Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study

Cancer, Journal Year: 2019, Volume and Issue: 126(6), P. 1183 - 1192

Published: Dec. 20, 2019

Background Little is known about longitudinal symptom burden, its consequences for well‐being, and whether lifestyle moderates the burden in older survivors. Methods The authors report on 36‐month data from survivors aged ≥60 years with newly diagnosed, nonmetastatic breast cancer noncancer controls recruited August 2010 through June 2016. Symptom was measured as sum of self‐reported symptoms/diseases follows: pain (yes or no), fatigue (on Functional Assessment Cancer Therapy [FACT]‐Fatigue scale), cognitive FACT‐Cognitive sleep problems depression Center Epidemiologic Studies Depression anxiety State‐Trait Anxiety Inventory), cardiac neuropathy no). Well‐being using FACT‐General scale, scores 0 to 100. Lifestyle included smoking, alcohol use, body mass index, physical activity, leisure activities. Mixed models assessed relations between treatment group (chemotherapy without hormone therapy, therapy only, controls) lifestyle, covariates. Separate tested effects fluctuations function. Results All groups reported high baseline symptoms, levels remained over time; differences were most notable problems, anxiety, neuropathy. adjusted score highest among chemotherapy‐exposed survivors, followed by therapy‐exposed versus ( P < .001). related physical, emotional, functional well‐being (eg, lower vs higher had 12.4‐point scores). composite not but activity significantly associated each outcome .005). Conclusions treatments are a level actionable symptoms greater loss time than comparable populations, suggesting need surveillance opportunities intervention.

Language: Английский

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Perceived Cognitive Impairment in Breast Cancer Survivors and Its Relationships with Psychological Factors

Cancers, Journal Year: 2020, Volume and Issue: 12(10), P. 3000 - 3000

Published: Oct. 16, 2020

Cognitive complaints are common adverse effects in cancer patients. Identifying subjects at risk could make it possible to limit their impact. We aimed explore the relationship between current cognitive and demographic psychological factors a group of breast survivors. Through an online survey, survivors reported using FACT-Cog questionnaire (Perceived Impairment) answered questions about demographics, lifestyle cancer-related characteristics. Anxiety, depression, fatigue post-traumatic stress symptoms were also assessed. used multivariable logistic regression models relationships social factors. Among 1393 survivors, 47.2% (n = 657) complaints. Chemotherapy (OR 2.26, 95%CI 1.67–3.05), age (OR21-44 vs. >65 0.14, 0.07–0.27), sleep difficulties (ORnever often 2.41, 1.47–3.95), frequency psychotropic treatments >1/week 1.70, 1.23–2.36), 2.05, 1.57–2.69) employment status (ORfull-time or part-time sick leave 1.64, 1.08–2.49) strongly associated with In this large study, half complaints, particularly after chemotherapy. Some should be detected early reduce persistent cancer: mainly difficulties, medications.

Language: Английский

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Cancer-related fatigue and sleep deficiency in cancer care continuum: concepts, assessment, clusters, and management

Supportive Care in Cancer, Journal Year: 2019, Volume and Issue: 27(7), P. 2747 - 2753

Published: March 22, 2019

Language: Английский

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Breast cancer patient experiences through a journey map: A qualitative study

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(9), P. e0257680 - e0257680

Published: Sept. 22, 2021

Background Breast cancer is one of the most prevalent diseases in women. Prevention and treatments have lowered mortality; nevertheless, impact diagnosis treatment continue to all aspects patients’ lives (physical, emotional, cognitive, social, spiritual). Objective This study seeks explore experiences different stages women with breast go through by means a patient journey. Methods qualitative which 21 or survivors were interviewed. Participants recruited at 9 large hospitals Spain intentional sampling methods applied. Data collected using semi-structured interview that was elaborated help medical oncologists, nurses, psycho-oncologists. processed adopting thematic analysis approach. Results The entails radical change day-to-day linger mid-term. Seven been defined correspond processes: diagnosis/unmasking stage, surgery/cleaning out, chemotherapy/loss identity, radiotherapy/transition normality, follow-up care/the “new” day-to-day, relapse/starting over, metastatic/time-limited chronic cancer. relevant each are highlighted, as various cross-sectional manifest throughout entire Conclusions Comprehending depth facilitates detection situations risk helps identify key moments when more precise information should be offered. Similarly, preparing for process they must confront sequelae would contribute decreasing their uncertainty concern, improving quality-of-life.

