International Journal of Pediatrics and Child Health, Journal Year: 2025, Volume and Issue: 13, P. 1 - 10
Published: March 18, 2025
MicroRNAs are short, highly conserved, non-coding ribonucleic acids that play an important role in the complex network of gene regulation, especially silencing. regulate expression specifically at post-transcriptional level. have a size 21 to 23 nucleotides, but there can be even few hundred. In recent years, knowledge about microRNAs has steadily grown. The miR Base database shown increase over 4000 sequences within years and, each miRNA potential target large number genes. Why new miRNAs is rising, not completely understood date. Working with forefront biomedical research. Since their discovery 1993, significant been gathered: biogenesis elucidated, components involved RNA interference identified, and insight into therapeutic importance gained - both as drugs targets for therapies. Further intensive research will help identify key molecular players this miRNA-mediated signaling pathway understand function. Strategies being developed influence activity these proteins, order draw conclusions from experiments respective functions. This certainly develop approaches treatment human diseases attributed dysfunctions. exact biological functions most still unknown. According computer-based predictions, approximately 20-30% genes genome could regulated by microRNAs. It assumed several thousand different encoded. Micro-RNA`s pathogenesis many pediatric diseases, which analyzed review detail.
Language: Английский