Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study DOI
Hao Lei, Zixuan Xing, Xin Chen

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Background Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. Methods First, we conducted two‐sample Mendelian randomization based on genome‐wide association studies (GWAS) to investigate genetic causality index common diseases in dermatology. Inverse variance weighted was used estimate causality. Second, expression quantitative trait locus (eQTLs) analysis identify genes affected by Single nucleotide polymorphisms (SNPs). Third, performed function pathway enrichment, transcriptome‐wide (TWAS) eQTLs. Results It shown that rise could increase risk (IVW, beta = 0.916, OR 2.500, 95%CI:1.418‐4.408, p 0.002) through (MR), there no heterogeneity pleiotropy. There other We found 31 eQTLs strongly correlated SNPs TWAS expressions four were closely related psoriasis, including HLA‐DQA1, HLA‐DQA2, HLA‐DRB1 HLA‐DQB1. Conclusion suggested had significant positive which well documented combined genomic, transcriptome, proteome analyses.

Language: Английский

Exploration of the causality of frailty index on psoriasis: A Mendelian randomization study DOI
Hao Lei, Zixuan Xing, Xin Chen

et al.

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Background Frailty is associated with a variety of diseases, but the relationship between frailty and psoriasis remains unclear. Methods First, we conducted two‐sample Mendelian randomization based on genome‐wide association studies (GWAS) to investigate genetic causality index common diseases in dermatology. Inverse variance weighted was used estimate causality. Second, expression quantitative trait locus (eQTLs) analysis identify genes affected by Single nucleotide polymorphisms (SNPs). Third, performed function pathway enrichment, transcriptome‐wide (TWAS) eQTLs. Results It shown that rise could increase risk (IVW, beta = 0.916, OR 2.500, 95%CI:1.418‐4.408, p 0.002) through (MR), there no heterogeneity pleiotropy. There other We found 31 eQTLs strongly correlated SNPs TWAS expressions four were closely related psoriasis, including HLA‐DQA1, HLA‐DQA2, HLA‐DRB1 HLA‐DQB1. Conclusion suggested had significant positive which well documented combined genomic, transcriptome, proteome analyses.

Language: Английский

Citations

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