Frontiers in Marine Science,
Journal Year:
2022,
Volume and Issue:
9
Published: Sept. 23, 2022
Immunostimulants
are
becoming
one
of
the
most
effective
models
for
healthy
and
sustainable
development
against
vibriosis,
which
is
a
serious
threat
to
global
aquaculture
industry.
This
study
evaluated
effects
different
concentrations
Ganoderma
lucidum
polysaccharides
(GLPs)
on
immunomodulation
disease
resistance
pearl
gentian
groupers.
The
relative
percent
survival
groupers
challenged
with
Vibrio
harveyi
ZJ0603
by
intraperitoneal
injection
reached
53.3,
60,
70,
73.3%
in
GLPs2,
GLPs4,
GLPs6,
GLPs8
groups,
respectively,
significantly
higher
than
that
33.3%
control
group.
Meanwhile,
expression
levels
immune-relative
genes,
including
IgM
,
MHC-Iα
MHC2
IL-1β
TNF-α
were
upregulated
liver,
spleen,
head
kidney,
thymus
within
28
days
after
GLP
injection.
total
serum
protein
activities
catalase,
superoxide
dismutase,
lysozymes
all
groups
compared
those
control.
Moreover,
optimal
immunity
effect
was
observed
an
GLPs
at
6
or
8
mg/ml.
results
demonstrate
immunostimulant,
enhancing
both
specific
non-specific
as
well
grouper.
Annals of Animal Science,
Journal Year:
2023,
Volume and Issue:
23(4), P. 951 - 969
Published: Feb. 7, 2023
Abstract
Aquaculture
is
one
of
the
primary
food-producing
sectors
in
world
that
ensures
human
nourishment.
However,
aqua
farmers
are
facing
serious
problems
due
to
disease
outbreaks
and
development
antimicrobial
resistance.
Until
now,
chemical
or
antibiotic
based
strategies
have
been
applied
control
related
concern
aquaculture.
Frequent
usage
antibiotics
feed
disinfectant
overcome
may
end
up
with
negative
impacts
environment
human.
Utilization
plant
derived
polysaccharides
has
drastically
increased
their
effective
roles
could
serve
as
a
best
replacement
for
agents
antibiotics.
In
addition,
compounds
extracts
were
utilized
improve
immunity,
intestinal
health
growth
performance
aquaculturable
organisms.
large
number
plant-based
was
immunostimulants
Hence,
this
review
aims
highlight
multifunctional
properties
Moreover,
advantages
different
concentration
additive
aquaculture
sector
discussed
herein.
Aquaculture International,
Journal Year:
2024,
Volume and Issue:
32(6), P. 7929 - 7951
Published: May 22, 2024
Abstract
This
study
aimed
to
assess
the
effects
of
dietary
Cyanus
depressus
(CD)
extract
on
rainbow
trout
(
Oncorhynchus
mykiss
)
physiology
and
health.
Fish
with
an
average
weight
3.29
±
0.34
g
were
allocated
four
feeding
groups,
receiving
diets
containing
CD
at
doses
0
(Control),
0.5
(CD05),
1
(CD1),
2
(CD2)
kg
−1
for
a
period
60
days.
Results
revealed
significant
improvements
in
final
body
weight,
gain,
specific
growth
rate
groups
supplemented
g/kg
extract.
Lipase
activity
increased
notably
fish
fed
CD0.5,
CD1,
CD2
diets.
The
CD1
group
exhibited
highest
trypsin
activity,
while
displayed
amylase
activity.
Analysis
gene
expression
levels
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx)
showed
marked
increases
across
all
compared
control,
most
enhancement
observed
Significant
variations
immunity-related
genes
among
treatments,
tumor
necrosis
factor-alpha
(TNF-α)
interleukin-1
beta
(IL-1β)
found
diet
enriched
immune-related
was
more
prominent
than
control
group.
Notably,
extract,
heat
shock
protein
70
(HSP70)
group,
decreased
CD05
remained
statistically
unchanged
control.
Additionally,
supplementation
altered
composition
abundance
intestinal
microbiota
trout.
In
conclusion,
our
suggests
that
has
potential
enhancing
various
physiological
health
aspects
trout,
particularly
when
g/kg.
Frontiers in Veterinary Science,
Journal Year:
2025,
Volume and Issue:
12
Published: March 21, 2025
Introduction
Mushrooms
are
rich
in
protein,
polysaccharides,
and
other
nutrients
as
a
natural
homology
of
medicine
food
species,
among
which
Agaricus
bisporus
is
one
the
most
widely
cultivated
consumed
mushrooms
worldwide.
The
mushroom
stipe
by-product
industry
that
can
be
utilized
feed
resource
based
on
its
nutritional
value.
