OBM Transplantation, Journal Year: 2024, Volume and Issue: 08(02), P. 1 - 25
Published: April 28, 2024
Lung Transplant Recipients (LTR) are particularly vulnerable to severe infection, hospitalization, and death due community acquired respiratory viruses. As a result, the global SARS-Cov-2 pandemic poses higher risk this population. We aim study lung function, severity of infection mortality among LTR at single center. A retrospective chart review was performed on all University San Diego, California Medical Center between June 2020 September 2022. Spirometry 1-2 months then again 3 after infection. Patients were closely monitored for development acute cellular rejection (ACR). 72 infected with COVID-19. 37.5% required hospital admission, which 25.9% management in intensive care unit (ICU). 73.6% had received least one vaccination dose prior Post-infection, median drop FEV1 140 mL FVC 25 within months. At post-infection reduction slightly larger 75 ml, while decline decreased 55 ml. Overall, rates ACR population both 4.2%. Additionally, monoclonal antibody (mAb) therapy reduced hospitalization (20.9% vs 62%) (0% 10.3%), Our found low confirmed COVID-19, despite statistically significant FEV1, trends FVC. The use vaccinations mAb hospitalizations, reducing as well.
Language: Английский