Aperture Neuro,
Journal Year:
2025,
Volume and Issue:
5
Published: March 20, 2025
Aging
is
associated
with
alterations
in
resting-state
functional
connectivity
(RSFC),
which
can
impact
executive
functions
such
as
attention
and
inhibitory
control;
however,
the
extent
to
lifelong
musical
practice
influence
these
age-related
changes
remains
unclear.
In
this
paper,
we
investigated
RSFC
relationship
between
among
amateur
singers,
instrumentalists
active
controls.
We
analyzed
fMRI
(rs-fMRI)
data
using
independent
component
analysis
(ICA)
collected
from
106
healthy
adults,
including
31
37
38
controls,
aged
20
88
years.
Attention
was
measured
Test
of
Listening
(TAiL),
control
cognitive
flexibility
were
Colour-Word
Interference
(CWIT),
working
memory
Digit
Span
Task.
Our
results
indicate
that
while
aging
both
higher
lower
RSFC,
reductions
are
more
prominent.
The
musicians
exhibited
fewer
changes,
distinct
patterns
association
performance
for
singers
instrument
players.
complex
varies
across
resting
state
networks,
regions,
tasks.
end
paper
by
proposing
a
framework
interpretation
neurocognitive
based
on
our
findings.
Human Brain Mapping,
Journal Year:
2024,
Volume and Issue:
45(5)
Published: March 29, 2024
Abstract
Healthy
aging
is
associated
with
a
heterogeneous
decline
across
cognitive
functions,
typically
observed
between
language
comprehension
and
production
(LP).
Examining
resting‐state
fMRI
neuropsychological
data
from
628
healthy
adults
(age
18–88)
the
CamCAN
cohort,
we
performed
state‐of‐the‐art
graph
theoretical
analysis
to
uncover
neural
mechanisms
underlying
this
variability.
At
level,
our
findings
suggest
that
LP
not
an
isolated
function
but
modulated
throughout
lifespan
by
extent
of
inter‐cognitive
synergy
semantic
domain‐general
processes.
cerebral
show
default
mode
network
(DMN)
suppression
coupled
fronto‐parietal
(FPN)
integration
way
for
brain
compensate
effects
dedifferentiation
at
minimal
cost,
efficiently
mitigating
age‐related
in
LP.
Relatedly,
reduced
DMN
midlife
could
compromise
ability
manage
cost
FPN
integration.
This
may
prompt
older
adopt
more
cost‐efficient
compensatory
strategy
maintains
global
homeostasis
expense
performances.
Taken
together,
propose
represents
critical
neurocognitive
juncture
signifies
onset
decline,
as
gradually
lose
control
over
representations.
We
summarize
novel
synergistic,
economical,
nonlinear,
emergent,
model,
integrating
connectomic
dimensions
within
complex
system
perspective.
Exploration of Medicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 797 - 821
Published: Nov. 8, 2024
Age-related
changes
in
the
brain
cause
cognitive
decline
and
dementia.
In
recent
year’s
researchers’
extensively
studied
relationship
between
age
related
functional
connectivity
(FC)
Those
studies
explore
alterations
FC
patterns
observed
aging
neurodegenerative
disorders
using
techniques
such
as
resting-state
magnetic
resonance
imaging
(rs-fMRI),
electroencephalography
(EEG)
coherence
analysis,
graph
theory
approaches.
The
current
review
summarizes
findings,
which
highlight
impact
of
on
disease
progression
these
emphasize
importance
understanding
neural
for
early
detection
intervention.
findings
underscore
complexity
need
further
research
to
differentiate
normal
from
pathological
conditions.
rs-fMRI
is
essential
studying
associated
with
pathology
by
capturing
coherent
fluctuations
activity
during
rest,
providing
insights
into
without
task-related
confounds.
Key
networks
default
mode
network
front
parietal
control
are
crucial
revealing
age-related
changes.
Despite
challenges
like
neurovascular
uncoupling
data
complexity,
ongoing
advancements
promise
improved
clinical
applications
across
lifespan.
EEG
magnetoencephalography
(MEG)
cost-effective
high
temporal
resolution,
allowing
detailed
study
rhythms
FC.
Recent
EEG/MEG’s
potential
Alzheimer’s
identifying
patterns.
Integration
machine
learning
enhances
diagnostic
accuracy,
although
validation
necessary.
