Effectiveness, safety, and patient satisfaction of carboxytherapy as an adjunctive treatment for periorbital hyperpigmentation

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Introduction Dark under‐eye circles or periorbital hyperpigmentation constitute a prevalent and challenging cosmetic problem with diverse etiologies types. While modifying exacerbating habits can provide partial relief for the pigmentary vascular factors associated this condition, despite abundance of available treatment options, there is currently lack gold‐standard evidence‐based treatments proposed curing disorder. Objectives This study aimed to assess safety effectiveness carboxytherapy in treating hyperpigmentation. Material Methods In 4‐week single‐arm clinical trial, 20 eligible Iranian patients symmetric received weekly intradermal carboxytherapy. The involved administering 10–20 mL CO2 at rate mL/min temperature 15°C duration ranging from few seconds 1 min. Follow‐up assessments were conducted month after final session. primary outcome was defined as changes ΔE variations pigmentation observed between orbital extra‐orbital skin before trial. Results reported satisfaction statistically significant reduction achieved through lateral ( p = 0.002), middle 0.001), medial 0.001) regions area. total response estimated 20%. Patient exceeded changes, no linear relationship 0.084). Conclusion Carboxytherapy be an effective safe

Language: Английский

---

Is there a gold standard for treating periorbital hyperpigmentation? – A narrative review of the latest evidence

Journal of Cutaneous and Aesthetic Surgery, Journal Year: 2025, Volume and Issue: 0, P. 1 - 9

Published: March 19, 2025

Background Periorbital hyperpigmentation (POH) is a common esthetic concern, characterized by light to dark brown pigmentation or violaceous discoloration of the eyelids. It multifactorial, associated with signs aging and tiredness, affects approximately 30% individuals, predominantly women aged 16–25. Objective This narrative review aims evaluate efficacy various treatments for POH, identifying potential gold standard therapies based on latest evidence from clinical trials. Methods A comprehensive search was conducted MEDLINE (PubMed) trials addressing POH treatments, excluding those focused cosmetic interventions tear through type POH. The initial yielded 654 publications, 18 studies meeting inclusion criteria, encompassing total 619 participants. Results reviewed evaluated range including platelet-rich plasma (PRP), laser therapy, carboxytherapy, chemical peels, microneedle fractional radiofrequency, autologous fat. PRP showed high patient satisfaction but less effective compared peels emulsified fat in some studies. Laser therapies, particularly Q-switched Nd carbon dioxide (CO2) lasers, demonstrated favorable outcomes, CO2 showing higher than carboxytherapy microneedling. Carboxytherapy well-tolerated potent treatments. Chemical especially involving glycolic acid, rapid significant improvement pigmentation. Microneedle radiofrequency Vitamin C mesotherapy also proved beneficial, latter achieving highest despite procedural discomfort. Conclusion No single treatment modality emerged as definitive Most effectiveness reducing fell short complete eradication. choice should be individualized, considering patient-specific factors preferences. Further comparative are needed optimize strategies

Language: Английский

---

The investigation and comparison of the efficacy and safety of stromal vascular fraction (SVF), platelet rich plasma (PRP), and 1064‐nm Q‐switched Nd:YAG laser in reducing nanofat treated infraorbital dark circles and wrinkles: A controlled blinded randomized clinical trial

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(6)

Published: June 1, 2024

Abstract Background To evaluate the efficacy and safety of stromal vascular fraction (SVF), platelet rich plasma (PRP), 1064‐nm Q‐switched Nd:YAG laser in reducing nanofat treated dark circles wrinkles under eyes. Method This study was a single‐blinded randomized clinical trial conducted on patients with suborbital darkening eyes that randomly divided into control case groups. In group, 15 were one session injection only, five each intervention groups received nanofat+SVF injection, nanofat+PRP injection+Nd:YAG laser, respectively. Assessments methods (1) evaluation degree darkness repair by blinded dermatologist based photographs, (2) investigating patient satisfaction, (3) using biometric variables for color, thickness, density skin (only 3 months after treatment), (4) recording possible adverse effects. Conclusion terms extent reduction intensity eyes, combined treatment together SVF, PRP, had much greater therapeutic effect than alone. all three treatments, 100% satisfied. variables, amount changes colorimeter, complete dermal density, between different statistically significant. The use treatments including SVF 1064 may be more effective alone, infraorbital wrinkles.

Language: Английский

---

The assessment of the impact of carboxytherapy and selected chemical peels on cosmetic defects and signs of aging of skin around eyes

Journal of Cosmetic and Laser Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Aug. 13, 2024

Objective The purpose of this study was to assess changes in skin elasticity and other defects related the aging around eyes following use combination treatment carboxytherapy chemical peels (ferulic acid combined with ascorbic acid, lactobionic acid).

Language: Английский

---

EXPERIMENTAL RESEARCH OF THE PHARMACOLOGICAL EFFECT OF CARBON DIOXIDE IN THE CORRECTION OF INFLAMMATION

ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS, Journal Year: 2024, Volume and Issue: 2, P. 48 - 53

Published: July 9, 2024

Osteoarthritis is considered one of the leading causes chronic disability and a significant problem on human health economy. Chronic pain dominant symptom that prompts patients to seek medical attention. Pain mechanisms in osteoarthritis remained unknown for long time. However, it known inflammation joint can be key factor occurrence exacerbation or changes perception pain. Pharmacological therapy often based use steroidal non-steroidal anti-inflammatory drugs, but their long-term large doses cause side effects. That why development new methods treatment inflammatory processes object active research, as they affect various mechanisms. In this context, carboxytherapy an interesting alternative addition existing regimens aimed at reducing with osteoarthritis. This method involves administration carbon dioxide (CO2) improve blood supply tissues, which contribute humoral, biochemical tissue Studying effects animal models important understanding its potential benefits action. Objective. Study properties both monotherapy combined use. Methods. Carboxytherapy injection when used combination formalin model animals. Results. The obtained research results prove inflammationin Conclusions. enhanced effect conventional drugs establishment indicates therapeutic value CO2, while emphasizing need further in-depth studies explore confirm efficacy clinical

Language: Английский

---

The Impact of Carboxytherapy and Treatments Combining Carboxytherapy and Selected Chemical Peels on Vascular and Pigmentary Components of the Dark Circles

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 1875 - 1885

Published: Aug. 1, 2024

Particular attention is given to the enhancement of melanin-related pigmentation (dark circles, photoaging) and vascular which are commonly located in tear trough. The objective study provide an evaluation impact carboxytherapy treatment regimen combining with lactobionic acid (20%, pH 2.1) or ferulic (14%, 4.0-5.0) ascorbic (12%) on skin defects eye area.

Language: Английский

---