histomorphometric revealed significant increase after months (p 0.042 p < 0.001), respectively. There no differences percentages unmineralized between at both intervals 0.375 0.352, respectively). Regarding immunohistochemistry, highest immune expression followed by TDM/PRF. No detected 0.234 & 0.607 ability form sockets rabbits. can be as an alveolar preservation.

Language: Английский

Citations

0
Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial DOI Creative Commons
Selene Barone, Francesco Bennardo, Marianna Salviati

et al.

Head & Face Medicine, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 22, 2025

Third molar surgery is associated with various postoperative complications (PC). Different strategies, including the application of platelet-rich fibrin (PRF), have been implemented to reduce PC. Digital technologies proven useful in objectively assessing facial swelling. This study aimed evaluate effect PRF on reducing swelling after lower third using a 3D face scanner. A randomized split-mouth clinical trial was set up and 32 patients (18 years), requiring extraction both mandibular molars, were recruited at Oral Surgery Clinic Magna Graecia University Catanzaro. The primary predictive variable or not plugs membranes post-extraction socket. Primary outcome recorded scanner preoperatively (T0), three (T1) seven (T2) days. Qualitative quantitative data analysis conducted following an automated standardized imaging workflow Slicer software. Secondary variables trismus, by measuring maximum buccal opening caliper, pain, visual analogue scale (VAS), duration surgery. Descriptive bivariate performed setting significance level $$\:\alpha\:$$ = 0.05. All exhibited significant increase T1, followed subsequent reduction from day 3 7, slight persistence edema observed seventh day. No emerged statistical conducted. Linear differences group reported improved values only T1-T2 T0-T2 phases analysis. Volumetric favored compared control all phases. VAS T2, group. Application sockets showed effectiveness Its advantages, accessibility, cost-effectiveness, absence adverse reactions, make it optimal treatment choice post-surgical sequelae.

Language: Английский

Citations

0
Applications of Platelet-Rich Fibrin (PRF) Membranes Alone or in Combination with Biomimetic Materials in Oral Regeneration: A Narrative Review DOI Creative Commons

Javier Valenzuela-Mencia,

Francisco Javier Manzano‐Moreno

Biomimetics, Journal Year: 2025, Volume and Issue: 10(3), P. 172 - 172

Published: March 11, 2025

Platelet-rich fibrin (PRF) membranes are a biomaterial derived from the patient’s own blood, used in different medical and dental areas for their ability to promote healing, tissue regeneration, reduce inflammation. They obtained by centrifuging which separates components concentrates platelets growth factors matrix. This material is then moulded into membrane that can be applied directly tissues. The use of these PRF often associated with biomimetic materials such as deproteinized bovine bone mineral (DBBM), β-tricalcium phosphate (β-TCP), enamel matrix derivative (EMD), hydroxyapatite (HA). Different indications have been proposed, like alveolar ridge preservation, augmentation, guided regeneration (GTR), sinus floor augmentation. aim this narrative review check state-of-the-art analyze existing gaps combination

Language: Английский

Citations

0
EFFECT OF CLINDAMYCIN ON HUMAN OSTEOBLASTS TREATED WITH ZOLEDRONATE: AN IN VITRO STUDY DOI

Hunayda Bumedien-Abdelgani,

Francisco Javier Manzano‐Moreno, Anabel González‐Acedo

et al.

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106247 - 106247

Published: April 1, 2025

Language: Английский

Citations

0
Efficacy of concentrated growth factor combined with coronally advanced flap in the treatment of gingival recession: a systematic review and meta-analysis DOI Creative Commons
Yifan Yang,

