Successful Kidney Transplantation of Two Patients with Donors Positive for Severe Acute Respiratory Syndrome Coronavirus Infection DOI Open Access
Rouvick Gama, Mysore K. Phanish, Abbas Ghazanfar

et al.

OBM Transplantation, Journal Year: 2023, Volume and Issue: 07(02), P. 1 - 12

Published: May 23, 2023

Despite preventative measures, including vaccination, severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection may result in illness, particularly immunosuppressed transplant recipients. This has had a negative impact on organ donation and transplantation rates. However, the risk of transmission from SARS-CoV-2 positive donors to kidney recipients is unknown. We describe 2 cases successful donors. Case 1: 38-year old unvaccinated female, established haemodialysis for 1 year, with underlying reflux nephropathy. Donor tested polymerase chain reaction testing cycle threshold (CT) value 29 initially. Sequential demonstrated rise CT (37.8), aiding decision proceed. The recipient was high immunological received controlled category 3 after circulatory death (DCD) transplant. She immediate graft function did not develop infection. 2: 63-year diabetes mellitus hypertension. low pre-emptive transplantation. donor 41.5 subsequently negative. Decision made proceed brainstem (DBD) report donors, without infection, no seen post-operatively. Decisions were primarily clinical grounds assistance RT-PCR values, making this useful additional tool determining suitability people who are positive.

Language: Английский

EASL Clinical Practice Guidelines on liver transplantation DOI
Eléonora De Martin, Thomas Berg, Didier Samuel

et al.

Journal of Hepatology, Journal Year: 2024, Volume and Issue: 81(6), P. 1040 - 1086

Published: Oct. 31, 2024

Language: Английский

Citations

18
Heart transplantation: advances in expanding the donor pool and xenotransplantation DOI
Stephanie Jou,

Sean R. Mendez,

Jason Feinman

et al.

Nature Reviews Cardiology, Journal Year: 2023, Volume and Issue: 21(1), P. 25 - 36

Published: July 14, 2023

Language: Английский

Citations

25
Donor-derived infections in solid organ transplant recipients DOI
Maddalena Peghin, Paolo Grossi

Current Opinion in Organ Transplantation, Journal Year: 2023, Volume and Issue: 28(5), P. 384 - 390

Published: Aug. 8, 2023

The potential for transmission of donor-derived infections (DDIs) is impossible to eliminate, but a thoughtful and systematic approach donor evaluation can mitigate the risk. Prevention key issue clinicians must maintain high index suspicion remain vigilant in staying up date on emerging infections. COVID-19 Monkeypox have represented new challenge infectious disease screening recommendations been evolving, as knowledge field has grown. Additional considerations pretransplant deceased include testing neglected endemic diseases such strongyloidiasis HTLV 1/2. Molecular diagnostic tests improved awareness pathogenicity mollicutes fungi setting DDIs. aim this review provide an update most recent literature DDI with special focus these hot topics.

Language: Английский

Citations

10
Changes regarding solid organ transplantation during the COVID-19 pandemic DOI
Hayrunnisa Bekis Bozkurt, Öner Özdemır

World Journal of Transplantation, Journal Year: 2025, Volume and Issue: 15(3)

Published: April 18, 2025

Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 and emerged in Wuhan, China. It affects millions of people all over the world has deaths thousands people. Mortality rates were higher transplant recipients patients awaiting transplantation due to social psychological issues. also affected candidates who would be providers chain broken worldwide. The pandemic significantly solid organ procedures led various changes protocols practices ensure patient safety increase success. These include challenges screening protocols, prioritization cases, telemedicine virtual consultations, modified surgical procedures, immunosuppression management, updated research guidelines, post-transplantation process difficulties control side effects, procurement, education/support. requires a multidisciplinary approach, close collaboration between teams, adherence strict infection measures both healthcare providers. In this article, we compiled most important points an overview process.

Language: Английский

Citations

0
1-Year Outcomes of Lung Transplantation for Coronavirus Disease 2019–Associated End-Stage Lung Disease in the United States DOI Open Access
Kenji Okumura, Soma Jyothula, Thomas Kaleekal

et al.