This
study
examined
effects
(ABS)
additive
growth
performance,
blood
indexes,
rumen
fermentation
parameters,
nutrient
digestion
utilization,
microbiota
heifers.
Methods
Twenty
Holstein
heifers
(268
±
9.43
d
age)
were
blocked
10
groups
2
according
to
their
live
weights
ages,
within
each
group,
randomly
allocated
1
treatments:
control
diet
(CON),
plus
ABS
(ABS,
150
g·DM/animal/d).
Results
Heifers
supplemented
with
had
higher
average
daily
gain
tendency
decrease
conversion
ratio,
but
parameters
similar
between
two
treatments.
increased
IgG,
IgA,
IgM,
SOD,
T-AOC,
GSH-Px
concentrations
while
decreasing
MDA
concentration
than
CON.
Although
energy
nitrogen
utilization
treatments,
apparent
total-tract
digestibilities
NDF
ADF
for
CON
Feeding
relative
abundance
phylum
(Verrucomicrobiota),
genera
(
Akkermansia
Ligilactobacillus
),
species
muciniphila
murinus
)
Discussion
In
conclusion,
receiving
have
greater
improved
serum
immune
antioxidant
some
bacteria,
BMC Biotechnology,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 28, 2025
In
this
study,
the
biological
activities
of
Otidea
onotica
were
investigated
using
two
optimization
methods,
Response
Surface
Methodology
(RSM)
and
Artificial
Neural
Network-Genetic
Algorithm
(ANN-GA).
The
extracts
tested
for
phenolic
content,
antioxidant
potential,
acetylcholinesterase
butyrylcholinesterase
inhibitory
antiproliferative
effects
against
A549
lung
cancer
cell
line.
results
show
that
obtained
by
ANN-GA
exhibited
higher
activity
compared
to
RSM
had
total
status
(TAS),
DPPH
FRAP
values.
Phenolic
content
analysis
revealed
eight
compounds
with
highest
concentrations
caffeic
acid
(in
extract)
gallic
extract),
respectively.
Both
showed
strong
cytotoxic
cells
depending
on
concentration,
extract
showing
activity.
Our
study
provides
important
findings
therapeutic
potential
O.
particularly
reveals
method
plays
an
role
in
increasing
can
be
used
treatment
neurodegenerative
diseases
future
techniques
offer
effective
strategy
enriching
contents.
Fishes,
Journal Year:
2025,
Volume and Issue:
10(4), P. 180 - 180
Published: April 16, 2025
Replacing
fishmeal
(FM)
with
plant-based
protein
sources
remains
a
significant
challenge,
particularly
for
carnivorous
fish.
This
study
investigates
the
effect
of
dietary
Lentinus
edodes
fermentation
(LEF)
supplementation
on
Japanese
eel
(Anguilla
japonica)
fed
fermented
soybean
meal
(FSM)
as
partial
FM
replacement.
The
positive
control
consisted
64%
(Con),
and
negative
(FSM
group)
included
52%
plus
12%
FSM.
Two
experimental
diets
were
formulated
by
adding
2%
LEF
(LEF2
3%
(LEF3
to
diet.
diet
was
administered
eels
weighing
62.50
±
2.14
g
12
weeks.
fish
randomly
assigned
four
groups,
three
replicates
100
per
group.
results
indicated
that
growth
performance
feed
efficiency
significantly
reduced
in
FSM
group,
but
improved
(p
<
0.05).
did
not
affect
muscle
crude
fat
content
compared
group
>
0.05),
increased
amino
acid
levels
certain
fatty
acids
(linoleic
acid,
γ-linolenic
eicosatrienoic
DHA)
serum
TC
LDL-C
levels,
HDL-C
CAT
T-SOD
activities,
MDA
both
liver
ALT
AST
activities
elevated
accompanied
histological
abnormalities,
which
supplementation.
thickness
muscularis,
villus
height,
goblet
cell
count
intestine
Compared
control,
upregulated
spleen
tnf-α
gene
expression
downregulated
anti-inflammatory
factors
(ifn-α,
ifn-γ,
socs1,
mavs).
ameliorated
immunocompetence
induced
replacement
enhancing
immune-related
genes
(irak4,
ifn-α,
irf3,
irf11,
mavs,
traf3)
spleen.
These
suggest
beneficial
effects
may
be
attributed
its
improvement
damage
intestinal
histology,
well
enhancement
antioxidant
capacity
immunity.
Foods,
Journal Year:
2023,
Volume and Issue:
12(4), P. 859 - 859
Published: Feb. 17, 2023
polysaccharide
(ABP)
is
an
important
active
component
in
edible
mushrooms,
but
its
interaction
with
gut
microbiota
unclear.
Therefore,
this
study
evaluated
the
effect
of
ABP
on
composition
and
metabolites
human
by
