The causal effect of atopic dermatitis on lung cancer: A Mendelian randomization study

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Background Growing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between two diseases is inconsistent and controversial. Therefore, we explored causal relationship AD different histological subtypes of LC by using Mendelian randomization (MR) method. Materials methods We conducted MR study based on summary statistics from genome‐wide association studies (GWAS) (10,788 cases 30,047 controls) (29,266 56,450 controls). Instrumental variables (IVs) were obtained after removing SNPs associated with potential confounders. employed inverse‐variance weighted (IVW), MR‐Egger, median to pool estimates, performed a comprehensive sensitivity analysis. Results The results IVW method suggested risk developing adenocarcinoma (LUAD) (OR = 0.91, 95% CI: 0.85‐0.97, P 0.007). Moreover, no was identified overall 0.96, 0.91–1.01, 0.101), squamous cell carcinoma (LUSC) 1.04, 0.96–1.036, 0.324), small (SCLC) 0.95, 0.82–1.10, 0.512). A test showed robustness our results. Conclusion present indicates LUAD in European population, which needs additional investigations identify molecular mechanisms.

Language: Английский

Causal relationship between inflammatory skin diseases and immunoglobulin A nephropathy: A Mendelian randomization and enrichment analysis study

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(8)

Published: Aug. 1, 2024

To investigate the causal relationship between inflammatory skin diseases (atopic dermatitis, and psoriasis) IgA nephropathy using Mendelian randomization enrichment analysis.

Language: Английский