Clinical Infectious Diseases, Journal Year: 2023, Volume and Issue: 76(12), P. 2140 - 2147

Published: Feb. 9, 2023

Abstract Background Lung transplantation can provide quality of life and survival benefits for patients with coronavirus disease 2019 (COVID-19)–associated end-stage lung disease. Characteristics outcomes these transplant recipients are limited to mostly single-center experiences or a short-term follow-up. Methods deceased donors adult COVID-19–associated between August-2020 June-2022 were analyzed using deidentified United Network Organ Sharing database. Post-transplant patient COVID-19 was compared non–COVID-19 recipients. Secondary length hospitalization, post-transplant complications, rates organ rejection. Results During the study period, 400 transplants COVID-associated comprised 8.7% all performed in States. In group, Hispanic males received at significantly higher rates. The group younger had greater need intensive care unit stay, mechanical ventilation, hemodialysis, extracorporeal membrane oxygenation support, receipt antibiotics pre-lung transplant. They allocation score, shorter wait-list time more double Post-transplant, cohort longer hospital stays, similar 1-year (COVID, 86.6% vs non–COVID, 86.3%). deaths 9.2% among Conclusions offers effective option carefully selected from prior COVID-19, long-term those etiology.

Language: Английский

Citations

8
Comparison of Short-Term Outcomes in Kidney Transplant Recipients from SARS-CoV-2–Infected versus Noninfected Deceased Donors DOI Open Access
Junji Yamauchi, Ambreen Azhar, Isaac E. Hall

et al.

Clinical Journal of the American Society of Nephrology, Journal Year: 2023, Volume and Issue: 18(11), P. 1466 - 1475

Published: Aug. 14, 2023

Acceptable post-transplant outcomes were reported in kidney transplant recipients from donors with coronavirus disease 2019 (COVID-19); however, there are no comparative studies well-matched controls.

Language: Английский

Citations

6
Early outcomes of lung transplantation with lung allografts from coronavirus disease 2019 (COVID-19)–positive donors DOI
Jae Hyun Jeon, Takashi Harano, Jack Rodman

et al.

Journal of Thoracic and Cardiovascular Surgery, Journal Year: 2023, Volume and Issue: 167(6), P. 1955 - 1964.e3

Published: Aug. 23, 2023

Language: Английский

Citations

5
Successful bilateral lung transplantation from a recent SARS‐CoV‐2 PCR positive donor DOI
Soma Jyothula,

Jayeshkumar Patel,

Abhay Dhand

et al.

Transplant Infectious Disease, Journal Year: 2023, Volume and Issue: 25(3)

Published: March 6, 2023

Citations

4
COVID-19 in patients with liver disease and liver transplant: clinical implications, prevention, and management DOI Creative Commons

Gabriel Perreault,

Charlotte K. Ching, Yael R. Nobel

et al.

Therapeutic Advances in Gastroenterology, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

The coronavirus disease 2019 (COVID-19) pandemic has had enormous implications for the care of patients with chronic liver (CLD), cirrhosis, and transplant (LT). Clinical outcomes COVID-19 vary in CLD cirrhosis compared to healthy controls, LT without LT. Several special considerations apply approach vaccination treatment practice transplantation also been heavily impacted by pandemic, including persistent reductions living donor increases an indication alcohol-related disease. Recent medical society guidelines strive standardize severe acute respiratory syndrome 2 testing donors recipients after recovered from infection, but certain controversies remain.

Language: Английский

Citations

4
COVID‐19 in organ donors: An organ procurement organization perspective DOI
Alyssa Mezochow, Judith A. Anesi, Sharon West

et al.

Transplant Infectious Disease, Journal Year: 2024, Volume and Issue: 26(2)

Published: Jan. 8, 2024

Abstract Background The COVID‐19 pandemic presented a significant challenge for Organ Procurement Organizations (OPOs) with the use of SARS‐CoV‐2 positive donors varying widely. This study used detailed single OPO data to determine success using donors. Methods We performed retrospective cohort including all referred Gift Life from January 1, 2021, June 30, 2023. Descriptive analyses were characterize referral and organ utilization. Results There 861 referrals 1 SARS‐Cov‐2 test: 282 ruled out telephone evaluation, 431 onsite evaluation (“evaluated nondonors”) 148 became For who had both nasopharyngeal lower respiratory testing completed, there was notable result discordance observed. Median cycle threshold (Ct) values similar between evaluated nondonors no change in median donor Ct over period. Transplanted organs COVID‐positive included 27 hearts, 88 livers, 5 pancreata, 107 kidneys; lung donation occurred. proportion significantly increased Conclusion large volume demonstrates increasing progressing time, supporting these nonlung transplantation. image

Language: Английский

Citations

1