Development and validation of a nomogram for predicting cough variant asthma diagnosis

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

Abstract Background Cough variant asthma (CVA) is a specific type of characterized by chronic cough as the sole or predominant symptom. Accurate diagnosis crucial for effective treatment, yet bronchial provocation test not always feasible in clinical settings. To identify independent predictors CVA diagnosis, we developed nomogram predicting CVA. Univariate and multivariate logistic regression analyses were employed to construct model, accuracy consistency prediction model subsequently validated. Methods We conducted retrospective review data from 241 outpatients with (≥ 8 weeks) who underwent at our hospital between January 2018 December 2021. Patients categorized into group Non-CVA based on diagnostic criteria. analysis (chi-square t-tests) was performed, followed predictors. A constructed using these validated Bootstrap resampling (B = 200) calculate C-index. Additionally, receiver operating characteristic (ROC) curve decision (DCA) assess model's accuracy. Results Of outpatients, 156 (64.7%) diagnosed Multivariate identified several CVA, including triggered cold air (OR 12.493, P 0.019), exposure pungent odors 3.969, 0.002), phasing 4.515, < 0.001), history allergic rhinitis 3.231, 0.018), percentage predicted value maximum mid-expiratory flow (MMEF%pred) 0.981, 0.039) The demonstrated good discrimination (AUC 0.829) calibration, sensitivity 75.3% specificity 77.6% optimal cutoff. C-index 0.920, indicating excellent performance. Conclusions successfully user-friendly that accurately characteristics pulmonary function test. This could assist clinicians diagnosing especially patients without contraindications

Language: Английский

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Endobronchial Hamartomas as a rare cause of Chronic Cough

Respiratory Medicine Case Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102210 - 102210

Published: April 1, 2025

Language: Английский

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Non-pharmacological approaches to chronic cough

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 13(3), P. 480 - 488

Published: Dec. 17, 2024

Language: Английский

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Current opinion in refractory and/or unexplained chronic cough

Current Opinion in Otolaryngology & Head & Neck Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Purpose of review Otolaryngologists are vital to successfully managing chronic cough in adults. This presents updates regarding rapidly evolving concepts cough. Recent findings Significant growth is occurring research, strengthening the evidence its major psychosocial impacts. Elucidation neural underpinnings normal and abnormal within both peripheral central nervous systems highlight previously underappreciated complexity clinical practice recommendations emphasize personalized treatment approaches through addressing treatable traits Investigations ongoing better distinguish subgroups, multiple types important outcome measures being characterized. Newer research about encompasses pharmacologic nonpharmacologic interventions, including oral inhaled medications, superior laryngeal nerve blocks, behavioral therapy. Summary As knowledge adults continues expand practice, otolaryngologists can continue raise awareness role larynx promote multidisciplinary collaborations. In coming years, more options will likely emerge for

Language: Английский

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