Language: Английский

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Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling

Cancers, Journal Year: 2021, Volume and Issue: 13(8), P. 1892 - 1892

Published: April 15, 2021

Breast cancer (BC) is the leading cause of cancer-related deaths among women worldwide. Ginsenosides exhibit anticancer activity against various cells. However, effects ginsenoside Rh1 on BC and underlying mechanisms remain unknown. Here, we investigated human MCF-7 HCC1428 cells signaling pathways. The in vitro were evaluated using sulforhodamine B (SRB), 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), clonogenic assay, propidium iodide (PI)/Hoechst staining, Western blotting, flow cytometry, immunofluorescence analysis. vivo determined a xenograft model via hematoxylin eosin immunohistochemistry staining tumor tissues. We found that exerted cytotoxicity by increasing cell apoptosis, autophagy, cycle arrest. These further enhanced phosphatidylinositol 3-kinase (PI3K) inhibitor but rescued inhibition reactive oxygen species (ROS). Moreover, ROS generation inhibited activation PI3K/Akt pathway. Consistently, treatment significantly reduced growth increased production protein expression LC3B cleaved caspase-3 decreased phosphorylation Akt retinoblastoma (Rb) Taken together, potential effect inducing arrest, autophagy ROS-mediated

Language: Английский

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Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

BMC Cancer, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 3, 2022

Cancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects a patient's life (physical, psychosocial, professional, socioeconomic). The aim this study was to assess severity cancer-related in group breast undergoing explore association between scores sociodemographic, clinical, biological, psychiatric, genetic factors.A cross-sectional pilot carried out at oncology outpatient unit Hôtel-Dieu de France University Hospital recruited 67 November 2017 June 2019 evaluate using EORTC QLQ-C30 scale (European Organization for Research Treatment Cancer Quality Life Questionnaire). Genotyping seven gene polymorphisms (COMT, DRD2, OPRM1, CLOCK, PER2, CRY2, ABCB1) performed Lightcycler® (Roche).The prevalence 46.3%. Multivariable analysis taking score as dependent variable showed that higher number cycles lower hemoglobin level were significantly associated with odds exhibiting fatigue. Moreover, having least C allele DRD2 SNP (vs. TT) 4.09 expressing compared TT patients. Finally, CLOCK tended display levels than patients.Our anemic high those carrying SNPs are greater risk Since no previous research has such results, future studies necessary confirm our findings.

Language: Английский

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Beneficial Exercises for Cancer-Related Fatigue among Women with Breast Cancer: A Systematic Review and Network Meta-Analysis

Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 151 - 151

Published: Dec. 27, 2022

Cancer-related fatigue (CRF) is the most common cause of physical powerlessness in women with breast cancer (BC). The practice continuous effective exercise beneficial respect to reducing CRF.

Language: Английский

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Relationship between self‐efficacy and physical activity among colorectal cancer patients: A cross‐sectional study

Nursing Open, Journal Year: 2023, Volume and Issue: 10(6), P. 3613 - 3621

Published: Jan. 7, 2023

Abstract Aim To investigate the current status of self‐efficacy and physical activity among Chinese colorectal cancer (CRC) patients explore relationship between them. Design A cross‐sectional study. Methods This study was conducted on 282 CRC in China. Structured questionnaires were used to collect data demographic clinical information, (Exercise Self‐Efficacy Scale [ESES]) (International Physical Activity Questionnaire‐Short Form [IPAQ‐SF]). Results The median (interquartile range) total score for with 52.78 (42.08–61.11), 1776.00 (1142.25–2812.05). Only 28.37% met guideline recommendations activity. significantly positively correlated ( r = 0.123, p 0.040). Patient or Public Contribution contributed this Hospital administrators facilitated implementation

Language: Английский

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Infrared laser moxibustion for cancer-related fatigue in breast cancer survivors: a randomized controlled trial

Breast Cancer Research, Journal Year: 2024, Volume and Issue: 26(1)

Published: May 21, 2024

Abstract Background Cancer-related fatigue (CRF) is a pervasive, persistent, and distressing symptom experienced by cancer patients, for which few treatments are available. We investigated the efficacy safety of infrared laser moxibustion (ILM) improving in breast survivors. Methods A three-arm, randomized, sham-controlled clinical trial (6-week intervention plus 12-week observational follow-up) was conducted at tertiary hospital Shanghai, China. The female survivors with moderate to severe were randomized 2:2:1 ILM ( n = 56) sham 56), Waitlist control (WLC)( 28) groups. Patients (SILM) groups received real or treatment, 2 sessions per week 6 weeks, total 12 sessions. primary outcome change Brief Fatigue Inventory (BFI) score from baseline follow-up until 18 assessed intention-to-treat population. Results Between June 2018 July 2021, 273 patients eligibility, 140 finally enrolled included analysis. Compared WLC, reduced average BFI 0.9 points (95% CI, 0.3 1.6, P .007) 6, difference between 1.1 0.4 1.8, .002) 18. SILM, treatment resulted non-significant reduction (0.4; 95% -0.2 0.9, .206) while between-group significant (0.7; 0.2 1.3, .014). No serious adverse events reported. Conclusion While found be safe significantly reduce compared its promising against needs verified future adequately powered trials. Trial registration Clinicaltrials.gov: NCT04144309. Registered 2018.

Language: Английский

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Impact of insomnia on ovarian cancer risk and survival: a Mendelian randomization study

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105175 - 105175

Published: June 1, 2024

Insomnia is the most common sleep disorder in patients with epithelial ovarian cancer (EOC). We investigated causal association between genetically predicted insomnia and EOC risk survival through a two-sample Mendelian randomization (MR) study.

Language: Английский

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