Graph
offers
a
quantitative
framework
analyze
networks,
distinct
topological
differences
healthy
Future
should
expand
exploration
diverse
beyond
mild
impairment,
integrating
neuroimaging
refine
precision
deepen
function
connectivity.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
Many
brain
diseases
and
disorders
lack
objective
measures
of
function
as
indicators
pathology,
which
has
recently
spurred
the
use
normative
modelling
in
neuroimaging.
Normative
models
characterize
normal
variation
measurements
given
sex
age,
thereby
allowing
identification
abnormalities
deviations
from
normal.
is
typically
based
on
predicting
functional
connectivity
(FC)
between
each
pair
regions.
But
human
an
extremely
integrated
organ,
disease
often
widespread
effects
that
are
not
well
captured
by
piecemeal
analyses,
i.e.
connection
connection.
We
propose
Functional
Connectivity
Integrative
Modelling
(FUNCOIN),
developing
a
whole-brain
model
FC
large
resting-state
fMRI
data
set
captures
whole-network-level
changes
associated
with
age.
This
can
significantly,
substantially,
uncover
abnormal
patterns
Parkinson’s
patients
even
scans
up
to
5.5
years
before
diagnosis.
Frontiers in Aging Neuroscience,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 15, 2025
Asymptomatic
carotid
stenosis
(ACS)
is
an
independent
risk
factor
for
ischemic
stroke
and
vascular
cognitive
impairment,
affecting
function
across
multiple
domains.
This
study
aimed
to
explore
differences
in
static
dynamic
intrinsic
functional
connectivity
temporal
dynamics
between
patients
with
ACS
those
without
stenosis.
We
recruited
30
unilateral
moderate-to-severe
(stenosis
≥
50%)
demographically-matched
healthy
controls.
All
participants
underwent
neuropsychological
testing
3.0T
brain
MRI
scans.
Resting-state
(rs-fMRI)
was
used
calculate
both
connectivity.
Dynamic
component
analysis
(dICA)
employed
extract
circuits/networks
detect
time-frequency
modulation
at
the
circuit
level.
Further
imaging-behavior
associations
identified
patterns
that
reflect
decline.
showed
altered
regions
networks
compared
Increased
observed
inferior
parietal
lobule,
frontal
lobe,
lobe.
dICA
further
revealed
changes
frequency
of
salience
network.
Significant
variability
were
found
fronto-parietal
network,
dorsal
attention
sensory-motor
language
visual
The
parameters
these
also
related
overall
cognition
memory.
These
results
suggest
involves
not
only
large-scale
network
but
variations,
which
parallel
memory
recall.
Journal of Integrative Neuroscience,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 7, 2025
Resting
state
networks
(RSNs)
of
the
brain
are
characterized
as
correlated
spontaneous
time-varying
fluctuations
in
absence
goal-directed
tasks.
These
can
be
local
or
large-scale
spanning
brain.
The
study
spatiotemporal
properties
such
has
helped
understand
brain’s
fundamental
functional
organization
under
healthy
and
diseased
states.
As
we
age,
these
change.
Moreover,
RSNs
exhibit
neural
plasticity
to
compensate
for
loss
cognitive
functions.
This
narrative
review
aims
summarize
current
knowledge
from
magnetic
resonance
imaging
(fMRI)
studies
on
age-related
alterations
RSNs.
Underlying
mechanisms
influencing
changes
discussed.
Methodological
challenges
future
directions
also
addressed.
By
providing
an
overview
this
field,
guide
research
endeavors
aimed
at
promoting
aging
developing
effective
interventions
impairment
neurodegenerative
diseases.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Ageing
individuals
often
experience
cognitive
decline
and
intrinsic
functional
connectivity
(FC)
changes.
Psychological
resilience,
a
personality
trait
that
reflects
the
capacity
to
adapt
cope
with
age-related
challenges,
plays
key
role
in
mitigating
decline.
In
this
study
involving
101
older
adults,
we
investigated
how
psychological
resilience
influences
measured
by
processing
speed.
Particularly,
obtained
resting-state
magnetic
resonance
imaging
(fMRI)
assess
FC,
represented
degree
centrality,
modulates
relationship
between
Our
results
indicated
while
positively
predicted
speed,
was
mainly
driven
education.
Additionally,
centrality
of
both
thalamus
caudate
negatively
correlated
speed
resilience.
Notably,
significantly
mediated
These
findings
suggest
could
protect
against
via
its
influence
on
FC
caudate,
highlighting
these
areas
as
potential
intervention
targets
for
reducing
ageing
people.
