Transcutaneous Auricular Vagus Nerve Stimulation Enhances Emotional Processing and Long‐Term Recognition Memory: Electrophysiological Evidence Across Two Studies DOI Creative Commons
Carlos Ventura‐Bort, Manon Giraudier, Mathias Weymar

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(3)

Published: March 1, 2025

ABSTRACT Recently, we found that continuous transcutaneous auricular vagus nerve stimulation (taVNS) facilitates the encoding and later recollection of emotionally relevant information, as indicated by differences in late positive potential (LPP), memory performance, ERP Old/New effect. Here, aimed to conceptually replicate extend these findings investigating effects different time‐dependent taVNS protocols. In Study 1, an identical paradigm our previous study was employed with interval (30‐s on/off). Participants viewed unpleasant neutral scenes on two consecutive days while receiving or sham completed a recognition test 1 week later. Replicating results, images encoded under taVNS, compared stimulation, elicited larger amplitudes earlier window LPP during encoding, well more pronounced differences. However, no performance were found. 2, followed up synchronizing cycle image presentation determine for off cycles. We could enhancing brain potentials (early differences) improved recollection‐based both images, independently cycle. Overall, results suggest increases electrophysiological correlates emotional retrieval time‐independent manner, substantiating nerve's role processing formation, opening new venues improving mnemonic processes clinical non‐clinical populations.

Language: Английский

Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis DOI Creative Commons

Ipek Pervaz,

Lilly Thurn,

Cecilia Vezzani

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: 18(2), P. 148 - 157

Published: Jan. 29, 2025

Language: Английский

Citations

2
Gastrointestinal Interoception in Eating Disorders: Charting a New Path DOI Creative Commons
Sahib S. Khalsa, Laura A. Berner, Lisa M. Anderson

et al.

Current Psychiatry Reports, Journal Year: 2022, Volume and Issue: 24(1), P. 47 - 60

Published: Jan. 1, 2022

Abnormal interoception has been consistently observed across eating disorders despite limited inclusion in diagnostic conceptualization. Using the alimentary tract as well recent developments interoceptive neuroscience and predictive processing a guide, current review summarizes evidence of gastrointestinal dysfunction disorders.

Language: Английский

Citations

64
Transcutaneous cervical vagus nerve stimulation improves sensory performance in humans: a randomized controlled crossover pilot study DOI Creative Commons
Michael Jigo, Jason B. Carmel, Qi Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 17, 2024

Abstract Accurate senses depend on high-fidelity encoding by sensory receptors and error-free processing in the brain. Progress has been made towards restoring damaged receptors. However, methods for on-demand treatment of impaired central are scarce. Prior invasive studies demonstrated that continuous vagus nerve stimulation (VNS) rodents can activate locus coeruleus-norepinephrine system to rapidly improve processing. Here, we investigated whether transcutaneous VNS improves performance humans. We conducted three sham-controlled experiments, each with 12 neurotypical adults, measured effects metrics auditory visual performance, heart rate variability (HRV). Continuous was delivered cervical (tcVNS) or auricular (taVNS) branches while participants performed psychophysics tasks passively viewed a display. Relative sham stimulation, tcVNS improved 37% ( p = 0.00052) 23% 0.038). Participants lower during conditions experienced larger tcVNS-evoked improvements 0.0040). Lastly, increased HRV passive viewing, corroborating vagal engagement. No evidence an effect taVNS observed. These findings validate effectiveness humans position it as method interventions impairments associated dysfunction.

Language: Английский

Citations

13
Transcutaneous auricular vagus nerve stimulation modulates the processing of interoceptive prediction error signals and their role in allostatic regulation DOI Creative Commons
Carlos Ventura‐Bort, Mathias Weymar

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(3)

Published: Feb. 15, 2024

It has recently been suggested that predictive processing principles may apply to interoception, defined as the of hormonal, autonomic, visceral, and immunological signals. In current study, we aimed at providing empirical evidence for role cardiac interoceptive prediction errors signals on allostatic adjustments, using transcutaneous auricular vagus nerve stimulation (taVNS) a tool modulate afferents. within-subject design, participants performed cardiac-related task (heartbeat counting task) under taVNS sham stimulation, spaced 1-week apart. We observed taVNS, in contrast facilitated maintenance accuracy levels over time (from initial, stimulation-free, baseline block subsequent blocks), suggesting have helped maintain engagement afferent During task, compared sham, produced higher heart-evoked potentials (HEP) amplitudes, potential readout measure error processing. Further analyses revealed positive relation between adjustments-as measured by heart rate variability (HRV)-was mediated HEP amplitudes. Providing initial support accounts our results suggest increase precision with which are processed, favoring their influence adjustments.

