Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 10, 2024

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Developmental peaks include (1) the presence then absence a 9-10 Hz alpha peak between 2-6 months, (2) high beta (20-30 Hz) 4-18 (3) emergence low (12-20 some infants after six months age. We hypothesized that may reflect maturation thalamocortical network development. Infant anesthesia studies observe GABA-modulating anesthetics do not induce mediated frontal coherence until 10-12 Using small cohort ( n = 23) with before during anesthesia, we provide preliminary evidence have higher anesthesia-induced compared to those without peak.

Language: Английский

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Aperiodic and Hurst EEG exponents across early human brain development: A systematic review

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 68, P. 101402 - 101402

Published: June 7, 2024

In electroencephalographic (EEG) data, power-frequency slope exponents (1/f_β) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/f β evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26 yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (Nparticipants=3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Language: Английский

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Associations Among EEG Aperiodic Slope, Infant Temperament, and Maternal Anxiety/Depression Symptoms in Infancy

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(1)

Published: Jan. 1, 2025

The aperiodic "slope" of the EEG power spectrum (i.e., exponent, commonly represented as a slope in log-log space) is hypothesized to index cortical excitatory-inhibitory balance. Slope has been associated with various neurodevelopmental outcomes older children and adults, well family history ADHD infants. Here, we investigate associations among slope, temperament, maternal internalizing (anxiety depression) symptoms large cohort typically developing A steeper was higher scores on temperament domains orienting/regulation surgency but not negative affectivity. Maternal did appear be directly moderated association between temperament. Specifically, stronger infant orienting/regulation. These results demonstrate behavior early infancy, which may reflect differences development global inhibitory networks. Longitudinal research childhood necessary better understand nature these relations during their potential impact later socioemotional outcomes.

Language: Английский

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Gestational Duration and Postnatal Age‐Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG)

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(1)

Published: Jan. 1, 2025

ABSTRACT The brain develops most rapidly during pregnancy and early neonatal months. While prior electrophysiological studies have shown that aperiodic activity undergoes changes across infancy to adulthood, the role of gestational duration in periodic remains unknown. In this study, we aimed bridge gap by examining associations between EEG power spectrum both neonates toddlers. This cross‐sectional study involved data from 73 (postnatal age 1–5 days, 40 females) 56 toddlers 2.9–3.2 years, 28 FinnBrain Birth Cohort Study. spectra were parameterized components using SpecParam tool. We tested as well postnatal parameters while including birth weight child sex covariates. For neonates, multilevel models employed, considering different acquisitions (sleep auditory paradigm + sleep), toddlers, regression used only was available. found longer associated with a steeper frequencies Effect especially strong ( β = 0.45, p 0.004), it remained nearly statistically significant 0.061). quadratic association beta center frequency (12.5–30 Hz) found. overall higher females compared males. Offset (calculated curve at 2.5 theta had negative but not Our results suggest may relatively long‐lasting effects on physiology. possible behavioral cognitive consequences these are enticing topics for future research.

Language: Английский

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Oscillatory But Not Aperiodic Frontal Brain Activity Predicts the Development of Executive Control From Infancy to Toddlerhood

Developmental Science, Journal Year: 2025, Volume and Issue: 28(2)

Published: Feb. 9, 2025

Executive control (EC) emerges in the first year of life, with ability to inhibit prepotent responses (inhibitory [IC]) and flexibly readapt (cognitive flexibility [CF]) steadily improving. Simultaneously, electrophysiological brain activity undergoes profound reconfiguration, which has been linked individual variability EC. However, most studies exploring this relationship have used relative/absolute power tasks that combine different executive processes. In addition, conflates aperiodic oscillatory activity, hinders interpretation between cognition. current study, we Early Childhood Inhibitory Touchscreen Task (ECITT) examine development EC skills from 9 16 months a longitudinal sample, related performance task resting-state EEG (rs-EEG) power, separating activity. Our results showed improvement IC but not CF age. alpha theta were concurrent (9-mo.) predictors toddlerhood, whereas exponent signal did contribute These findings demonstrate relevance for cognitive provide an early marker

Language: Английский

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Measuring and interpreting individual differences in fetal, infant, and toddler neurodevelopment

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101539 - 101539

Published: March 1, 2025

As scientists interested in fetal, infant, and toddler (FIT) neurodevelopment, our research questions often focus on how individual children differ their neurodevelopment the predictive value of those differences for long-term neural behavioral outcomes. Measuring interpreting can present challenges: Is there a "standard" way human brain to develop? How do semantic, practical, or theoretical constraints that we place studying "development" influence measure interpret differences? While it is important consider these across lifespan, they are particularly relevant conducting due rapid, profound, heterogeneous changes happening during this period, which may be This article, therefore, has three goals: 1) provide an overview about studied field developmental cognitive neuroscience, 2) identify challenges considerations when 3) discuss potential implications solutions moving forward.

Language: Английский

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Resting Electroencephalography Microstates and Alpha Power Modulation in Preschool-Aged Children with Autism Spectrum Disorder

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 544 - 544

Published: May 22, 2025

Background/Objectives: Emerging evidence suggests that individuals with autism spectrum disorder (ASD) exhibit altered neural connectivity and disrupted brain network dynamics, which can be captured through EEG microstate analysis. Most research to date has focused on older children, adolescents, or adults ASD, while studies focusing preschool-aged children ASD remain limited. Given early development is critical for understanding the onset progression of more targeting this age group essential. Methods: In study, resting data were collected from 59 typically developing (TD) participants. Results: The results revealed a reduction in global explained variance coverage indicating poorer social performance was independent alpha power after removal 1/f-like aperiodic signal. These findings reflect symptoms commonly observed ASD. Additionally, found modulate occurrence duration microstates both groups. Conclusions: Our highlight atypical serve as reliable biomarkers offering valuable insights into neurophysiological mechanisms underlying paving way future directions.

Language: Английский

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Developing the attentive brain. Contribution of cognitive neuroscience to a theory of attentional development

Human Development, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Sept. 3, 2024

Attention is a fundamental cognitive mechanism whose primary function to regulate and organize the flow of perceptions actions shaping our mental life. Early models have highlighted aspects sustained, selective, executive control as essential components attention. These three broad can be further subdivided into subordinate operations, depending on whether particular mostly driven by external stimulation (bottom-up attention) or relies endogenous processes such voluntary intentions expectations (top-down attention). After several decades neuroscience research, these different functions been associated with specific circuits brain regions. Based framework, this paper presents theory attention development discusses behavioral evidence regarding during first years

Language: Английский

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Aperiodic and Hurst EEG exponents across early human brain development: a systematic review

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Abstract In electroencephalographic (EEG) data, power-frequency slope exponents (1/ f β ) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/ evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (N participants =3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Language: Английский

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Developmental trajectories of EEG aperiodic and periodic components: Implications for understanding thalamocortical development during infancy

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 25, 2023

Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding early circuit in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive distinct milestones maturation. Consistent with the transient developmental progression thalamocortical circuitry, we observe presence then absence alpha high beta peaks across three-year period, as well emergence a low peak (12-20Hz) after six months age. We present preliminary evidence that is associated higher thalamocortical-dependent, anesthesia-induced coherence. Together, these findings suggest may reflect state network development.

Language: Английский

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