Vigorous exercise associates with the abundance of gut bacterial species reflecting energy pathways: an epidemiological cross-sectional analysis within the Lifelines Dutch Microbiome Project DOI Creative Commons
Jordi Morwani‐Mangnani, Quinten R. Ducarmon, Georg Zeller

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

ABSTRACT Background Regular physical activity (PA) is vital for proper organ functions including the gut. Despite existing research, it remains unclear how gut microbiome affected by different intensities of PA, and other lifestyle factors influence this relationship. Here we study relation between PA intensity composition function in a large Lifelines Dutch Microbiome Project dataset. Methods A cross-sectional design was performed on 5409 adults aged 40 to 60 from community-based all these participants metagenomic shotgun data available. Participants were categorized into sedentary (N=2501), moderate (N=1915), vigorous (N=993) groups, based self-reported levels. We investigated association microbial diversity, bacterial species, metabolic pathways multiple regression models sequentially adjusted covariates age/sex, BMI, stool consistency diet quality/alcohol intake. Results Vigorous but not significantly associated with higher alpha diversity (i.e., species richness, Shannon Simpson diversity) as compared PA. Compared group, group showed lower abundance Lawsonibacter asaccharolyticus (β = −0.003, p 0.042), even after extensive covariate adjustments correction testing. Other initially also they disappeared adjusting resulting loss significance. Pathway analysis significant enrichment two distinct related cellular energy recycling ( Pyruvate fermentation acetate lactate II, β 8.11×10 −05 , 0.035) purine metabolism Purine ribonucleosides degradation 3.36×10 −04 0.039) engaging Conclusions specific alterations composition. The within may be linked increased permeability. identified hints at potential role affecting functionality host health. results our modeling strategy highlight importance dietary understand impact independently influences.

Language: Английский

Six months of different exercise type in sedentary primary schoolchildren: impact on physical fitness and saliva microbiota composition DOI Creative Commons
Annamaria Mancini, Daniela Vitucci, Vito Alessandro Lasorsa

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 24, 2024

Lifestyle influences microbiota composition. We previously reported a healthier composition in saliva from active schoolchildren compared to sedentary. In the present study, we evaluated effects of 6 months different exercise types on physical fitness and 8-11-years-old sedentary schoolchildren.

Language: Английский

Citations

1
Vigorous exercise associates with the abundance of gut bacterial species reflecting energy pathways: an epidemiological cross-sectional analysis within the Lifelines Dutch Microbiome Project DOI Creative Commons
Jordi Morwani‐Mangnani, Quinten R. Ducarmon, Georg Zeller

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

ABSTRACT Background Regular physical activity (PA) is vital for proper organ functions including the gut. Despite existing research, it remains unclear how gut microbiome affected by different intensities of PA, and other lifestyle factors influence this relationship. Here we study relation between PA intensity composition function in a large Lifelines Dutch Microbiome Project dataset. Methods A cross-sectional design was performed on 5409 adults aged 40 to 60 from community-based all these participants metagenomic shotgun data available. Participants were categorized into sedentary (N=2501), moderate (N=1915), vigorous (N=993) groups, based self-reported levels. We investigated association microbial diversity, bacterial species, metabolic pathways multiple regression models sequentially adjusted covariates age/sex, BMI, stool consistency diet quality/alcohol intake. Results Vigorous but not significantly associated with higher alpha diversity (i.e., species richness, Shannon Simpson diversity) as compared PA. Compared group, group showed lower abundance Lawsonibacter asaccharolyticus (β = −0.003, p 0.042), even after extensive covariate adjustments correction testing. Other initially also they disappeared adjusting resulting loss significance. Pathway analysis significant enrichment two distinct related cellular energy recycling ( Pyruvate fermentation acetate lactate II, β 8.11×10 −05 , 0.035) purine metabolism Purine ribonucleosides degradation 3.36×10 −04 0.039) engaging Conclusions specific alterations composition. The within may be linked increased permeability. identified hints at potential role affecting functionality host health. results our modeling strategy highlight importance dietary understand impact independently influences.

Language: Английский

Citations

0