Language: Английский

Citations

12
Non‐Invasive Auricular Vagus Nerve Stimulation Decreases Heart Rate Variability Independent of Caloric Load DOI Creative Commons
Kristin Kaduk, A. Petrella, Sophie J. Müller

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(2)

Published: Feb. 1, 2025

ABSTRACT The vagus nerve is crucial in regulating physiological functions, including the cardiovascular system. While heart rate (HR) and its variability (HRV) may provide non‐invasive proxies of cardiac vagal activity, transcutaneous auricular stimulation (taVNS) has yielded mixed effects, with limited research on right branch stimulation. In a randomized crossover study 36 healthy participants, we investigated taVNS effects HR HRV indexed by SDRR, RMSSD, HF‐HRV, LF/HF ratio. To assess impact side (left vs. ear) indices interaction state, recorded electrocardiograms four sessions per person, covering three session phases: baseline, during (taVNS sham), post‐milkshake consumption First, found moderate evidence against affecting (BF 10 = 0.21). Second, decreased (multivariate p 0.004) independent strong for RMSSD 15.11) HF‐HRV 11.80). Third, taVNS‐induced changes were comparable across sides stronger than sham, indicating consistent side. We conclude that reduces as SDRR without altering HR, contradicting assumption se increases cardiovagal activity increased due to stimulating afferents. Instead, our results support role afferent activation arousal. Crucially, both can safely modulate system increasing risk bradycardia or causing adverse events offering new treatment possibilities.

Language: Английский

Citations

1
Prefrontal executive function enhanced by prior acute inhalation of low-dose hypoxic gas: Modulation via cardiac vagal activity DOI
Dongmin Lee, Yudai Yamazaki, Ryuta Kuwamizu

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 310, P. 121139 - 121139

Published: March 17, 2025

Language: Английский

Citations

1
The Vagus Nerve as a Gateway to Body Ownership: taVNS Reduces Susceptibility to a Virtual Version of the Cardiac and Tactile Rubber Hand Illusion DOI Creative Commons
Alisha Vabba, Keisuke Suzuki,

Milica Doric

et al.

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(3)

Published: March 1, 2025

ABSTRACT Transcutaneous auricular vagus nerve stimulation (taVNS) has been shown to influence cognitive and emotional function enhance interoceptive awareness. This study investigates if taVNS effects extend the experience of body ownership, as measured via susceptibility rubber hand illusion (RHI) in a virtual reality setting. The experiment involved 27 participants who underwent real sham two separate sessions while experiencing synchronous or asynchronous visuo‐cardiac visuo‐tactile feedback on arm place their own. Results indicated that active compared decreased sensitivity both cardiac tactile trials. Specifically, greater proprioceptive drift difference (PDD) toward was observed for trials only during ( t (26) = −4.58, p bonf < 0.001) but not 1.00) stimulation. A similar pattern also subjective where led ownership than −3.52, 0.010) These findings suggest might making individuals more attuned bodily signals less susceptible illusions. Additionally, physiological measures such heart rate (HR), variability (HRV), skin sympathetic nervous activity (SKNA) were assessed explore autonomic taVNS. We decrease HR 4.30, 0.001), an increase SKNA −4.40, −4.85, 0.002). contribute understanding nerve's role integrating visceral somatosensory signals, with implications clinical applications conditions characterized by altered interoception ownership.

Language: Английский

Citations

1
Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis DOI Creative Commons
Manon Giraudier, Carlos Ventura‐Bort, Andreas M. Burger

et al.

Brain stimulation, Journal Year: 2022, Volume and Issue: 15(6), P. 1378 - 1388

Published: Sept. 30, 2022

Language: Английский

Citations

33
No evidence for a modulating effect of continuous transcutaneous auricular vagus nerve stimulation on markers of noradrenergic activity DOI
Martina D’Agostini, Andreas M. Burger,

Gustavo Villca Ponce

et al.

Psychophysiology, Journal Year: 2022, Volume and Issue: 59(4)

Published: Jan. 6, 2022

Abstract Although transcutaneous auricular vagus nerve stimulation (taVNS) is thought to increase central noradrenergic activity, findings supporting such mechanism are scarce and inconsistent. This study aimed investigate whether taVNS modulates indirect markers of phasic tonic activity. Sixty‐six healthy participants performed a novelty auditory oddball task twice on separate days: once while receiving (left cymba concha), during sham earlobe) stimulation. To maximize potential effects, the was delivered continuously (frequency: 25 Hz; width: 250 μs) at an intensity individually calibrated maximal level below pain threshold. The administered 10 min before maintained throughout session. Event‐related pupil dilation (ERPD) target stimuli pre‐stimulus baseline size were assessed as respectively. Prior end stimulation, rest, cortisol, salivary alpha‐amylase Finally, we explored effect cardiac vagal respiratory rate, flow rate. Results showed greater ERPD both compared standard in task. In contrast our hypotheses, did not impact any tested markers. Our strongly suggest that continuous concha with parameters ineffective activity via pathway.

Language: Английский

Citations

30
The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine DOI Creative Commons
Pradeep S. Rajendran, Joseph Hadaya, Sahib S. Khalsa

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 156, P. 190 - 200

Published: Jan. 12, 2023

Language: Английский

Citations

20