Li-Wei Ou-Yang,

Chang Cao

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

This study aims to evaluate the efficacy of combining coronally advanced flap (CAF) technique with concentrated growth factor (CGF) in treatment gingival recession (GR), and compare this approach other alternative treatments. systematic review meta-analysis included randomized controlled trials (RCTs) comparing CAF combined CGF treatments for root coverage procedures. Included studies evaluated systemically healthy adults (> 18 years) Miller Class I/II or Cairo RT1 recessions. Primary outcomes were complete (CRC) mean (MRC); secondary changes keratinized tissue width (KTW), thickness (GT), clinical attachment level (CAL), (RW), depth (RD), probing (PD). A comprehensive search was conducted across multiple databases, including PubMed, Scopus, Cochrane Library, Web Science, Embase, up November 9, 2024. The protocol prospectively registered PROSPERO (CRD42024556815). Statistical analyses performed using Review Manager 5.4.1. Eight meta-analysis. Compared alone, combination significantly improved CRC (OR = 1.79, P 0.04), MRC (MD 10.38%, KTW 0.40 mm, 0.02), GT 0.26 < 0.00001), CAL 0.36 0.03). connective graft (CTG) showed superior compared + 0.25, 0.009). However, no significant differences found between CTG MRC, CAL, KTW, RD, RW, PD. Additionally, observed when PRF all parameters (all > 0.05). findings indicate that CAF/CGF improves treating GR may be a viable is not applicable. Further are needed validate GR. In cases where applicable, serve as class I II

Language: Английский

Citations

0
Imaging Characteristics of CBCT as the Gold Standard for Diagnosis and Follow-up of MRONJs DOI
Verônica Caroline Brito Reia, Aristéa Ribeiro Carvalho, Vivian Palata Viola

et al.

Current Oral Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 11, 2025

Language: Английский

Citations

0
Does platelet‐rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review DOI Creative Commons
Enrica Giammarinaro, Nicola Baldini, Ugo Covani

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

Citations

0
In vitro comparison of the effects of titanium-prepared platelet-rich fibrin and leukocyte platelet-rich fibrin on osteoblast behavior and their gen expression DOI Creative Commons

Melike Baygın,

Aris Çakiris, Ayşegül Yabacı

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

To compare the effects of titanium-prepared platelet-rich fibrin (T-PRF) and leukocyte (L-PRF) on osteoblasts. Venous blood samples were collected from ten volunteer patients to obtain T-PRF L-PRF. The group was labelled as Group T, L-PRF L, control group, which includes only osteoblasts, K. PRF added cultured osteoblast cells cell proliferation assessed using an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. effect different groups observed for 72 h results analysed statistically. Additionally, real-time polymerase chain reaction (RT-PCR) conducted evaluate gene expression levels COL1A1, ALP, OCN, RUNX2 within 48 h. We found that at 24 significantly lower than those (p = 0.036 p < 0.001, respectively). showed increase followed by a decrease seen both 24–48 48–72-hour intervals. changes in COLA1, genes did not differ among > 0.05). In this study, we investigated over 72-hour period. Both improved proliferation, however consistent up h, contrast group. No differences found. However, osteoblastic marker can be expressed longer time periods. Therefore, long-term studies are needed.

Language: Английский

Citations

0
Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial DOI Creative Commons
Alper Yüzbaşıoğlu, Cennet Neslihan Eroğlu

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

Alveolar osteitis is a type of small-scale osteomyelitis the alveolar bone that occurs after tooth extraction, etiology which remains unknown, and alternative methods are being investigated for its treatment. The aim this study was to compare effectiveness advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), Alveogyl (butamben, idoform, eugenol), have shown success in treatment osteitis, with pentoxifylline (PTX) determine whether PTX could be an osteitis. This included 80 healthy volunteers diagnosed extraction sockets their mandibular first, second, third molars. patients were divided into four groups, 20 each group: A-PRF, PBM, PTX, Alveogyl. After physiological saline irrigation, treated according respective group. followed up on 2nd, 4th, 7th, 14th days. Primary outcomes pain assessment evaluation soft tissue healing. Pain assessed via visual analog scale (VAS), healing evaluated Landry Healing Index (LHI), granulation measured. Age sex used as variables. data analyzed ANOVA post hoc tests groups. There no statistically significant difference mean VAS score between groups (p > 0.05). However, degree reduction increased following order: In LHI data, there scores favored preoperatively PBM at 2nd week < Statistically differences observed measurements preoperative day, well Days 4 7, favor Day 7 greatest increase A-PRF group, whereas change did not produce healing, although periods when it showed results similar those PBM. score, terms age within time followed. findings indicate has efficacy wound analgesic properties used, does offer advantages. Compared other methods, provided better particularly regarding retrospectively registered clinical trial registry number TCTR20231014003 14.10.2023.

Language: Английский

Citations

0