Q‐Switched 785 nm laser in the treatment of labial melanotic macules DOI Creative Commons

Giustino Gallo,

Shady M. Ibrahim, Beatrice Marina Pennati

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 1, 2024

Physiological lip melanosis is a disorder with multifactorial aetiology. It varies ethnicity and typical of people darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (pigmented squamous cell carcinoma, melanoma), drug-induced, post-inflammatory hyperpigmentation (PIH), endocrine disorders, heavy metals, smoking, amalgam tattoo, Laugier-Hunziker syndrome lentiginosis syndromes (Peutz–Jegher's syndrome) are among the factors that can cause pigmentation macules pigmented benign linear increase in pigment basal layer without any melanocyte proliferation vascular component.1 Although treatment not needed, it requested by many patients, who greatly distressed this condition. For melanosis, there is, unfortunately, no effective treatment.2 Patients frequently experiment whitening creams, camouflage lipsticks tattoos getting desired outcome.3 Histological evidence darkening shows abnormal melanin granule aggregation regular number melanocytes an excess dermal melanophages.4 These good targets for Q-switched (QS) lasers because they contain which interested chromophore. This way, collateral tissue damage be reduced. has been demonstrated QS 532-nm laser works perfectly to treat hyperpigmented lips. Nevertheless, negative effects more common, last longer intense than 1064-nm laser.5 The picosecond emit pulses much shorter target's thermal relaxation time so raise peak temperature inflicting on nearby tissues. Given this, study aimed conduct preliminary assessment application 785 nm handpiece (El.En Group, Florence, Italy) hyperpigmentation, minimize blood absorption maximize melanin. A 51-year-old male patient lower subject case study. parameters were spot size 3 mm, fluence 2.8 J/cm2, frequency 2 Hz single pass modality. To get most out technology, contact sensor was included device. follow-up appointments conducted 24 h 14 days following treatment. Our findings indicate patient's mucosa very quickly almost completely recovered, when compared (see Figure 1). Additionally, given visual analogue scale (VAS) range 1 10 value he reported indicated high degree (VAS = 9) satisfaction complete disappearance hyperpigmentation. According Loh et al. (2021), may preferred wavelength treating lesions types. On other hand, 730 emitting devices preferable lightly coefficient at expected 30% higher nm.6 Furthermore, due melanin's over haemoglobin, better 1064 532 targeting or pigment.7 Indeed, we treated different unusual body district such as internal part lip. unique characteristics being component-rich area. Of course, strategies could have used target melanin, 675 532/1064 lasers, previously investigations.8 clinical presented decided conservative approach during treatment, focus component only avoid one. side registered, pain-free bearable patient. Oral healing happens way faster healing. networks related wounds oral regulate inflammatory responses epithelial differentiation.9 In summary, use our warranted improve absorption. confirmed device utilized safety record. nearly elimination ability resume normal activities soon sessions concluded contributed level technology also had benefit having long-term pain.

Language: Английский

Q‐Switched 785 nm laser in the treatment of labial melanotic macules DOI Creative Commons

Giustino Gallo,

Shady M. Ibrahim, Beatrice Marina Pennati

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 1, 2024

Physiological lip melanosis is a disorder with multifactorial aetiology. It varies ethnicity and typical of people darker skin tones. Benign conditions (ephelides, lentigines, labial melanotic macule), malignant instances (pigmented squamous cell carcinoma, melanoma), drug-induced, post-inflammatory hyperpigmentation (PIH), endocrine disorders, heavy metals, smoking, amalgam tattoo, Laugier-Hunziker syndrome lentiginosis syndromes (Peutz–Jegher's syndrome) are among the factors that can cause pigmentation macules pigmented benign linear increase in pigment basal layer without any melanocyte proliferation vascular component.1 Although treatment not needed, it requested by many patients, who greatly distressed this condition. For melanosis, there is, unfortunately, no effective treatment.2 Patients frequently experiment whitening creams, camouflage lipsticks tattoos getting desired outcome.3 Histological evidence darkening shows abnormal melanin granule aggregation regular number melanocytes an excess dermal melanophages.4 These good targets for Q-switched (QS) lasers because they contain which interested chromophore. This way, collateral tissue damage be reduced. has been demonstrated QS 532-nm laser works perfectly to treat hyperpigmented lips. Nevertheless, negative effects more common, last longer intense than 1064-nm laser.5 The picosecond emit pulses much shorter target's thermal relaxation time so raise peak temperature inflicting on nearby tissues. Given this, study aimed conduct preliminary assessment application 785 nm handpiece (El.En Group, Florence, Italy) hyperpigmentation, minimize blood absorption maximize melanin. A 51-year-old male patient lower subject case study. parameters were spot size 3 mm, fluence 2.8 J/cm2, frequency 2 Hz single pass modality. To get most out technology, contact sensor was included device. follow-up appointments conducted 24 h 14 days following treatment. Our findings indicate patient's mucosa very quickly almost completely recovered, when compared (see Figure 1). Additionally, given visual analogue scale (VAS) range 1 10 value he reported indicated high degree (VAS = 9) satisfaction complete disappearance hyperpigmentation. According Loh et al. (2021), may preferred wavelength treating lesions types. On other hand, 730 emitting devices preferable lightly coefficient at expected 30% higher nm.6 Furthermore, due melanin's over haemoglobin, better 1064 532 targeting or pigment.7 Indeed, we treated different unusual body district such as internal part lip. unique characteristics being component-rich area. Of course, strategies could have used target melanin, 675 532/1064 lasers, previously investigations.8 clinical presented decided conservative approach during treatment, focus component only avoid one. side registered, pain-free bearable patient. Oral healing happens way faster healing. networks related wounds oral regulate inflammatory responses epithelial differentiation.9 In summary, use our warranted improve absorption. confirmed device utilized safety record. nearly elimination ability resume normal activities soon sessions concluded contributed level technology also had benefit having long-term pain.

Language: Английский

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