Oral Melanoma in Older Adults: Epidemiology, Molecular Landscape, and Treatment Strategies DOI
José Alcides Almeida de Arruda, Victor Zanetti Drumond, Jefferson da Rocha Tenório

et al.

Pigment Cell & Melanoma Research, Journal Year: 2025, Volume and Issue: 38(3)

Published: April 14, 2025

ABSTRACT Oral melanoma is an aggressive neoplasm arising from melanocytes in the mucosal epithelium, accounting for 0.2%–0.8% of all melanomas. Unlike cutaneous melanoma, it not associated with UV exposure, and its pathogenesis involves complex genetic molecular alterations. This predominantly affects older adults (≥ 60 years). Clinically, lesions often present as macular or nodular exophytic growth pattern, sometimes ulcerated, exhibit varied pigmentation. Diagnosis further complicated by non‐pigmented (amelanotic) variants that can resemble other oral pigmentations. Wide surgical excision remains mainstay treatment, combined chemotherapy; however, recurrence distant metastasis remain high. While immunotherapy has shown promise subtypes, efficacy uncertain. Treatment particularly challenging due to comorbidities treatment‐related morbidity. review summarizes epidemiology, clinical features, current treatment strategies adults. Key advances mechanisms underlying this are also outlined. As a strategic approach, integrating screening into routine geriatric dental care, supported diagnostic algorithms, may improve early detection, prognosis, survival outcomes vulnerable population.

Language: Английский

Oral and cutaneous immune‐related adverse events in cancer patients: Prevalence and overall survival DOI
Osias Vieira de Oliveira Filho,

Ivana Lameiras Gibbons,

Yuri de Lima Medeiros

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

To assess the prevalence of cutaneous and oral immune-related adverse events (irAEs) in cancer patients, risk factors for its development, overall survival (OS).

Language: Английский

Citations

5
Oral Melanoma in Older Adults: Epidemiology, Molecular Landscape, and Treatment Strategies DOI
José Alcides Almeida de Arruda, Victor Zanetti Drumond, Jefferson da Rocha Tenório

et al.

Pigment Cell & Melanoma Research, Journal Year: 2025, Volume and Issue: 38(3)

Published: April 14, 2025

ABSTRACT Oral melanoma is an aggressive neoplasm arising from melanocytes in the mucosal epithelium, accounting for 0.2%–0.8% of all melanomas. Unlike cutaneous melanoma, it not associated with UV exposure, and its pathogenesis involves complex genetic molecular alterations. This predominantly affects older adults (≥ 60 years). Clinically, lesions often present as macular or nodular exophytic growth pattern, sometimes ulcerated, exhibit varied pigmentation. Diagnosis further complicated by non‐pigmented (amelanotic) variants that can resemble other oral pigmentations. Wide surgical excision remains mainstay treatment, combined chemotherapy; however, recurrence distant metastasis remain high. While immunotherapy has shown promise subtypes, efficacy uncertain. Treatment particularly challenging due to comorbidities treatment‐related morbidity. review summarizes epidemiology, clinical features, current treatment strategies adults. Key advances mechanisms underlying this are also outlined. As a strategic approach, integrating screening into routine geriatric dental care, supported diagnostic algorithms, may improve early detection, prognosis, survival outcomes vulnerable population.

Language: Английский

Citations

0